Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Douglas C. Hanson"'
Autor:
Douglas C. Hanson, Antoni Ribas, Robert Millham, Paul C. Canniff, Dennis Noe, Steven H. Bernstein, Jesus Gomez-Navarro, Deborah Jean Guyot, Amarnath Sharma
Publikováno v:
The Oncologist. 12:873-883
Tremelimumab (CP-675,206) is a fully human monoclonal antibody specific for human cytotoxic T lymphocyte-associated antigen 4 (CTLA-4, CD152) in clinical development for patients with cancer. Blocking the CTLA-4 negative costimulatory receptor with t
Autor:
John Charles Kath, Kimberly A. Verdries, Kevin Koch, Stephan Grissmer, Angela Nguyen, Paul C. Canniff, Ann C. Cunningham, Robert J. Mather, Matthew J. Bruns, Douglas C. Hanson, E. Edward Mena, K. George Chandy, Michael D. Cahalan, Carol B. Donovan, Heiko Rauer, Burgess Laurence E, George A. Gutman, James P. Rizzi
Publikováno v:
British Journal of Pharmacology. 126:1707-1716
UK-78,282, a novel piperidine blocker of the T lymphocyte voltage-gated K+ channel, Kv1.3, was discovered by screening a large compound file using a high-throughput 86Rb efflux assay. This compound blocks Kv1.3 with a IC50 of ∼200 nM and 1 : 1 stoi
Autor:
M. Ramchandani, Carol B. Donovan, Burgess Laurence E, Robert J. Mather, Kevin Koch, Kelvin Cooper, Matthew J. Bruns, M. S. Biggers, Eric J. Gilbert, Douglas C. Hanson, Jacqueline H. Smitrovich
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:1047-1052
UK-78,282 was identified in a human T cell 86Rb efflux high-throughput screen of our compound libraries. This compound was found to be a potent and selective blocker of human T cell voltage-gated K+ channels and to inhibit T cell activation. The SAR
Autor:
James E. Hall, George A. Gutman, Chao-lin Lee, Jayashree Aiyar, James G. Boyd, James P. Rizzi, Douglas C. Hanson, Jane M. Withka, Wen Lin, David H. Singleton, K. George Chandy, Mariella Simon, Brent A. Dethlefs, Glenn C. Andrews
Publikováno v:
Neuron. 15(5):1169-1181
The architecture of the pore-region of a voltage-gated K+ channel, Kv1.3, was probed using four high affinity scorpion toxins as molecular calipers. We established the structural relatedness of these toxins by solving the structures of kaliotoxin and
Publikováno v:
Cytokine. 3:277-283
Tenidap is a new antiarthritic drug of novel chemical structure. This study shows the effects of tenidap on the in vitro synthesis of interleukin 1 (IL-1). IL-1 production by murine peritoneal macrophages was induced either by stimulation with lipopo
Autor:
Rachel Luu, Alain Vicari, Ningli Zhang, Shawn R. Makinen, Risini D. Weeratna, Douglas C. Hanson, Shobhna Patel, Arthur M. Krieg
Publikováno v:
Cancer immunology, immunotherapy : CII. 58(4)
The anti-tumor properties of Toll-like receptor (TLR) 9 agonist CpG oligodeoxynucleotides (ODN) are enhanced by combinations with several cytotoxic chemotherapy regimens. The mechanisms of this added benefit, however, remain unclear. We now report th
Publikováno v:
Clinical Immunology and Immunopathology. 57:45-63
Recently, IL-1 inhibitors from urine, monocytes, or monocyte lines have been described. The relationship of these inhibitors to the production, release, and immunological effects of IL-1 is unclear. The present studies were initiated to describe and
Autor:
Kevin Koch, Douglas C. Hanson
Publikováno v:
Inflammation Research. 45:435-437
Publikováno v:
Annual Reports in Medicinal Chemistry ISBN: 9780120405329
Publisher Summary Advances in molecular biology and patch-clamp technology reflect in the discovery of type- n voltage gated potassium channel (Kv1.3) in T lymphocytes. Small-molecule blockers of Kv1.3 inhibit mitogen-induced activation of T cells. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f3661255993a13ebb6961e64664d335
https://doi.org/10.1016/s0065-7743(08)61476-1
https://doi.org/10.1016/s0065-7743(08)61476-1
Autor:
Snyder, M. Ramchandani, M. F. Newborg, M. S. Biggers, Michael LeRoy Biehl, Richard M. Shepard, Kevin Koch, Gayle K. Schulte, K. Cooper, Douglas C. Hanson
Publikováno v:
Journal of medicinal chemistry. 38(8)