Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Douglas A. Steeber"'
Autor:
Quan Zeng, Michael D. Laiosa, Douglas A. Steeber, Eulandria M. Biddle, Quan Peng, Ching-Hong Yang
Publikováno v:
Molecular Plant-Microbe Interactions, Vol 25, Iss 1, Pp 37-47 (2012)
Dickeya dadantii 3937 is a gram-negative phytopathogenic bacterium that expresses genes encoding a type III secretion system (T3SS) in a bistable pattern when cultured in a homogeneous minimal media. In this work, we further characterized the bistabl
Externí odkaz:
https://doaj.org/article/e8fcaad023b34b6e98e59c754215244d
Autor:
Quan Peng, Shihui Yang, Amy O. Charkowski, Mee-Ngan Yap, Douglas A. Steeber, Noel T. Keen, Ching-Hong Yang
Publikováno v:
Molecular Plant-Microbe Interactions, Vol 19, Iss 4, Pp 451-457 (2006)
Erwinia chrysanthemi 3937 (Ech3937) is a phytopathogenic bacterium with a wide host range. The pectinolytic enzymes secreted by the bacterium and the type III secretion system (T3SS) are essential for full virulence. We used the green fluorescent pro
Externí odkaz:
https://doaj.org/article/0416506913144439b808164a163d8b6d
Autor:
Jawad B. Belayet, Sarah Beamish, Mizzanoor Rahaman, Samer Alanani, Rajdeep S. Virdi, David N. Frick, A. F. M. Towheedur Rahman, Joseph S. Ulicki, Sreya Biswas, Leggy A. Arnold, M. S. Rashid Roni, Eric Y. Cheng, Douglas A. Steeber, Karyn M. Frick, M. Mahmun Hossain
Publikováno v:
J Med Chem
Histone acetylation is a prominent epigenetic modification linked to the memory loss symptoms associated with neurodegenerative disease. The use of existing histone deacetylase inhibitor (HDACi) drugs for treatment is precluded by their weak blood–
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38e52da392db4ac38742625a6dece2af
https://doi.org/10.1021/acs.jmedchem.1c01928
https://doi.org/10.1021/acs.jmedchem.1c01928
Autor:
Amy W Ku, Jason B Muhitch, Colin A Powers, Michael Diehl, Minhyung Kim, Daniel T Fisher, Anand P Sharda, Virginia K Clements, Kieran O'Loughlin, Hans Minderman, Michelle N Messmer, Jing Ma, Joseph J Skitzki, Douglas A Steeber, Bruce Walcheck, Suzanne Ostrand-Rosenberg, Scott I Abrams, Sharon S Evans
Publikováno v:
eLife, Vol 5 (2016)
Myeloid-derived suppressor cells (MDSC) contribute to an immunosuppressive network that drives cancer escape by disabling T cell adaptive immunity. The prevailing view is that MDSC-mediated immunosuppression is restricted to tissues where MDSC co-min
Externí odkaz:
https://doaj.org/article/3703c01018fe4546bf5280e8e6082a72
Publikováno v:
Theranostics, Vol 2, Iss 8, Pp 757-768 (2012)
A multifunctional gold nanorod (GNR)-based nanoplatform for targeted anticancer drug delivery and positron emission tomography (PET) imaging of tumors was developed and characterized. An anti-cancer drug (i.e., doxorubicin (DOX)) was covalently conju
Externí odkaz:
https://doaj.org/article/2ef35d19678144ce8f83089fc4c07589
Autor:
Wujie Zhang, Junhong Chen, Alexander Dyble, Douglas A. Steeber, Rebecca L. Majewski, Kendra Lehman, M. Kaltchev, Xiaoru Guo, Michael J. Wedemeyer, Samuel Stealey
Publikováno v:
Pharmaceutical Development and Technology. 25:260-265
Pectin-based hydrogel microcarriers have shown promise for drug delivery to the colonic region. Microcarriers must remain stable throughout the upper gastrointestinal tract for effective colonic delivery, an issue that traditional pectin-based microc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ccbe201bdeac00d041935bb9d3a9437
https://doi.org/10.1080/10837450.2019.1691591
https://doi.org/10.1080/10837450.2019.1691591
Autor:
Leggy A. Arnold, Brandon N Mikulsky, Mae E. Stepanski, James M. Cook, Douglas C. Stafford, Melissa Schussman, Guanguan Li, Mohammed S. Rashid Roni, Alec T. Huber, Revathi Kodali, Alexander S. Kehoe, Nicolas M Zahn, Douglas A. Steeber
Publikováno v:
Basic Clin Pharmacol Toxicol
We report a 28-day repeat dose immunotoxicity evaluation of investigational drug MIDD0301, a novel oral asthma drug candidate that targets gamma amino butyric acid type A receptors (GABA(A)R) in the lung. The study design employed oral administration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::559a40ab144ac35cc201bea7c7cf750f
https://doi.org/10.1111/bcpt.13206
https://doi.org/10.1111/bcpt.13206
Autor:
Jamison J Grailer, Douglas A Steeber
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75390 (2013)
Inhibitors of vascular endothelial growth factor and its receptors (VEGFRs) are attractive therapeutic candidates for cancer treatment. One such small molecule VEGFR inhibitor, SU5416, limits angiogenesis in vivo and is widely used for investigating
Externí odkaz:
https://doaj.org/article/3b9c8a3619ef45f397c924da85409bd6
Autor:
Eugene C. Butcher, Ania Bogoslowski, Christoph Scheiermann, Craig N. Jenne, Paul Kubes, Woo Young Lee, Douglas A. Steeber, Samer Alanani, David Masopust, Chien Sin Chen, Sathi Wijeyesinghe
Publikováno v:
Journal of Immunology, Vol. 204, No 9 (2020) pp. 2552-2561
The adaptive immune function of lymph nodes is dependent on constant recirculation of lymphocytes. In this article, we identify neutrophils present in the lymph node at steady state, exhibiting the same capacity for recirculation. In germ-free mice,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95fcc98de9e30a7714790cf08a592336
https://pubmed.ncbi.nlm.nih.gov/32205425
https://pubmed.ncbi.nlm.nih.gov/32205425
Autor:
Gloria S. Forkuo, James M. Cook, Gene T. Yocum, Revathi Kodali, Leggy A. Arnold, Rajwana Jahan, Michael Rajesh Stephen, Margaret L. Guthrie, Douglas A. Steeber, Charles W. Emala, Douglas C. Stafford, Olivia B. Yu, Guanguan Li, Nicolas M Zahn, Ted William Harris, Janet L. Fisher, Amanda N. Nieman, M S Rashid Roni
Publikováno v:
Molecular Pharmaceutics. 15:1766-1777
We describe lead compound MIDD0301 for the oral treatment of asthma based on previously developed positive allosteric α(5)β(3)γ(2) selective GABA(A) receptor (GABA(A)R) ligands. MIDD0301 relaxed airway smooth muscle at single micromolar concentrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b93345b08045b2b3af1122f8fda4a35
https://doi.org/10.1021/acs.molpharmaceut.7b01013
https://doi.org/10.1021/acs.molpharmaceut.7b01013