Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Douglas Barnas"'
Autor:
Francesca T. Aweeka, Robert W. Coombs, David M. Margolis, David W. Haas, Sarah Palmer, Diane V. Havlir, Zhaohui Su, Sheran S. Patel, Gene D. Morse, Douglas Barnas, John M. Coffin, C. Bradley Hare, John W. Mellors, Lisa M. Frenkel, Amy Krambrink, Valerie F. Boltz, Daniel J. Skiest
Publikováno v:
Clinical Infectious Diseases. 47:421-424
Using standard and ultrasensitive techniques, we detected nonnucleoside reverse-transcriptase inhibitor-associated resistance mutations in 11 (20%) of 54 subjects who discontinued virologically suppressive nonnucleoside reverse-transcriptase inhibito
Autor:
Dianna Koontz, Douglas Barnas, Christian J. Bixby, Holly Bazmi, John W. Mellors, Joseph G. Jemsek
Background The rapid failure of initial therapy with combinations of nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) that exclude zidovudine has not been fully explained by standard virus population analyses of HIV type-1 (HIV-1) drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6db4ead254b1301a7dc19c37f4ceecef
https://europepmc.org/articles/PMC2902251/
https://europepmc.org/articles/PMC2902251/
Publikováno v:
The Journal of infectious diseases. 194(5)
Prior virologic and biochemical studies have shown phenotypic antagonism between K65R and multiple thymidine-analogue mutations (TAMs) in site-directed mutants tested in vitro. We hypothesized, on the basis of this observed antagonism, that K65R and