Zobrazeno 1 - 10 of 16 pro vyhledávání: '"Douglas Buckley"'
1
Akademický článek
FASN inhibition targets multiple drivers of NASH by reducing steatosis, inflammation and fibrosis in preclinical models
Autor: Marie O’Farrell, Greg Duke, Richard Crowley, Douglas Buckley, Eduardo B. Martins, Dipankar Bhattacharya, Scott L. Friedman, George Kemble
Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Fatty acid synthase (FASN) is an attractive therapeutic target in non-alcoholic steatohepatitis (NASH) because it drives de novo lipogenesis and mediates pro-inflammatory and fibrogenic signaling. We therefore tested pharmacological inhibiti
Externí odkaz: https://doaj.org/article/b33eeb880fcb45fca9716afc443aa3b3
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2
Akademický článek
FASN Inhibition and Taxane Treatment Combine to Enhance Anti-tumor Efficacy in Diverse Xenograft Tumor Models through Disruption of Tubulin Palmitoylation and Microtubule Organization and FASN Inhibition-Mediated Effects on Oncogenic Signaling and Gene Expression
Autor: Timothy S. Heuer, Richard Ventura, Kasia Mordec, Julie Lai, Marina Fridlib, Douglas Buckley, George Kemble
Publikováno v: EBioMedicine, Vol 16, Iss C, Pp 51-62 (2017)
Palmitate, the enzymatic product of FASN, and palmitate-derived lipids support cell metabolism, membrane architecture, protein localization, and intracellular signaling. Tubulins are among many proteins that are modified post-translationally by acyla
Externí odkaz: https://doaj.org/article/6f1c25fe440a4d5bb962bf5f6a378714
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3
Akademický článek
Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gene Expression
Autor: Richard Ventura, Kasia Mordec, Joanna Waszczuk, Zhaoti Wang, Julie Lai, Marina Fridlib, Douglas Buckley, George Kemble, Timothy S. Heuer
Publikováno v: EBioMedicine, Vol 2, Iss 8, Pp 808-824 (2015)
Inhibition of de novo palmitate synthesis via fatty acid synthase (FASN) inhibition provides an unproven approach to cancer therapy with a strong biological rationale. FASN expression increases with tumor progression and associates with chemoresistan
Externí odkaz: https://doaj.org/article/28834e3476c148f1a56469f98d334506
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4
Fatty Acid Synthase Inhibitor TVB‐2640 Reduces Hepatic de Novo Lipogenesis in Males With Metabolic Abnormalities
Autor: Camila Manrique-Acevedo, George Kemble, Douglas Buckley, Elizabeth J. Parks, Ayman H. Gaballah, Ghassan M. Hammoud, Majid M. Syed-Abdul, William McCulloch, Kimberlee Bingham
Publikováno v: Hepatology. 72:103-118
Background and aims Elevated hepatic de novo lipogenesis (DNL) is a key distinguishing characteristic of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis. In rodent models of NAFLD, treatment with a surrogate of TVB-2640, a p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11b34394429ce8afa603ec5bf9add360
https://doi.org/10.1002/hep.31000
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5
Fatty acid synthase – Modern tumor cell biology insights into a classical oncology target
Autor: Allan S. Wagman, George Kemble, Gregory Duke, Marie O'Farrell, William McCulloch, Timothy S. Heuer, Douglas Buckley
Publikováno v: Pharmacology & Therapeutics. 177:23-31
Decades of preclinical and natural history studies have highlighted the potential of fatty acid synthase (FASN) as a bona fide drug target for oncology. This review will highlight the foundational concepts upon which this perspective is built. Publis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f32235cccfed311e7c601c9683c5407
https://doi.org/10.1016/j.pharmthera.2017.02.021
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6
FASN Inhibition and Taxane Treatment Combine to Enhance Anti-tumor Efficacy in Diverse Xenograft Tumor Models through Disruption of Tubulin Palmitoylation and Microtubule Organization and FASN Inhibition-Mediated Effects on Oncogenic Signaling and Gene Expression
Autor: Douglas Buckley, Timothy S. Heuer, Julie Lai, George Kemble, Kasia Mordec, Richard Benn Abegania Ventura, Marina Fridlib
Publikováno v: EBioMedicine, Vol 16, Iss C, Pp 51-62 (2017)
EBioMedicine
Palmitate, the enzymatic product of FASN, and palmitate-derived lipids support cell metabolism, membrane architecture, protein localization, and intracellular signaling. Tubulins are among many proteins that are modified post-translationally by acyla
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4a802f596b8c80bcd58cda8b58cc926
http://www.sciencedirect.com/science/article/pii/S2352396416305916
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7
Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gene Expression
Autor: Joanna Waszczuk, Marina Fridlib, Zhaoti Wang, Kasia Mordec, Douglas Buckley, Richard Benn Abegania Ventura, Julie Lai, George Kemble, Timothy S. Heuer
Publikováno v: EBioMedicine
EBioMedicine, Vol 2, Iss 8, Pp 808-824 (2015)
Inhibition of de novo palmitate synthesis via fatty acid synthase (FASN) inhibition provides an unproven approach to cancer therapy with a strong biological rationale. FASN expression increases with tumor progression and associates with chemoresistan
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::580e0e766ed39e539cb71c538bdb6fe4
http://europepmc.org/articles/PMC4563160
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10
Abstract 4743: Preclinical studies characterize tumor type sensitivity to FASN inhibition and the mechanism and efficacy of novel drug combinations with TVB-2640
Autor: Timothy S. Heuer, Richard Benn Abegania Ventura, Douglas Buckley, Julie Lai, George Kemble, Claudia Rubio, Joanna Waszczuk, Glenn Hammonds, Marie O' Farrell
Publikováno v: Cancer Research. 76:4743-4743
Tumor cells have an increased dependence on FASN-synthesized palmitate compared to non-tumor cells, which obtain many of their required lipids from the extracellular milieu. Palmitate and palmitate-derived lipids comprise diverse cellular components
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe52e901a732df1da92bdb9825451f7a
https://doi.org/10.1158/1538-7445.am2016-4743
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