Zobrazeno 1 - 10
of 433
pro vyhledávání: '"Douglas B. Cines"'
Platelet factor 4 (CXCL4/PF4) upregulates matrix metalloproteinase-2 (MMP-2) in gingival fibroblasts
Autor:
Hoa T. Le, Kalyan Golla, Ryan Karimi, Michael R. Hughes, Flavia Lakschevitz, Douglas B. Cines, M. Anna Kowalska, Mortimer Poncz, Kelly M. McNagny, Lari Häkkinen, Hugh Kim
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Periodontitis is a chronic inflammatory disease characterized by the release of matrix metalloproteinases (MMPs) from resident connective tissue cells in tooth-supporting tissues (periodontium). Platelet activation, and the attendant release
Externí odkaz:
https://doaj.org/article/c2467ba58de749a98460d3e7a5fb6c55
Autor:
Yi Na Dong, Fu-Chun Hsu, Cynthia J. Koziol-White, Victoria Stepanova, Joseph Jude, Andrei Gritsiuta, Ryan Rue, Rosalind Mott, Douglas A. Coulter, Reynold A. Panettieri, Vera P. Krymskaya, Hajime Takano, Elena A. Goncharova, Dmitry A. Goncharov, Douglas B. Cines, David R. Lynch
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract N-methyl-d-aspartate (NMDA) receptors are widely expressed in the central nervous system. However, their presence and function at extraneuronal sites is less well characterized. In the present study, we examined the expression of NMDA recept
Externí odkaz:
https://doaj.org/article/8bd4b029a3e741f88fc9ecbfcf332be3
Autor:
Irina N. Chernysh, Chandrasekaran Nagaswami, Sofia Kosolapova, Alina D. Peshkova, Adam Cuker, Douglas B. Cines, Carolyn L. Cambor, Rustem I. Litvinov, John W. Weisel
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Abstract Although arterial and venous thromboembolic disorders are among the most frequent causes of mortality and morbidity, there has been little description of how the composition of thrombi and emboli depends on their vascular origin and age. We
Externí odkaz:
https://doaj.org/article/12086ecd9aa2460989bafb505ae629db
Autor:
Cindy Neunert, Deirdra R. Terrell, Donald M. Arnold, George Buchanan, Douglas B. Cines, Nichola Cooper, Adam Cuker, Jenny M. Despotovic, James N. George, Rachael F. Grace, Thomas Kühne, David J. Kuter, Wendy Lim, Keith R. McCrae, Barbara Pruitt, Hayley Shimanek, Sara K. Vesely
Publikováno v:
Blood Advances, Vol 3, Iss 23, Pp 3829-3866 (2019)
Abstract: Background: Despite an increase in the number of therapies available to treat patients with immune thrombocytopenia (ITP), there are minimal data from randomized trials to assist physicians with the management of patients.Objective: These e
Externí odkaz:
https://doaj.org/article/61b0918c8aaf4076a09ba65bc53595e5
Autor:
Galina Florova, René A. Girard, Ali O. Azghani, Krishna Sarva, Ann Buchanan, Sophia Karandashova, Christian J. DeVera, Danna Morris, Mignote Chamiso, Kathleen Koenig, Douglas B. Cines, Steven Idell, Andrey A. Komissarov
Publikováno v:
Physiological Reports, Vol 9, Iss 9, Pp n/a-n/a (2021)
Abstract Plasminogen activator inhibitor‐1 (PAI‐1) is an endogenous irreversible inhibitor of tissue‐type (tPA) and urokinase (uPA) plasminogen activators. PAI‐1‐targeted fibrinolytic therapy (PAI‐1‐TFT) is designed to decrease the ther
Externí odkaz:
https://doaj.org/article/386765511fda4d219e19f23621bdbcd5
Autor:
Nichola Cooper, Douglas B. Cines
Publikováno v:
Haematologica, Vol 104, Iss 11 (2019)
Externí odkaz:
https://doaj.org/article/2cc1af5fa2974dc5802031adeab201c1
Autor:
Carlos H. Villa, Daniel C. Pan, Ian H. Johnston, Colin F. Greineder, Landis R. Walsh, Elizabeth D. Hood, Douglas B. Cines, Mortimer Poncz, Don L. Siegel, Vladimir R. Muzykantov
Publikováno v:
Blood Advances, Vol 2, Iss 3, Pp 165-176 (2018)
Abstract: Carriage of drugs by red blood cells (RBCs) modulates pharmacokinetics, pharmacodynamics, and immunogenicity. However, optimal targets for attaching therapeutics to human RBCs and adverse effects have not been studied. We engineered nonhuma
Externí odkaz:
https://doaj.org/article/a2921fc5daff4bd8bbb9bbefa4a0a492
Autor:
Colin F. Greineder, Ian H. Johnston, Carlos H. Villa, Kandace Gollomp, Charles T. Esmon, Douglas B. Cines, Mortimer Poncz, Vladimir R. Muzykantov
Publikováno v:
Blood Advances, Vol 1, Iss 18, Pp 1452-1465 (2017)
Abstract: Diverse human illnesses are characterized by loss or inactivation of endothelial thrombomodulin (TM), predisposing to microvascular inflammation, activation of coagulation, and tissue ischemia. Single-chain antibody fragment (scFv)/TM) fusi
Externí odkaz:
https://doaj.org/article/5eaf34428b9e4bf6807c10cf61c2e8ce
Autor:
Douglas B. Cines, Serge V. Yarovoi, Sergei V. Zaitsev, Tatiana Lebedeva, Lubica Rauova, Mortimer Poncz, Gowthami M. Arepally, Sanjay Khandelwal, Victoria Stepanova, Ann H. Rux, Adam Cuker, Cecilia Guo, Linnette Mae Ocariza, Richard J. Travers, Stephanie A. Smith, Hugh Kim, James H. Morrissey, Edward M. Conway
Publikováno v:
Blood Advances, Vol 1, Iss 1, Pp 62-74 (2016)
Abstract: Heparin-induced thrombocytopenia (HIT) is a thrombotic disorder initiated by antibodies to complexes between platelet factor 4 (PF4) and heparin. The risk of recurrent thromboembolism persists after heparin is cleared and platelet activatio
Externí odkaz:
https://doaj.org/article/05425711ef5040eb80a2b8ffcd281b26
Autor:
Douglas B. Cines, Jeffrey Wasser, Francesco Rodeghiero, Beng H. Chong, Michael Steurer, Drew Provan, Roger Lyons, Jaime Garcia-Chavez, Nancy Carpenter, Xuena Wang, Melissa Eisen
Publikováno v:
Haematologica, Vol 102, Iss 8 (2017)
Primary immune thrombocytopenia is an autoimmune disorder characterized by increased platelet destruction and insufficient platelet production without another identified underlying disorder. Splenectomy may alter responsiveness to treatment and/or in
Externí odkaz:
https://doaj.org/article/99ba96c9c8b644159a947ffcdae13c64