Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Douglas B. Fox"'
Autor:
Douglas B. Fox, Richard Y. Ebright, Xin Hong, Hunter C. Russell, Hongshan Guo, Thomas J. LaSalle, Ben S. Wittner, Nicolas Poux, Joanna A. Vuille, Mehmet Toner, Nir Hacohen, Genevieve M. Boland, Debattama R. Sen, Ryan J. Sullivan, Shyamala Maheswaran, Daniel A. Haber
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-7 (2023)
Abstract Immune checkpoint blockade (ICB) has demonstrated efficacy in patients with melanoma, but many exhibit poor responses. Using single cell RNA sequencing of melanoma patient-derived circulating tumor cells (CTCs) and functional characterizatio
Externí odkaz:
https://doaj.org/article/0c4c7c44430b4c2d974ab834570483bb
Autor:
Andrea Walens, Jiaxing Lin, Jeffrey S. Damrauer, Brock McKinney, Ryan Lupo, Rachel Newcomb, Douglas B. Fox, Nathaniel W. Mabe, Jeremy Gresham, Zhecheng Sheng, Alexander B. Sibley, Tristan De Buysscher, Hemant Kelkar, Piotr A. Mieczkowski, Kouros Owzar, James V. Alvarez
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The cellular composition of recurrent tumors can provide insight into resistance to therapy and inform on second line therapies. Here, using a genetically modified mouse, the authors perform barcoding experiments of the primary tumors to allow them t
Externí odkaz:
https://doaj.org/article/88169f662d1448619437707b70a98494
Autor:
Eoin McDonnell, Scott B. Crown, Douglas B. Fox, Betül Kitir, Olga R. Ilkayeva, Christian A. Olsen, Paul A. Grimsrud, Matthew D. Hirschey
Publikováno v:
Cell Reports, Vol 17, Iss 6, Pp 1463-1472 (2016)
Cells integrate nutrient sensing and metabolism to coordinate proper cellular responses to a particular nutrient source. For example, glucose drives a gene expression program characterized by activating genes involved in its metabolism, in part by in
Externí odkaz:
https://doaj.org/article/7468bd7b52bb47b7833fa642f2a1852f
Autor:
Nirmala Ramanujam, James V. Alvarez, Amy F. Martinez, Caigang Zhu, Jihong Lee, Brian T. Crouch, Douglas B. Fox, Megan C. Madonna
With the large number of women diagnosed and treated for breast cancer each year, the importance of studying recurrence has become evident due to most deaths from breast cancer resulting from tumor recurrence following therapy. To mitigate this, cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34bf17580a05ac172615346548f0c5d0
https://doi.org/10.1158/1541-7786.c.6541071
https://doi.org/10.1158/1541-7786.c.6541071
Autor:
Nirmala Ramanujam, James V. Alvarez, Amy F. Martinez, Caigang Zhu, Jihong Lee, Brian T. Crouch, Douglas B. Fox, Megan C. Madonna
Supplementary Figure 1: 3D Rendering of mammosphere stained with 2-NBDG and TMRE. Supplementary Figure 2: Western blot confirms loss of Her2 expression following withdrawal of Dox in media conditions. Supplementary Figure 3: Quantification of immunoh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38d05004213c4781388023c57c8fac7d
https://doi.org/10.1158/1541-7786.22515396
https://doi.org/10.1158/1541-7786.22515396
Autor:
Daniel A. Haber, Mehmet Toner, Shyamala Maheswaran, Ravi Kapur, Shannon L. Stott, Jeffrey A. Engelman, John R. Walsh, Thomas A. Barber, Bruce E. Johnson, Wen Wei, Helena A. Yu, Martin Fleisher, Uma Giri, Hai T. Tran, Andrew Webb, Alona Muzikansky, Robert Maher, Douglas B. Fox, James P. Sullivan, Walter H. Koch, Pasi A. Jänne, Gregory J. Riely, John V. Heymach, Lecia V. Sequist, Tilak K. Sundaresan
Supplementary tables S1-S3. Supplementary Table S1: Institutional Tumor Genotyping Strategies. Supplementary Table S2: T790M Genotype by Modality. Supplementary Table S3: EGFR Primary Mutation Detection.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::872af2d4534314744579a6b80c0fd5be
https://doi.org/10.1158/1078-0432.22457103.v1
https://doi.org/10.1158/1078-0432.22457103.v1
Autor:
Daniel A. Haber, Mehmet Toner, Shyamala Maheswaran, Ravi Kapur, Shannon L. Stott, Jeffrey A. Engelman, John R. Walsh, Thomas A. Barber, Bruce E. Johnson, Wen Wei, Helena A. Yu, Martin Fleisher, Uma Giri, Hai T. Tran, Andrew Webb, Alona Muzikansky, Robert Maher, Douglas B. Fox, James P. Sullivan, Walter H. Koch, Pasi A. Jänne, Gregory J. Riely, John V. Heymach, Lecia V. Sequist, Tilak K. Sundaresan
Purpose: The T790M gatekeeper mutation in the EGFR is acquired by some EGFR-mutant non–small cell lung cancers (NSCLC) as they become resistant to selective tyrosine kinase inhibitors (TKI). As third-generation EGFR TKIs that overcome T790M-associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::045e97714a002cfa707153c4c4fce05c
https://doi.org/10.1158/1078-0432.c.6523506
https://doi.org/10.1158/1078-0432.c.6523506
Autor:
Erin J. Silva, Daniel A. Haber, Taronish D. Dubash, Shyamala Maheswaran, Ravi Kapur, Matthew Liebers, Nicola Aceto, Zongli Zheng, Douglas B. Fox, John Iafrate, Ben S. Wittner, Mehmet Toner, Aditya Bardia, Tilak K. Sundaresan
Publikováno v:
Breast Cancer Res Treat
PURPOSE: Therapeutic efficacy of hormonal therapies to target estrogen receptor (ER)-positive breast cancer is limited by the acquisition of ligand-independent ESR1 mutations, which confer treatment resistance to aromatase inhibitors (AIs). Monitorin
Autor:
Jason W. Locasale, Laura C. Noteware, Brock McKinney, Ryan Lupo, Rachel Newcomb, James V. Alvarez, Douglas B. Fox, Matthew D. Hirschey, Juan Liu, Nina Marie G. Garcia
Publikováno v:
Nature metabolism
The survival and recurrence of dormant tumour cells following therapy is a leading cause of death in cancer patients. The metabolic properties of these cells are likely distinct from those of rapidly growing tumours. Here we show that Her2 down-regul
Autor:
James V. Alvarez, Douglas B. Fox
Branched-chain amino acid metabolism has emerged as a crucial regulator of tumor proliferation. In particular, the branched-chain amino acid transaminase 1 (BCAT1), which catalyzes the conversion of branched-chain amino acids to α-keto acids in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::353e460e9c94258d28f4f065833a248f
https://doi.org/10.1101/2020.12.08.416479
https://doi.org/10.1101/2020.12.08.416479