Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Douglas C Fitzpatrick"'
Autor:
Adele Moatti, Shannon Connard, Novietta De Britto, William A. Dunn, Srishti Rastogi, Mani Rai, Lauren V. Schnabel, Frances S. Ligler, Kendall A. Hutson, Douglas C. Fitzpatrick, Alec Salt, Carlton J. Zdanski, Alon Greenbaum
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Introduction: One major obstacle in validating drugs for the treatment or prevention of hearing loss is the limited data available on the distribution and concentration of drugs in the human inner ear. Although small animal models offer some insights
Externí odkaz:
https://doaj.org/article/fcd4db90412f4a2181ab6dd7284bc67e
Autor:
Raymond A. Haggerty, Kendall A. Hutson, William J. Riggs, Kevin D. Brown, Harold C. Pillsbury, Oliver F. Adunka, Craig A. Buchman, Douglas C. Fitzpatrick
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
Cochlear synaptopathy is the loss of synapses between the inner hair cells and the auditory nerve despite survival of sensory hair cells. The findings of extensive cochlear synaptopathy in animals after moderate noise exposures challenged the long-he
Externí odkaz:
https://doaj.org/article/78ce488fd3e341f9a413b0988f936684
Autor:
Adele Moatti, Dylan Silkstone, Taylor Martin, Keith Abbey, Kendall A Hutson, Douglas C Fitzpatrick, Carlton J Zdanski, Alan G Cheng, Frances S Ligler, Alon Greenbaum
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106789- (2023)
Summary: Delivery of pharmaceutical therapeutics to the inner ear to treat and prevent hearing loss is challenging. Systemic delivery is not effective as only a small fraction of the therapeutic agent reaches the inner ear. Invasive surgeries to inje
Externí odkaz:
https://doaj.org/article/9b43e426dc0e496bb366311746e7fbe3
Autor:
William J. Riggs, Tatyana E. Fontenot, Meghan M. Hiss, Varun Varadarajan, Aaron C. Moberly, Oliver F. Adunka, Douglas C. Fitzpatrick
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
ObjectiveTo investigate the electrophysiology of the cochlear summating potential (SP) in patients with Meniere’s disease (MD). Although long considered a purely hair cell potential, recent studies show a neural contribution to the SP. Patients wit
Externí odkaz:
https://doaj.org/article/a492eab72ae74ff9a08f68a2310d5d86
Autor:
Aniket A. Saoji, Madison K. Graham, Weston J. Adkins, Kanthaiah Koka, Matthew L. Carlson, Brian A. Neff, Colin L. W. Driscoll, Douglas C. Fitzpatrick
Publikováno v:
Brain Sciences, Vol 13, Iss 2, p 330 (2023)
Intraoperative electrocochleography (ECOG) is performed using a single low-frequency acoustic stimulus (e.g., 500 Hz) to monitor cochlear microphonics (CM) during cochlear implant (CI) electrode insertion. A decrease in CM amplitude is commonly assoc
Externí odkaz:
https://doaj.org/article/93cbbcba754f43988c8867e954eac01f
Autor:
Amit Walia, Matthew A. Shew, David S. Lee, Shannon M. Lefler, Dorina Kallogjeri, Cameron C. Wick, Nedim Durakovic, Douglas C. Fitzpatrick, Amanda J. Ortmann, Jacques A. Herzog, Craig A. Buchman
Publikováno v:
Otologyneurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. 43(8)
1) To determine the relationship of electrocochleography (ECochG) responses measured on the promontory with responses measured at the round window (RW) and various intracochlear sites. 2) To evaluate if promontory ECochG responses correlate with post
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbe8bb139f2e877ad7649c72657accab
https://pubmed.ncbi.nlm.nih.gov/35861658
https://pubmed.ncbi.nlm.nih.gov/35861658
Publikováno v:
Otology & Neurotology. 43:781-788
Characterize the contribution of the auditory nerve neurophonic (ANN) to electrocochleography (ECochG) of pediatric cochlear implant (CI) recipients with and without auditory nerve spectrum disorder (ANSD).ECochG is an emerging technique for predicti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cfd254029cc925db17bdddedaf541d3
https://doi.org/10.1097/mao.0000000000003568
https://doi.org/10.1097/mao.0000000000003568
Autor:
Thomas Lenarz, Marlan R. Hansen, Robert F. Labadie, William J. Riggs, Carla V. Valenzuela, Andreas Buechner, Brendan P. O’Connell, Douglas C. Fitzpatrick, Michael S. Harris, Oliver F. Adunka, Bruce J. Gantz, Craig A. Buchman, Kanthaiah Koka, Viral D. Tejani
Publikováno v:
Otol Neurotol
OBJECTIVES. To compare intraoperative intracochlear electrocochleography (ECochG) with hearing preservation outcomes in cochlear implant (CI) subjects. DESIGN. Intraoperative electrocochleography was performed in adult CI subjects who were recipients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de5a56ee7cc27ced8541996213347a4d
https://doi.org/10.1097/mao.0000000000003403
https://doi.org/10.1097/mao.0000000000003403
Publikováno v:
Frontiers in Neuroscience, Vol 11 (2017)
Electrocochleography (ECochG) is a potential clinically valuable technique for predicting speech perception outcomes in cochlear implant (CI) recipients, among other uses. Current analysis is limited by an inability to quantify hair cell and neural c
Externí odkaz:
https://doaj.org/article/a0868f4d88d54e3984ab7219e81a2764
Autor:
William J. Riggs, Joseph P. Roche, Christopher K. Giardina, Michael S. Harris, Zachary J. Bastian, Tatyana E. Fontenot, Craig A. Buchman, Kevin D. Brown, Oliver F. Adunka, Douglas C. Fitzpatrick
Publikováno v:
Frontiers in Neuroscience, Vol 11 (2017)
Auditory neuropathy spectrum disorder (ANSD) is characterized by an apparent discrepancy between measures of cochlear and neural function based on auditory brainstem response (ABR) testing. Clinical indicators of ANSD are a present cochlear microphon
Externí odkaz:
https://doaj.org/article/c4de1349c0ad49f7a4daa66325b0cd4b