Zobrazeno 1 - 10
of 433
pro vyhledávání: '"Douglas B Cines"'
Autor:
Mohamed Higazi, Suhair Abdeen, Rami Abu-Fanne, Samuel N Heyman, Aseel Masarwy, Khalil Bdeir, Emad Maraga, Douglas B Cines, Abd Al-Roof Higazi
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231582 (2020)
Atherosclerosis, the predominant cause of death in well-resourced countries, may develop in the presence of plasma lipid levels within the normal range. Inflammation may contribute to lesion development in these individuals, but the underlying mechan
Externí odkaz:
https://doaj.org/article/7edbc5b3d3f044a396aa794b28049bca
Autor:
Cindy Neunert, Deirdra R. Terrell, Donald M. Arnold, George Buchanan, Douglas B. Cines, Nichola Cooper, Adam Cuker, Jenny M. Despotovic, James N. George, Rachael F. Grace, Thomas Kühne, David J. Kuter, Wendy Lim, Keith R. McCrae, Barbara Pruitt, Hayley Shimanek, Sara K. Vesely
Publikováno v:
Blood Advances, Vol 3, Iss 23, Pp 3829-3866 (2019)
Abstract: Background: Despite an increase in the number of therapies available to treat patients with immune thrombocytopenia (ITP), there are minimal data from randomized trials to assist physicians with the management of patients.Objective: These e
Externí odkaz:
https://doaj.org/article/61b0918c8aaf4076a09ba65bc53595e5
Autor:
Douglas B. Cines, Andreas Greinacher
Publikováno v:
Blood. 141:1659-1665
Within the first months of the COVID-19 vaccination campaign, previously healthy recipients who developed severe thrombosis (often cerebral and/or splanchnic vasculature) and thrombocytopenia typically after adenoviral vector-based vaccination were i
Autor:
Zheng Cai, Khalil Bdeir, Serge V. Yarovoi, Lubica Rauova, Gowthami M. Arepally, Sanjay Khandelwal, Jerome Rollin, Yves Gruel, Sergei Zaitsev, Mortimer Poncz, Mark I. Greene, Douglas B. Cines
Publikováno v:
Journal of Thrombosis and Haemostasis. 21:652-666
Autor:
Ayiesha P. Barnes, Sanjay Khandelwal, Simone Sartoretto, Sooho Myoung, Samuel J. Francis, Grace M. Lee, Lubica Rauova, Douglas B. Cines, Jon T. Skare, Charles E. Booth, Brandon L. Garcia, Gowthami M. Arepally
Publikováno v:
Journal of Thrombosis and Haemostasis. 20:2656-2665
Anti-platelet factor 4 (PF4)/heparin immune complexes that cause heparin-induced thrombocytopenia (HIT) activate complement via the classical pathway. Previous studies have shown that the alternative pathway of complement substantially amplifies the
Autor:
Nichola Cooper, Douglas B. Cines
Publikováno v:
Haematologica, Vol 104, Iss 11 (2019)
Externí odkaz:
https://doaj.org/article/2cc1af5fa2974dc5802031adeab201c1
Autor:
Carlos H. Villa, Daniel C. Pan, Ian H. Johnston, Colin F. Greineder, Landis R. Walsh, Elizabeth D. Hood, Douglas B. Cines, Mortimer Poncz, Don L. Siegel, Vladimir R. Muzykantov
Publikováno v:
Blood Advances, Vol 2, Iss 3, Pp 165-176 (2018)
Abstract: Carriage of drugs by red blood cells (RBCs) modulates pharmacokinetics, pharmacodynamics, and immunogenicity. However, optimal targets for attaching therapeutics to human RBCs and adverse effects have not been studied. We engineered nonhuma
Externí odkaz:
https://doaj.org/article/a2921fc5daff4bd8bbb9bbefa4a0a492
Autor:
Amrita Sarkar, Sanjay Khandelwal, Gavin Koma, Hyunjun Kim, Yves Gruel, Jerome Rollin, Freda H Passam, Geoffrey D. Wool, Gowthami M. Arepally, Douglas B. Cines, Lubica Rauova, Mortimer Poncz
Publikováno v:
Blood Advances.
Heparin-induced thrombocytopenia (HIT) is characterized by thrombocytopenia associated with a highly prothrombotic state due to the development of pathogenic antibodies that recognize human (h) platelet factor 4 (PF4) complexed with various polyanion
Autor:
Colin F. Greineder, Ian H. Johnston, Carlos H. Villa, Kandace Gollomp, Charles T. Esmon, Douglas B. Cines, Mortimer Poncz, Vladimir R. Muzykantov
Publikováno v:
Blood Advances, Vol 1, Iss 18, Pp 1452-1465 (2017)
Abstract: Diverse human illnesses are characterized by loss or inactivation of endothelial thrombomodulin (TM), predisposing to microvascular inflammation, activation of coagulation, and tissue ischemia. Single-chain antibody fragment (scFv)/TM) fusi
Externí odkaz:
https://doaj.org/article/5eaf34428b9e4bf6807c10cf61c2e8ce
Autor:
Douglas B. Cines, Serge V. Yarovoi, Sergei V. Zaitsev, Tatiana Lebedeva, Lubica Rauova, Mortimer Poncz, Gowthami M. Arepally, Sanjay Khandelwal, Victoria Stepanova, Ann H. Rux, Adam Cuker, Cecilia Guo, Linnette Mae Ocariza, Richard J. Travers, Stephanie A. Smith, Hugh Kim, James H. Morrissey, Edward M. Conway
Publikováno v:
Blood Advances, Vol 1, Iss 1, Pp 62-74 (2016)
Abstract: Heparin-induced thrombocytopenia (HIT) is a thrombotic disorder initiated by antibodies to complexes between platelet factor 4 (PF4) and heparin. The risk of recurrent thromboembolism persists after heparin is cleared and platelet activatio
Externí odkaz:
https://doaj.org/article/05425711ef5040eb80a2b8ffcd281b26