Zobrazeno 1 - 10
of 283
pro vyhledávání: '"Douglas B. Sawyer"'
Autor:
Joanne T. deKay, Ivette F. Emery, Jonathan Rud, Ashley Eldridge, Christine Lord, David J. Gagnon, Teresa L. May, Victoria L. M. Herrera, Nelson Ruiz-Opazo, Richard R. Riker, Douglas B. Sawyer, Sergey Ryzhov, David B. Seder
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract SARS-CoV-2 infection results in a spectrum of outcomes from no symptoms to widely varying degrees of illness to death. A better understanding of the immune response to SARS-CoV-2 infection and subsequent, often excessive, inflammation may in
Externí odkaz:
https://doaj.org/article/7f8cafdfa06e450c8c3f9913a5c5c788
Modification of ventriculo–arterial coupling by spironolactone in nonischemic dilated cardiomyopathy
Autor:
Mark A. Lawson, David E. Hansen, Deepak K. Gupta, Susan P. Bell, Douglas W. Adkisson, Ravinder R. Mallugari, Douglas B. Sawyer, Henry Ooi, Marvin W. Kronenberg
Publikováno v:
ESC Heart Failure, Vol 8, Iss 2, Pp 1156-1166 (2021)
Abstract Aims We sought to clarify the role of ventriculo–arterial (V–A) coupling in the treatment of nonischemic dilated cardiomyopathy (NIDCM) by adding a mineralocorticoid receptor antagonist (MRA) to conventional anti‐failure therapy. Metho
Externí odkaz:
https://doaj.org/article/b5360629d2794222a6879e6ae79cc218
Publikováno v:
Cardio-Oncology, Vol 5, Iss 1, Pp 1-10 (2019)
Abstract Background Anthracycline chemotherapy is an effective and widely used treatment for solid tumors and hematological malignancies regardless of its known cardiotoxicity. The mechanisms of the cardiotoxicity are not fully understood and methods
Externí odkaz:
https://doaj.org/article/5b7b77d9a2ff49d89e351124dfd11486
Autor:
Cristi L. Galindo, Van Thuan Nguyen, Braxton Hill, Ethan Easterday, John H. Cleator, Douglas B. Sawyer
Publikováno v:
Biology, Vol 11, Iss 5, p 682 (2022)
Neuregulin-1β (NRG-1β) is a growth and differentiation factor with pleiotropic systemic effects. Because NRG-1β has therapeutic potential for heart failure and has known growth effects in skeletal muscle, we hypothesized that it might affect heart
Externí odkaz:
https://doaj.org/article/4b93cf3be5624b8a9c83d11b95ef69c1
Autor:
Rebecca N. Hutchinson, Caitlin Gutheil, Benjamin S. Wessler, Hayley Prevatt, Douglas B. Sawyer, Paul K. J. Han
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 18 (2020)
Background Advanced heart failure (AHF) carries a morbidity and mortality that are similar or worse than many advanced cancers. Despite this, there are no accepted quality metrics for end‐of‐life (EOL) care for patients with AHF. Methods and Resu
Externí odkaz:
https://doaj.org/article/e06c03952dc94f6d8895f8d70537e7e2
Autor:
Philippe Beauchamp, Christopher B. Jackson, Lijo Cherian Ozhathil, Irina Agarkova, Cristi L. Galindo, Douglas B. Sawyer, Thomas M. Suter, Christian Zuppinger
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
Purpose: Both cardiomyocytes and cardiac fibroblasts (CF) play essential roles in cardiac development, function, and remodeling. Properties of 3D co-cultures are incompletely understood. Hence, 3D co-culture of cardiomyocytes and CF was characterized
Externí odkaz:
https://doaj.org/article/3a3586fc1a7f41ffb064131b5554a5c2
Autor:
Larry W. Markham, Candice L. Brinkmeyer-Langford, Jonathan H. Soslow, Manisha Gupte, Douglas B. Sawyer, Joe N. Kornegay, Cristi L. Galindo
Publikováno v:
BMC Medical Genomics, Vol 10, Iss 1, Pp 1-12 (2017)
Abstract Background Duchenne muscular dystrophy (DMD) is caused by mutations in the DMD gene, which codes for the dystrophin protein. While progress has been made in defining the molecular basis and pathogenesis of DMD, major gaps remain in understan
Externí odkaz:
https://doaj.org/article/6f852da7d2e2474a811eccd2294ee126
Autor:
Douglas B. Sawyer, MD, PhD
Publikováno v:
JACC. CardioOncology, Vol 2, Iss 3, Pp 489-490 (2020)
Externí odkaz:
https://doaj.org/article/0b4247bf270e4dc99c8f2c7ffadf2c10
Autor:
Daniel J. Lenihan, MD, Sarah A. Anderson, ACNP, Carrie Geisberg Lenneman, MD, Evan Brittain, MD, MSCI, James A.S. Muldowney, III, MD, Lisa Mendes, MD, Ping Z. Zhao, PhD, Jennifer Iaci, MS, Stephen Frohwein, MD, Ronald Zolty, MD, PhD, Andrew Eisen, MD, PhD, Douglas B. Sawyer, MD, PhD, Anthony O. Caggiano, MD, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 1, Iss 7, Pp 576-586 (2016)
A first-in-human, phase 1, double blind, placebo-controlled, single ascending dose study examined the safety, tolerability, and exploratory efficacy of intravenous infusion of a recombinant growth factor, cimaglermin alfa, in patients with heart fail
Externí odkaz:
https://doaj.org/article/1b06ca8dbecb4850b7f6c85e6a80bdc0
Autor:
Sergey Ryzhov, Teresa May, John Dziodzio, Ivette F. Emery, F. L. Lucas, Angela Leclerc, Barbara McCrum, Christine Lord, Ashley Eldridge, Michel P. Robich, Fumito Ichinose, Douglas B. Sawyer, Richard Riker, David B. Seder
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 13 (2019)
Background Patients resuscitated from cardiac arrest (CA) have highly variable neurological, circulatory, and systemic ischemia‐reperfusion injuries. After the initial hypoxic‐ischemic insult, a cascade of immune and inflammatory responses develo
Externí odkaz:
https://doaj.org/article/a9dc04fd83d043d69d0af1e74158359c