Capacitance spectroscopy enables real-time monitoring of early cell death in mammalian cell culture

Autor: Suyang Wu, Stephanie A Ketcham, Claudia C. Corredor, Douglas Both, James K. Drennen, Carl A. Anderson

Publikováno v: Biotechnology journal.

Previous work developed a quantitative model using capacitance spectroscopy in an at-line setup to predict the dying cell percentage measured from a flow cytometer. This work aimed to transfer the at-line model to monitor lab-scale bioreactors in rea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74a2be7640504c8c5d6b274c1008f51e
https://pubmed.ncbi.nlm.nih.gov/36479620

Real‐time monitoring of quality attributes by in‐line Fourier transform infrared spectroscopic sensors at ultrafiltration and diafiltration of bioprocess

Autor: Zheng Jian Li, Dhanuka P. Wasalathanthri, Letha Chemmalil, Hasin Feroz, Douglas Both, Gregory Lane, Jessica Hung, Melissa Holstein, Julia Ding, Neha Puri, Sanchayita Ghose

Publikováno v: Biotechnology and Bioengineering. 117:3766-3774

Technologies capable of monitoring product quality attributes and process parameters in real time are becoming popular due to the endorsement of regulatory agencies and also to support the agile development of biotherapeutic pipelines. The utility of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::698e7ff3bb1a368036c96c9d80bbf4c8
https://doi.org/10.1002/bit.27532

Contributors

Autor: Vivek Agrahari, Sherif I.F. Badawy, Garima Balwani, Arvind K. Bansal, Dilbir Bindra, Douglas Both, Jamie Clayton, Stephen Cole, Michael Delancy, Atul Dubey, Jiangnan Dun, Thomas Dürig, Leon Farber, Tim Freeman, Dhaval K. Gaglani, Zhihui Gao, Shruti Gour, Praveen Hiremath, Mario Hubert, Munir Hussain, Kapish Karan, Rekha Keluskar, Keirnan R. LaMarche, Richard D. LaRoche, Jinjiang Li, Judy Lin, Kevin Macias, Doug Millington-Smith, Hideya Nakamura, Ajit S. Narang, Kalyan Nuguru, Preetanshu Pandey, Srinivasa Paruchuri, Maneesha Patil, Carlos O. Paz, Rohit Ramachandran, Bhagwant D. Rege, Brenda Remy, Susan Rosencrance, Abu T.M. Serajuddin, Keyur R. Shah, Ankita V. Shah, Pankaj A. Shah, Sneha Sheokand, Valery Sheverev, Anna Sosnowska, Vadim Stepaniuk, Tim Stevens, Ganeshkumar A. Subramanian, Changquan Calvin Sun, Madhu S. Surapaneni, Marta M. Szemraj, Li Tao, Yue Teng, Sailesh A. Varia, Chandra Vemavarapu, Rajan Verma, Jonathan B. Wade, Satoru Watano, Abraham E. Wolf, Xiang Yu, Lawrence X. Yu, Junshu Zhao

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e1e178c26672be9b0b9d800c620c0001
https://doi.org/10.1016/b978-0-12-810460-6.09992-9

Analytical Method Quality by Design for an On-Line Near-Infrared Method to Monitor Blend Potency and Uniformity

Autor: Ryan McCann, Ruben Lozano, Pankaj Shah, Xin Bu, Douglas Both, Tim Stevens, Jeffrey Dougherty, Claudia C. Corredor

Publikováno v: Journal of Pharmaceutical Innovation. 10:47-55

In this work, an example of analytical method quality by design (AQbD) principles applied to an in-line NIR method to monitor blend potency and uniformity in the manufacturing of an oral solid dosage product is presented. An integrated process analyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a18cd0298297dee56552f56cb55e8d4f
https://doi.org/10.1007/s12247-014-9205-2

Cetus 840®: A New Paradigm for a Modernized Fully Automated Dissolution System

Autor: Khanh Ha, Scott P. Jennings, Douglas Both

Publikováno v: Journal of Pharmaceutical Innovation. 4:107-114

Fully automated dissolution test systems have become common throughout the pharmaceutical industry, and they are frequently utilized in laboratories that have a high sample throughput such as stability testing and quality control laboratories. Althou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d764b502fa39d13dd892d9b0fce18aba
https://doi.org/10.1007/s12247-009-9062-6