Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Douglas B. Tully"'
Autor:
David J. Dix, Guobin Sun, S.-F. Thai, Douglas B. Tully, Stephen Nesnow, Guy R. Lambert, Rachel D. Grindstaff
Publikováno v:
Xenobiotica. 37:180-193
This study was undertaken to examine the inductive effects of two triazole antifungal agents, myclobutanil and triadimefon, on the expression of hepatic cytochrome P450 (CYP) genes and on the activities of CYP enzymes in male Sprague–Dawley rats. R
Autor:
Michael G. Narotsky, Carmen R. Wood, Judith E. Schmid, Chad R. Blystone, Hongzu Ren, Wenjun Bao, Deborah S. Best, David J. Dix, John C Rockett, Amber K. Goetz, Douglas C. Wolf, Douglas B. Tully, Lillian F. Strader
Publikováno v:
Toxicology and Applied Pharmacology. 215:260-273
Four triazole fungicides were studied using toxicogenomic techniques to identify potential mechanisms of action. Adult male Sprague-Dawley rats were dosed for 14 days by gavage with fluconazole, myclobutanil, propiconazole, or triadimefon. Following
Autor:
J. Christopher Luft, Douglas B. Tully, John C Rockett, David J. Dix, Judith E. Schmid, Carmen R. Wood, Hongzu Ren
Publikováno v:
Reproductive Toxicology. 19:353-366
A byproduct of drinking water disinfection, bromochloroacetic acid (BCA), acts as a reproductive toxicant in rats. To determine if BCA produces similar reproductive toxicity in mice, juvenile and adult C57BL/6 males were exposed to 0, 8, 24, 72 or 21
Publikováno v:
Reproductive Toxicology. 14:95-102
There have been increasing concerns that environmental chemicals may adversely affect the health of humans and wildlife by acting as endocrine modulators. These concerns have been augmented by the realization that human exposure occurs not just to si
Publikováno v:
The FASEB Journal. 8:343-349
Gene transcription mediated by steroid hormones has become one of the most extensively characterized model systems for studying the regulation of gene expression in eukaryotic cells. However, specific details of gene regulation by steroid hormones ar
Autor:
Douglas B. Tully, John A. Cidlowski
Publikováno v:
Biochemistry. 29:6662-6670
Sucrose density gradient shift assays were adapted to permit determination of the affinity of interaction between human glucocorticoid receptors (GR) and DNA under conditions of DNA excess. Saturation analyses were performed to ascertain dissociation
Autor:
Amber K. Goetz, Sheau-Fung Thai, Guobin Sun, David J. Dix, Michael H. George, Stephen Nesnow, Rachel D. Grindstaff, Douglas B. Tully, Douglas C. Wolf, Guy R. Lambert
Publikováno v:
Toxicology letters. 164(1)
This study was undertaken to examine the effects of the triazole antifungal agent fluconazole on the expression of hepatic cytochrome P450 (Cyp) genes and the activities of Cyp enzymes in male Sprague-Dawley rats and male CD-1 mice. Alkoxyresorufin O
Autor:
Amber K. Goetz, Douglas C. Wolf, Stephen Nesnow, Sheau-Fung Thai, Guobin Sun, David J. Dix, Douglas B. Tully, Guy R. Lambert
Publikováno v:
Toxicology letters. 155(2)
Propiconazole is a N-substituted triazole used as a fungicide on fruits, grains, seeds, hardwoods, and conifers. In the present study, propiconazole was examined for its effects on the expression of hepatic cytochrome P450 genes and on the activities
Publikováno v:
Journal of human lactation : official journal of International Lactation Consultant Association. 17(2)
Breastfeeding and human milk are widely recognized as optimal for human infants. However, if donor milk is used when mother's own milk is not available, some questions arise concerning the effects of storage, handling, and heat processing on the uniq
Autor:
J Diane Overstreet, Robert E. Chapin, Douglas B. Tully, Gregg E. Dinse, Moiz Mumtaz, Bradley J. Collins, Cynthia S. Smith
Publikováno v:
Toxicology and applied pharmacology. 168(2)
Toxic metals occur naturally at low concentrations throughout the environment, but are found in higher concentrations at many of the hazardous waste sites on the EPA Superfund list. As part of the Agency for Toxic Substances and Disease Registry (ATS