Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Douglas A. Thomason"'
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:2615-2620
The synthesis of analogues of tetrahydroquinoline angiotensin II antagonist, ZENECA ZD6888, bearing substituents on the biphenyl ring system is reported. Several of these compounds show comparable or superior activity to ZD6888 in an in vitro beindin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58e911db5f14c3a0a4b1b40741fd4719
https://doi.org/10.1016/s0960-894x(01)80295-x
https://doi.org/10.1016/s0960-894x(01)80295-x
Autor:
Arnold Harry Ratcliffe, J. S. Major, Keith Hopkinson Gibson, Christopher P. Allott, Simon Thomas Russell, Brian B. Masek, Andrew Peter Thomas, A. A. Oldham, David A. Roberts, Douglas A. Thomason
Publikováno v:
Journal of Medicinal Chemistry. 35:877-885
On the basis of an extension of the literature lead 1, a series of benzimidazoles have been synthesized and shown to be angiotensin II (AII) receptor antagonists. The structure-activity relationships of these new antagonists have been explored and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ad48f5186c1940dd36b2bbe4718c863
https://doi.org/10.1021/jm00083a011
https://doi.org/10.1021/jm00083a011