Zobrazeno 1 - 10 of 57 pro vyhledávání: '"Douglas C, Cowan"'
1
Akademický článek
Accelerometer-derived sleep metrics in mild and difficult-to-treat asthma
Autor: Varun Sharma, Helen Clare Ricketts, Femke Steffensen, Anna Goodfellow, Duncan S Buchan, Douglas C Cowan
Publikováno v: Allergy, Asthma & Clinical Immunology, Vol 20, Iss 1, Pp 1-4 (2024)
Abstract Introduction Poor sleep health is associated with increased asthma morbidity and mortality. Accelerometers have been validated to assess sleep parameters though studies using this method in patients with asthma are sparse and none have compa
Externí odkaz: https://doaj.org/article/b08313c18a05453abdd13123591c81f6
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2
Akademický článek
A pragmatic randomised controlled trial of tailored pulmonary rehabilitation in participants with difficult-to-control asthma and elevated body mass index
Autor: Helen Clare Ricketts, Varun Sharma, Femke Steffensen, Anna Goodfellow, Elaine Mackay, Gordon MacDonald, Duncan S. Buchan, Rekha Chaudhuri, Douglas C. Cowan
Publikováno v: BMC Pulmonary Medicine, Vol 22, Iss 1, Pp 1-13 (2022)
Abstract Background Difficult-to-control asthma associated with elevated body mass index (BMI) is challenging with limited treatment options. The effects of pulmonary rehabilitation (PR) in this population are uncertain. Methods This is a randomised
Externí odkaz: https://doaj.org/article/df4a8447a0bf46a58395c98f9743d182
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5
Physical activity levels in asthma: relationship with disease severity, body mass index and novel accelerometer-derived metrics
Autor: Helen Clare Ricketts, Duncan S. Buchan, Femke Steffensen, Rekha Chaudhuri, Julien S. Baker, Douglas C. Cowan
Publikováno v: Journal of Asthma. 60:824-834
Patients with asthma may feel limited in physical activity (PA). Reduced PA has been demonstrated in asthmatics versus healthy controls, and increasing PA associated with improved asthma outcomes. Obesity is commonly found with difficult-to-control a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7e76b4c8b7e8e970efd4647418c3b5a
https://doi.org/10.1080/02770903.2022.2102037
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6
Composite type-2 biomarker strategy versus a symptom–risk-based algorithm to adjust corticosteroid dose in patients with severe asthma: a multicentre, single-blind, parallel group, randomised controlled trial
Autor: David C. Jackson, Catherine E. Hanratty, Kian Fan Chung, John G. Matthews, Ratko Djukanovic, Maria Nunez, Robert Niven, Douglas S. Robinson, Liam G Heaney, Michelle Bourne, Catherine Borg, Clare Connolly, Mary Bellamy, Val Hudson, Gareth M. Davies, Christopher E. Brightling, Beverley Hargadon, Traceyanne Grandison, Ian M. Adcock, Sebastian L. Johnston, Rekha Chaudhuri, Geraldine Jones, James Lordan, Andrew Menzies-Gow, Adnam Azim, Dominic E. Shaw, John Busby, Ashley Woodcock, Freda Yang, Peter Bradding, Christopher Corrigan, David F. Choy, Cecile T.J. Holweg, Douglas C. Cowan, Paula McCourt, Tim Harrison, Peter H. Howarth, AH Mansur, Joel Solis, Avril Horn, Joseph R. Arron, Gabrielle Gainsborough, Sarah E Davies, Stephen J. Fowler, Roisin Stone, Timothy C. Hardman, Ian D. Pavord, Samantha Walker, Richard W. Costello, Katherine C. Smith
Publikováno v: The Lancet. Respiratory Medicine
Heaney, L G, Busby, J, Hanratty, C E, Djukanovic, R, Woodcock, A, Walker, S M, Hardman, T C, Arron, J R, Choy, D F, Bradding, P, Brightling, C E, Chaudhuri, R, Cowan, D C, Mansur, A H, Fowler, S J, Niven, R M, Howarth, P H, Lordan, J L, Menzies-Gow, A, Harrison, T W, Robinson, D S, Holweg, C T J, Matthews, J G & Pavord, I D 2020, ' Composite type-2 biomarker strategy versus a symptom-risk-based algorithm to adjust corticosteroid dose in patients with severe asthma: a multicentre, single-blind, parallel group, randomised controlled trial ', The Lancet Respiratory Medicine, vol. 9, no. 1, pp. 57-68 . https://doi.org/10.1016/S2213-2600(20)30397-0
Investigators for the MRC Refractory Asthma Stratification Programme 2020, ' Composite type-2 biomarker strategy versus a symptom-risk-based algorithm to adjust corticosteroid dose in patients with severe asthma : a multicentre, single-blind, parallel group, randomised controlled trial ', The Lancet. Respiratory medicine, vol. 9, no. 1, pp. 57-68 . https://doi.org/10.1016/S2213-2600(20)30397-0
Background: Asthma treatment guidelines recommend increasing corticosteroid dose to control symptoms and reduce exacerbations. This approach is potentially flawed because symptomatic asthma can occur without corticosteroid responsive type-2 (T2)-driv
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5ef6be32c033198e4b8e575dc156cd9
http://europepmc.org/articles/PMC7783382
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7
Obesity affects type 2 biomarker levels in asthma
Autor: Varun Sharma, Helen Clare Ricketts, Femke Steffensen, Anna Goodfellow, Douglas C. Cowan
Objective: Type 2 (T2) inflammation offers a therapeutic target for biologics. Previous trials suggest obesity influences T2-biomarker levels in asthma, though have not accounted for key variables, e.g., inhaled (ICS)/oral corticosteroid (OCS) use. W
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa2c39df2e8db2788a6cc5197fae2eee
https://eprints.gla.ac.uk/266914/1/266914.pdf
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