Výsledky vyhledávání - "Douglas A. Medvetz"

Akademický článek

MicroRNA-21 is induced by rapamycin in a model of tuberous sclerosis (TSC) and lymphangioleiomyomatosis (LAM).

Autor: Anil J Trindade, Douglas A Medvetz, Nicole A Neuman, Faina Myachina, Jane Yu, Carmen Priolo, Elizabeth P Henske

Publikováno v: PLoS ONE, Vol 8, Iss 3, p e60014 (2013)

Lymphangioleiomyomatosis (LAM), a multisystem disease of women, is manifest by the proliferation of smooth muscle-like cells in the lung resulting in cystic lung destruction. Women with LAM can also develop renal angiomyolipomas. LAM is caused by mut

Externí odkaz: https://doaj.org/article/ddb59a7df09540ffbfb141c1acaa6b80

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High-Throughput Drug Screen Identifies Chelerythrine as a Selective Inducer of Death in a TSC2-null Setting

Autor: Chenggang Li, Carmen Priolo, Jane J. Yu, Andrey A. Parkhitko, Damir Khabibullin, Murugabaskar Balan, Yang Sun, Soumitro Pal, Elizabeth P. Henske, Douglas A. Medvetz, John M. Asara

Publikováno v: Molecular Cancer Research. 13:50-62

Tuberous sclerosis complex (TSC) is an autosomal dominant syndrome associated with tumors of the brain, heart, kidney, and lung. The TSC protein complex inhibits the mammalian or mechanistic target of rapamycin complex 1 (mTORC1). Inhibitors of mTORC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::742736ac22ab515cbd65f003a1e2873d
https://doi.org/10.1158/1541-7786.mcr-14-0440

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Folliculin regulates cell-cell adhesion, AMPK, and mTORC1 in a cell-type-specific manner in lung-derived cells

Autor: Hayden Huang, Jane J. Yu, Venkatesh Hariharan, Rebecca M. Baron, Andrey A. Parkhitko, Chenggang Li, Miguel A. Pinilla, Erik Zhang, Douglas A. Medvetz, Maria Laucho Contreras, Elizabeth P. Henske, Anja Hergrueter, Damir Khabibullin, Caroline A. Owen

Publikováno v: Physiological Reports

Germline loss‐of‐function BHD mutations cause cystic lung disease and hereditary pneumothorax, yet little is known about the impact of BHD mutations in the lung. Folliculin (FLCN), the product of the Birt–Hogg–Dube (BHD) gene, has been linked

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::531d4f6cf6b9c09653f67f463a000005
https://pubmed.ncbi.nlm.nih.gov/25121506

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Crown ether complexes of HPCl6

Autor: Vincenzo Scionti, Matthew J. Panzner, Douglas A. Medvetz, Claire A. Tessier, Wiley J. Youngs, Chrys Wesdemiotis, Zin-Min Tun

Publikováno v: Journal of the American Chemical Society. 132(48)

The reactions of HCl, PCl5, and a crown ether (12-crown-4 or 18-crown-6) in CHCl3 under anaerobic conditions give complexes of the superacid HPCl6: [H(12-crown-4)][PCl6 ] and [H(18-crown-6)2][PCl6]. The crystal structures indicate that the proton lie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e7c24ba3f4b6fe6156cb177a8620276
https://pubmed.ncbi.nlm.nih.gov/21080621

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The antimicrobial efficacy of sustained release silver-carbene complex-loaded L-tyrosine polyphosphate nanoparticles: characterization, in vitro and in vivo studies

Autor: Wiley J. Youngs, Jane B. Taylor, Carolyn L. Cannon, Daniel S. Han, Christine E. Hovis, Julia K. Hilliard, Andrew J. Ditto, Yang H. Yun, Douglas A. Medvetz, Khadijah M. Hindi, Matthew J. Panzner

Publikováno v: Biomaterials. 30(22)

The pressing need to treat multi-drug resistant bacteria in the chronically infected lungs of cystic fibrosis (CF) patients has given rise to novel nebulized antimicrobials. We have synthesized a silver-carbene complex (SCC10) active against a variet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a23ceb27692b94e5e54d2db027f3d89a
https://pubmed.ncbi.nlm.nih.gov/19395021

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Abstract A35: Identification of pro-survival rapamycin-dependent microRNA (Rapa-miRs) in tuberous sclerosis complex

Autor: Carmen Priolo, Hilaire C. Lam, Elizabeth P. Henske, Anil J. Trindade, Jane J. Yu, Douglas A. Medvetz, Stephen Y. Chan

Publikováno v: Cancer Research. 73:A35-A35

Background: Tuberous sclerosis complex (TSC) is a multisystem, hamartomatous disease associated with tumors of the brain, skin and kidney, as well as progressive cystic lung destruction characteristic of lymphangioleiomyomatosis (LAM). TSC is caused

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b63fe2b84042ab25ecf6ce4e17bae77c
https://doi.org/10.1158/1538-7445.fbcr13-a35

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Folliculin, the Product of the Birt-Hogg-Dube Tumor Suppressor Gene, Interacts with the Adherens Junction Protein p0071 to Regulate Cell-Cell Adhesion

Autor: Elena A. Goncharova, Elizabeth P. Henske, Douglas A. Medvetz, Thomas N. Darling, Tanja Schlechter, Damir Khabibullin, Vera P. Krymskaya, Ilse Hofmann, Venkatesh Hariharan, Hayden Huang, James K. Liao, Pat P. Ongusaha

Publikováno v: PLoS ONE
PLoS ONE, Vol 7, Iss 11, p e47842 (2012)

Birt-Hogg-Dube (BHD) is a tumor suppressor gene syndrome associated with fibrofolliculomas, cystic lung disease, and chromophobe renal cell carcinoma. In seeking to elucidate the pathogenesis of BHD, we discovered a physical interaction between folli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f96dd2fc7bd044adab044bef5e56a4b2
https://doi.org/10.1371/journal.pone.0047842

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Shape-persistent, ruthenium(ii)- and iron(ii)-bisterpyridine metallodendrimers: synthesis, traveling-wave ion-mobility mass spectrometry, and photophysical properties

Autor: Jin-Liang Wang, Chrys Wesdemiotis, Xiaopeng Li, George R. Newkome, Charles N. Moorefield, Frank R. Fronczek, Carol D. Shreiner, Sreedhar R. Tummalapalli, Douglas A. Medvetz, Matthew J. Panzner, Xiaocun Lu

Publikováno v: New Journal of Chemistry. 36:484

A class of shape-persistent metallodendrimer has been developed through a self-assembly strategy, in which 〈tpy-RuII-tpy〉 or 〈tpy-FeII-tpy〉 connectivity is utilized, as branching moieties or nodes. These metallomacromolecules were fully chara

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c555842ddb63356542d3d7143c32ac3
https://doi.org/10.1039/c2nj20799k

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