Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Douglas C. Rouse"'
Autor:
Pratiksha I. Thakore, Jennifer B. Kwon, Christopher E. Nelson, Douglas C. Rouse, Matthew P. Gemberling, Matthew L. Oliver, Charles A. Gersbach
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Repression of gene transcription using CRISPR-Cas9 has been achieved in vitro but not for delivery into adult animal models. Here, the authors use AAV8 to deliver the transcriptional repressor dSaCas9KRAB to the cholesterol regulator Pcsk9, and show
Externí odkaz:
https://doaj.org/article/46f1559feeb54a51902bab3a11b455bc
Autor:
Gayathri R Devi, Dorababu Sannareddy, Alexandra Bennion, Ashlyn Rickard, Douglas C Rouse, Mark W Dewhirst, Gregory M Palmer
Publikováno v:
Cancer Research. 83:P3-08
Background: Lymphovascular invasion (LVI) is a major route of metastatic dissemination and recent studies indicate its value as an independent prognostic indicator for advanced breast, colorectal, squamous cell, prostate, brain cancers. LVI is a clin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c77f279e420b3817c56428a34cc04efb
https://doi.org/10.1158/1538-7445.sabcs22-p3-08-06
https://doi.org/10.1158/1538-7445.sabcs22-p3-08-06
Autor:
Ashlyn G. Rickard, Dorababu S. Sannareddy, Alexandra Bennion, Pranalee Patel, Scott J. Sauer, Douglas C. Rouse, Samantha Bouchal, Harrison Liu, Mark W. Dewhirst, Gregory M. Palmer, Gayathri R. Devi
Publikováno v:
Cancers; Volume 15; Issue 8; Pages: 2261
Inflammatory breast cancer (IBC), an understudied and lethal breast cancer, is often misdiagnosed due to its unique presentation of diffuse tumor cell clusters in the skin and dermal lymphatics. Here, we describe a window chamber technique in combina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f79d136ca831b1e97d7038bf53730ad
Autor:
Alejandro Barrera, Keith Siklenka, Erica Rodriguez, Josephine C. Bodle, Liqing Li, Mariah F. Hazlett, Matthew Gemberling, Anne E. West, Douglas C. Rouse, Isaac B. Hilton, Victoria J. Madigan, Valentina Cigliola, Heather Daniels, Charles A. Gersbach, Luke C. Bartelt, Kenneth D. Poss, Ariel Kantor, Katherine R. Tonn-Eisinger, Fang Liu, Aravind Asokan, Courtney A. Williams, Timothy E. Reddy, Maria Ciofani
Publikováno v:
Nature methods
CRISPR-Cas9 technologies have dramatically increased the ease of targeting DNA sequences in the genomes of living systems. The fusion of chromatin-modifying domains to nuclease-deactivated Cas9 (dCas9) has enabled targeted epigenome editing in both c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96f7c24610092296a88dd7c983461b7f
http://europepmc.org/articles/PMC8349887
http://europepmc.org/articles/PMC8349887
Autor:
Erica Rodriguez, Mariah F. Hazlett, Heather Daniels, Isaac B. Hilton, Anne E. West, Aravind Asokan, Courtney A. Williams, Matthew Gemberling, Charles A. Gersbach, Ariel Kantor, Kenneth D. Poss, Keith Siklenka, Valentina Cigliola, Katherine R. Tonn-Eisinger, Douglas C. Rouse, Fang Liu, Liqing Li, Josephine C. Bodle, Alejandro Barrera, Timothy E. Reddy, Luke C. Bartelt, Victoria J. Madigan, Maria Ciofani
The discovery, characterization, and adaptation of the RNA-guided clustered regularly interspersed short palindromic repeat (CRISPR)-Cas9 system has greatly increased the ease with which genome and epigenome editing can be performed. Fusion of chroma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e49ca7f1b8ea2a06b31e71baa371c63
https://doi.org/10.1101/2021.03.08.434430
https://doi.org/10.1101/2021.03.08.434430
Immediate Release of Gastrin-Releasing Peptide Mediates Delayed Radiation-Induced Pulmonary Fibrosis
Autor:
Anastasiya Birukova, Karissa Heck, Frank Cuttitta, Douglas C. Rouse, Miglena K. Komforti, Robert M. Tighe, Shutang Zhou, Kenneth Young, Jessica Vidas, Erik J. Soderblom, Mary E. Sunday, Christopher B. Toomey
Publikováno v:
Am J Pathol
Radiation–induced pulmonary fibrosis (RTPF) is a progressive, serious condition in many subjects treated for thoracic malignancies or after accidental nuclear exposure. No biomarker exists for identifying the irradiated subjects most susceptible to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d49c3a406ae84313e4eb019dec08fcd4
https://europepmc.org/articles/PMC6521890/
https://europepmc.org/articles/PMC6521890/
Autor:
Jonathan I. Epstein, Jason A. Somarelli, David M. Virshup, M. S. Marengo, Katie Ware, Douglas C. Rouse, Daneen Schaeffer, Y. Zhao, Andrew J. Armstrong, Alexander J. Hish, Tristan Bepler, Mariano A. Garcia-Blanco, Anne F. Buckley
Publikováno v:
Oncogene
The cascade that culminates in macrometastases is thought to be mediated by phenotypic plasticity, including epithelial–mesenchymal and mesenchymal–epithelial transitions (EMT and MET). Although there is substantial support for the role of EMT in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67b088c67cf2f34cd332c10afa5db301
https://doi.org/10.1038/onc.2015.497
https://doi.org/10.1038/onc.2015.497
Autor:
Christopher E. Nelson, Matthew Gemberling, Pratiksha I. Thakore, Matthew L. Oliver, Douglas C. Rouse, Charles A. Gersbach, Jennifer B. Kwon
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
CRISPR-Cas9 transcriptional repressors have emerged as robust tools for disrupting gene regulation in vitro but have not yet been adapted for systemic delivery in adult animal models. Here we describe a Staphylococcus aureus Cas9-based repressor (dSa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cc93d4c2a50aae9113b230c908316f6
http://europepmc.org/articles/PMC5920046
http://europepmc.org/articles/PMC5920046
Autor:
Ruwan Gunaratne, David S. Pisetsky, Douglas C. Rouse, Jaewoo Lee, Angelo Moreno, Silvia Gabriela Herrera, Rebekah R. White, Jessica McDade, Rachel E. Rempel, Ibtehaj A. Naqvi, Bruce A. Sullenger
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy, vol 26, iss 4
Nucleic acid binding polymers (NABPs) have been extensively used as vehicles for DNA and RNA delivery. More recently, we discovered that a subset of these NABPs can also serve as anti-inflammatoryagents by capturing pro-inflammatory extracellular nuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85dfe6c773be5d6d7698fc38bd7576c7
https://europepmc.org/articles/PMC6079560/
https://europepmc.org/articles/PMC6079560/
Autor:
Tal Burt, Huali Wu, Robert J. Noveck, Douglas C. Rouse, Kihak Lee, Thomas C. Hawk, Shein-Chung Chow, Anita T. Layton, Bennett B. Chin, Douglas H. Weitzel, Michael Cohen-Wolkowiez
Publikováno v:
Journal of Nuclear Medicine. 56:1793-1799
Intraarterial microdosing (IAM) is a novel drug development approach combining intraarterial drug delivery and microdosing. We aimed to demonstrate that IAM leads to target exposure similar to that of systemic full-dose administration but with minima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63637a59f7c288142edf81a5693d97fb
https://doi.org/10.2967/jnumed.115.160986
https://doi.org/10.2967/jnumed.115.160986