Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Douglas C Bittel"'
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0226035 (2019)
Understanding the regulation of development can help elucidate the pathogenesis behind many developmental defects found in humans and other vertebrates. Evidence has shown that alternative splicing of messenger RNA (mRNA) plays a role in developmenta
Externí odkaz:
https://doaj.org/article/8b7c4870a04e4e97b447d3840b135da1
Autor:
Douglas C Bittel, Xin-Gang Zhou, Nataliya Kibiryeva, Stephanie Fiedler, James E O'Brien, Jennifer Marshall, Shihui Yu, Hong-Yu Liu
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87472 (2014)
Tetralogy of Fallot (TOF) is one of the most common severe congenital heart malformations. Great progress has been made in identifying key genes that regulate heart development, yet approximately 70% of TOF cases are sporadic and nonsyndromic with no
Externí odkaz:
https://doaj.org/article/32a4633522144023b7815a8de47f0cf0
Autor:
Jennifer A. Marshall, Douglas C. Bittel, Chloe K Nagasawa, James E. O'Brien, Nataliya Kibiryeva
Publikováno v:
Pediatric Cardiology. 41:341-349
The heart is the first major organ to develop during embryogenesis and must receive proper spatiotemporal signaling for proper development. Failure of proper signaling between the first and second heart fields at twenty days gestation contributes to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aab4700d46209fd917243edf9aa75b03
https://doi.org/10.1007/s00246-019-02263-4
https://doi.org/10.1007/s00246-019-02263-4
Autor:
Lance Hsieh, Alison Paquette, Lan Tu, Peter Pastuszko, Vishal Nigam, James E. O'Brien, Douglas C. Bittel, Jennifer A. Marshall, Nataliya Kibiryeva, Kasey C. Vickers
ObjectivesThe systemic inflammation that occurs after exposure to cardiopulmonary bypass (CPB), which is especially severe in neonatal patients, is associated with poorer outcomes and is not well understood. In order to gain deeper insight into how e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b86cd4cc45be5d1ac58087fd9812eb70
https://doi.org/10.1101/2021.08.13.454953
https://doi.org/10.1101/2021.08.13.454953
Autor:
George T. Capone, Lalita Wadhwa, A. J. Agopian, Douglas C. Bittel, Holly Corbitt, Tracie C. Rosser, Roger H. Reeves, David J. Cutler, Benjamin L. Rambo-Martin, Clifford L. Cua, Michael P. Epstein, James E. O'Brien, Cristina E. Trevino, Michael E. Zwick, H. Richard Johnston, Kenneth J. Dooley, Bernard Keavney, Stephanie L. Sherman, Cheryl L. Maslen, Ivan P. Moskowitz, Aaron M. Holleman, Elizabeth Goldmuntz, Peter J. Gruber, Jennifer G. Mulle, Heather J. Cordell, Jai Oberoi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-2 (2021)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dda81e70b7ea2a0eb66602df1f1e3164
https://doi.org/10.1038/s41598-021-94021-x
https://doi.org/10.1038/s41598-021-94021-x
Autor:
Priscilla Ortiz, Michael Filla, Francis Karanu, Lisa Stehno-Bittel, Lindsey Ott, Amy Wysong, Douglas C. Bittel
Publikováno v:
BMC Veterinary Research
BMC Veterinary Research, Vol 17, Iss 1, Pp 1-12 (2021)
BMC Veterinary Research, Vol 17, Iss 1, Pp 1-12 (2021)
Background The source of multipotent stromal cells (MSC) can have a significant influence on the health and expansion capacity of the cells. As the applications for allogeneic MSCs in the treatment of feline diseases increase, the location of the ini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dffa72c44f5d1c2fd114efe47e328385
http://europepmc.org/articles/PMC8281647
http://europepmc.org/articles/PMC8281647
Autor:
Ram Savan, Michael A. Portman, Lan N. Tu, Christopher Benner, Muhammad Nuri, Masaki Kajimoto, Adriana Forero, Douglas C. Bittel, Marta Scatena, Alberto Aliseda, Peter Pastuszko, Jennifer A. Marshall, Kevin Charette, Lance Hsieh, James E. O'Brien, Sarah E Hampson, Vishal Nigam, Nataliya Kibiryeva
Publikováno v:
JCI Insight
JCI Insight, Vol 6, Iss 1 (2021)
JCI Insight, Vol 6, Iss 1 (2021)
Cardiopulmonary bypass (CPB) is required during most cardiac surgeries. CBP drives systemic inflammation and multi-organ dysfunction that is more severe in neonatal patients. Limited understanding of molecular mechanisms underlying CPB-associated inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38486df760157523bf6d4d1356263f2d
https://doi.org/10.1172/jci.insight.141341
https://doi.org/10.1172/jci.insight.141341
Abstract 15916: Role of Small-cajal Body Associated RNAs (scaRNAs) in Regulation of Cardiomyogenesis
Autor:
Sheeja Rajasingh, Rajasingh Johnson, Shivaani Kirankumar, Narasimman Gurusamy, Jayavardini Vasanthan, Douglas C. Bittel, Vinoth Sigamani
Publikováno v:
Circulation. 142
Introduction: The requirement of non-coding RNAs particularly scaRNAs are playing a critical role in alternative splicing and maturation of mRNAs. Dysregulated splicing of mRNAs has been shown to cause heart defects. In this study, we are comparing t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24a932b847ed50fa5eae145c6ce39837
https://doi.org/10.1161/circ.142.suppl_3.15916
https://doi.org/10.1161/circ.142.suppl_3.15916
Autor:
Cristina E. Trevino, Aaron M. Holleman, Holly Corbitt, Cheryl L. Maslen, Tracie C. Rosser, David J. Cutler, H. Richard Johnston, Benjamin L. Rambo-Martin, Jai Oberoi, Kenneth J. Dooley, George T. Capone, Roger H. Reeves, Heather J. Cordell, Bernard D. Keavney, A.J. Agopian, Elizabeth Goldmuntz, Peter J. Gruber, James E. O’Brien, Douglas C. Bittel, Lalita Wadhwa, Clifford L. Cua, Ivan P. Moskowitz, Jennifer G. Mulle, Michael P. Epstein, Stephanie L. Sherman, Michael E. Zwick
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Atrioventricular septal defects (AVSD) are a severe congenital heart defect present in individuals with Down syndrome (DS) at a > 2000-fold increased prevalence compared to the general population. This study aimed to identify risk-associated genes an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af2255d9c9520e2abe93aa1a24f2d0eb
https://doi.org/10.1038/s41598-020-74650-4
https://doi.org/10.1038/s41598-020-74650-4
Autor:
Johnson Rajasingh, Thuy Cao, Saheli Samanta, Douglas C. Bittel, Buddhadeb Dawn, Sheeja Rajasingh
Publikováno v:
Trends in Cardiovascular Medicine. 28:81-90
Small nucleolar RNAs (snoRNAs) are a group of noncoding RNAs that perform various biological functions, including biochemical modifications of other RNAs, precursors of miRNA, splicing, and telomerase activity. The small Cajal body-associated RNAs (s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a64cb4ef5f7ec9aef9689f35ab2433a1
https://doi.org/10.1016/j.tcm.2017.08.002
https://doi.org/10.1016/j.tcm.2017.08.002