Zobrazeno 1 - 10 of 103 pro vyhledávání: '"Douglas A. Spicer"'
1
Akademický článek
The Heterodimeric TWIST1-E12 Complex Drives the Oncogenic Potential of TWIST1 in Human Mammary Epithelial Cells
Autor: Laurent Jacqueroud, Charlotte Bouard, Geoffrey Richard, Léa Payen, Mojgan Devouassoux-Shisheboran, Douglas B. Spicer, Julie Caramel, Guillaume Collin, Alain Puisieux, Agnès Tissier, Stéphane Ansieau
Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 18, Iss 5, Pp 317-327 (2016)
The TWIST1 embryonic transcription factor displays biphasic functions during the course of carcinogenesis. It facilitates the escape of cells from oncogene-induced fail-safe programs (senescence, apoptosis) and their consequent neoplastic transformat
Externí odkaz: https://doaj.org/article/37d9570f42444163885d0460850f63e5
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7
Akademický článek
Twist1 controls a cell-specification switch governing cell fate decisions within the cardiac neural crest.
Autor: Joshua W Vincentz, Beth A Firulli, Andrea Lin, Douglas B Spicer, Marthe J Howard, Anthony B Firulli
Publikováno v: PLoS Genetics, Vol 9, Iss 3, p e1003405 (2013)
Neural crest cells are multipotent progenitor cells that can generate both ectodermal cell types, such as neurons, and mesodermal cell types, such as smooth muscle. The mechanisms controlling this cell fate choice are not known. The basic Helix-loop-
Externí odkaz: https://doaj.org/article/84367254c64048cc8abd24df334edc5f
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8
Making the Connection: Using Concept Mapping to Bring the Basic Sciences to the Diagnosis
Autor: Douglas B. Spicer, Sean M. Kilgallen, Kathryn H. Thompson
Publikováno v: The Journal of the American Osteopathic Association. 120(8)
Although medical education has historically emphasized the role and importance of basic science in clinical reasoning, educators have struggled to teach basic science to optimize its use for students. Concept mapping helps students develop relationsh
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47f72a4ea6899a3d23e0b881a25e2eb2
https://pubmed.ncbi.nlm.nih.gov/32717087
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9
Akademický článek
EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors in transgenic mice.
Autor: Anne-Pierre Morel, George W Hinkal, Clémence Thomas, Frédérique Fauvet, Stéphanie Courtois-Cox, Anne Wierinckx, Mojgan Devouassoux-Shisheboran, Isabelle Treilleux, Agnès Tissier, Baptiste Gras, Julie Pourchet, Isabelle Puisieux, Gareth J Browne, Douglas B Spicer, Joël Lachuer, Stéphane Ansieau, Alain Puisieux
Publikováno v: PLoS Genetics, Vol 8, Iss 5, p e1002723 (2012)
The epithelial-mesenchymal transition (EMT) is an embryonic transdifferentiation process consisting of conversion of polarized epithelial cells to motile mesenchymal ones. EMT-inducing transcription factors are aberrantly expressed in multiple tumor
Externí odkaz: https://doaj.org/article/cea742889eda4b7e8c8e6148940ce073
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10
Medical Biochemistry Without Rote Memorization: Multi-Institution Implementation and Student Perceptions of a Nationally Standardized Metabolic Map for Learning and Assessment
Autor: Tina M. Cowan, Janet E. Lindsley, Michelle S. Tong, Douglas B. Spicer, Kathryn H. Thompson, Tracy B. Fulton
Publikováno v: Med Sci Educ
Despite the growing number of patients worldwide with metabolism-related chronic diseases, medical biochemistry education is commonly perceived as focusing on recall of facts irrelevant for patient care. The authors suggest that this focus on rote me
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8674eedbb3c00b4977c7ed2729257271
https://doi.org/10.1007/s40670-018-00631-y
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