Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Douglas C. Goodwin"'
Publikováno v:
Frontiers in Chemical Biology, Vol 3 (2024)
Many novel structural features impart a robust catalase activity to KatG that is absent from all other members of its superfamily. The conformationally dynamic “Arg switch” and oxidizable “proximal Trp” have both figured prominently in invest
Externí odkaz:
https://doaj.org/article/1e593594164a4a88bf9d7505e1a9a9d7
Autor:
Sara E. McCarty, Amanda Schellenberger, Douglas C. Goodwin, Ngolui Rene Fuanta, Babu L. Tekwani, Angela I. Calderón
Publikováno v:
Molecules, Vol 20, Iss 6, Pp 11459-11473 (2015)
The growing resistance to current antimalarial drugs is a major concern for global public health. The pressing need for new antimalarials has led to an increase in research focused on the Plasmodium parasites that cause human malaria. Thioredoxin red
Externí odkaz:
https://doaj.org/article/fbc2607413c24984ab173ac251b6c8a6
Autor:
Tarfi Aziz, Douglas C. Goodwin
Publikováno v:
The FASEB Journal. 36
Autor:
Catarina Frazão de Faria, Miguel Viveiros, Callie M. Barton, Jessica R. Krewall, Filomena Martins, Pedro Lopes, Miguel Machuqueiro, Susana Santos, Diana Machado, Henrique Costa, Douglas C. Goodwin, Tânia Moreira
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Biomedicine & Pharmacotherapy, Vol 144, Iss, Pp 112362-(2021)
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Biomedicine & Pharmacotherapy, Vol 144, Iss, Pp 112362-(2021)
Funding Information: We acknowledge Diogo Vila Vi?osa for valuable discussions. We acknowledge financial support from Funda??o para a Ci?ncia e a Tecnologia, Portugal through projects PTDC/MED-QUI/29036/2017, PTDC/BIA-MIC-30692/2017, UIDB/00100/2020,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93623801cb0c0b0b2b472dab02fe6177
Autor:
Tarfi Aziz, Douglas C. Goodwin
Publikováno v:
The FASEB Journal. 35
Autor:
Douglas C. Goodwin, Steven O. Mansoorabadi, Patrick H. Donnan, Patrick G. Sahrmann, Kenneth M. Merz
Publikováno v:
Journal of chemical information and modeling. 60(10)
MRP.py is a Python-based parametrization program for covalently modified amino acid residues for molecular dynamics simulations. Charge derivation is performed via an RESP charge fit, and force constants are obtained through rewriting of either prote
Publikováno v:
ACS Symposium Series ISBN: 9780841298842
ACS Symposium Series
ACS Symposium Series
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::202d75480215650ba4879f1f5c6f89f2
https://doi.org/10.1021/bk-2020-1357.ch005
https://doi.org/10.1021/bk-2020-1357.ch005
Autor:
Angela I. Calderón, Ivett Pina, Jnanendra Rath, Amir E. Wahba, Johayra Simithy, Ngolui Rene Fuanta, Jack DeRuiter, Douglas C. Goodwin, Mansour Alturki, Judith V. Hobrath, Mark T. Hamann
Publikováno v:
Biochemistry. 57:4923-4933
Tuberculosis represents a significant public health crisis. There is an urgent need for novel molecular scaffolds against this pathogen. We screened a small library of marine-derived compounds against shikimate kinase from Mycobacterium tuberculosis
Autor:
Judith V. Hobrath, Mark T. Hamann, Ngolui Rene Fuanta, Angela I. Calderón, Anna J Kochanowska-Karamyan, Johayra Simithy, Douglas C. Goodwin
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1866:731-739
Ilimaquinone (IQ), a marine sponge metabolite, has been considered as a potential therapeutic agent for various diseases due to its broad range of biological activities. We show that IQ irreversibly inactivates Mycobacterium tuberculosis shikimate ki
Autor:
Judith V. Hobrath, Madison A. Jarrard, Mansour Alturki, Thankhoe A. Rants'o, Douglas C. Goodwin, Ngolui Rene Fuanta, Angela I. Calderón
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:802-808
Single dose high-throughput screening (HTS) followed by dose-response evaluations is a common strategy for the identification of initial hits for further development. Early identification and exclusion of false positives is a cost-saving and essentia