Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Douglas B Stairs"'
Autor:
Douglas B Stairs, Mary E Landmesser, Cesar Aliaga, Kun-Ming Chen, Yuan-Wan Sun, Karam El-Bayoumy
Publikováno v:
PLoS ONE, Vol 16, Iss 11, p e0259998 (2021)
One of the major risk factors for head and neck squamous cell carcinoma (HNSCC) is tobacco smoke exposure, but the mechanisms that can account for disease development remain to be fully defined. Utilizing our HNSCC mouse model, we analyzed oral squam
Externí odkaz:
https://doaj.org/article/02182b31ee9b40d995705b76d5196d3c
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0241299 (2020)
Epidermal growth factor receptor (EGFR) plays a vital role in cell division and survival signaling pathways. EGFR is activated in nearly every cancer type, and its high expression in tumors is correlated with poor patient outcome. Altogether, EGFR is
Externí odkaz:
https://doaj.org/article/100cadc6b4564788a7599d206e617f0c
Autor:
Douglas B Stairs, Hiroshi Nakagawa, Andres Klein-Szanto, Shukriyyah D Mitchell, Debra G Silberg, John W Tobias, John P Lynch, Anil K Rustgi
Publikováno v:
PLoS ONE, Vol 3, Iss 10, p e3534 (2008)
Barrett's esophagus is a premalignant condition whereby the normal stratified squamous esophageal epithelium undergoes a transdifferentiation program resulting in a simple columnar epithelium reminiscent of the small intestine. These changes are typi
Externí odkaz:
https://doaj.org/article/81e53679ddfd4097bf3eed1dbd5de685
Autor:
Fiona E. Chalmers, Saie Mogre, Bipin Rimal, Jeongin Son, Andrew D. Patterson, Douglas B. Stairs, Adam B. Glick
Publikováno v:
Developmental Biology. 492:59-70
The IRE1α-XBP1s signaling branch of the unfolded protein response is a well-characterized survival pathway that allows cells to adapt to and resolve endoplasmic reticulum stress. Recent data has broadened our understanding of IRE1α-XBP1s signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::554873f578cb6c7ff7f5b1b1a0a60fca
https://doi.org/10.1016/j.ydbio.2022.09.009
https://doi.org/10.1016/j.ydbio.2022.09.009
Immunohistochemistry of EPC1 3D organotypic cultures. A, 3D cultures were stained for P120CTN and B, E-cadherin. Scale bars = 50μm. n=3.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21ac9027edb26e74bb283c9df0051045
https://doi.org/10.1158/1541-7786.22511601.v1
https://doi.org/10.1158/1541-7786.22511601.v1
Despite recent improvements in treatment for head and neck squamous cell carcinoma (HNSCC), half of all patients with a regional or advanced disease will die within 5 years from diagnosis. Therefore, identification of mechanisms driving the aggressiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db35f3d997b540abc7b6ddaf0a83b97b
https://doi.org/10.1158/1541-7786.c.6539988.v1
https://doi.org/10.1158/1541-7786.c.6539988.v1
Autor:
Hiroshi Nakagawa, Anil K. Rustgi, J. Alan Diehl, Meenhard Herlyn, Andres J. Klein-Szanto, Momo Nakagawa, Ross A. Kalman, Maria E. Vega, Jiri Kalabis, Douglas B. Stairs, Katharine D. Grugan, Carmen Z. Michaylira, Gabrielle S. Wong, Mitsuteru Natsuizaka, Shinya Ohashi
Transforming growth factor-β (TGF-β) is a potent inducer of epithelial to mesenchymal transition (EMT). However, it remains elusive about which molecular mechanisms determine the cellular capacity to undergo EMT in response to TGF-β. We have found
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cea0023389909cb1e2838a5fe6ce09b6
https://doi.org/10.1158/0008-5472.c.6500397
https://doi.org/10.1158/0008-5472.c.6500397
Autor:
Hiroshi Nakagawa, Anil K. Rustgi, J. Alan Diehl, Meenhard Herlyn, Andres J. Klein-Szanto, Momo Nakagawa, Ross A. Kalman, Maria E. Vega, Jiri Kalabis, Douglas B. Stairs, Katharine D. Grugan, Carmen Z. Michaylira, Gabrielle S. Wong, Mitsuteru Natsuizaka, Shinya Ohashi
Supplementary Figures 1-6, Table 1 from Epidermal Growth Factor Receptor and Mutant p53 Expand an Esophageal Cellular Subpopulation Capable of Epithelial-to-Mesenchymal Transition through ZEB Transcription Factors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf058a84607e913ae719c916c529046
https://doi.org/10.1158/0008-5472.22383018.v1
https://doi.org/10.1158/0008-5472.22383018.v1
Publikováno v:
Cancer Research. 83:4936-4936
Background: Carfilzomib (CF) is a 2nd generation proteasome inhibitor with activity in hematologic cancer, but its study in solid tumors like squamous cell carcinoma of the head and neck (SCCHN) is limited. We investigated its antitumor activity in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fccf62b4ab97163c4b3b7f4ee89c37d4
https://doi.org/10.1158/1538-7445.am2023-4936
https://doi.org/10.1158/1538-7445.am2023-4936
Autor:
Jiafen Hu, Karam El-Bayoumy, Vonn Walter, Joshua E. Muscat, Kun Ming Chen, Douglas B. Stairs, John P. Richie, Raphael P. Viscidi, Yuan Wan Sun, Neil D. Christensen
Publikováno v:
Cancer Prev Res (Phila)
Head and neck squamous cell carcinoma (HNSCC) was the 7th most common malignancy worldwide in 2018 and despite therapeutic advances, the overall survival rate for oral squamous cell carcinoma (OSCC; ∼50%) has remained unchanged for decades. The mos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f41c65e38d61583bb0fcb35e07ace66
https://doi.org/10.1158/1940-6207.capr-20-0096
https://doi.org/10.1158/1940-6207.capr-20-0096