Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Douglas A. Marsteller"'
Autor:
Mary Ann Mascelli, Matthew W Hruska, Sam Liao, Lori Liao, Patrick Davies, Jennifer Kong, Douglas A Marsteller
Purpose To characterize the pharmacokinetics (PK) of naloxegol in paediatric subjects (≥ 6 months to Methods Subjects in three age groups (≥12 to Results Naloxegol exhibits comparable PK characteristics in paediatric and adult subjects. Neither a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1af194453aa00bdf73d36922114faf7c
https://doi.org/10.21203/rs.3.rs-2612997/v1
https://doi.org/10.21203/rs.3.rs-2612997/v1
Autor:
Lisa Hickey, J. Christian Virchow, Guy Brusselle, Jonathan A. Bernstein, Jorge Maspero, Douglas A Marsteller, Joshua J. Jacobs, Mario Castro, Jennifer McElhattan, Yochai Adir, Kevin R. Murphy, Rebecca Vanlandingham, Margaret Garin, Marc Humbert
Publikováno v:
The Lancet Respiratory Medicine, 8(5), 461-474. Elsevier Ltd.
Reslizumab 3 mg/kg administered intravenously is approved for the treatment of severe eosinophilic asthma. We assessed the safety and efficacy of subcutaneous reslizumab 110 mg in two trials in patients with uncontrolled severe asthma and increased b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe833c861055e73c527448191ad6427b
https://pubmed.ncbi.nlm.nih.gov/32066536
https://pubmed.ncbi.nlm.nih.gov/32066536
Autor:
Jeffrey S. Barrett, Douglas A. Marsteller, Richard W. Foltin, B. Timothy Walsh, Michael M. Myers, Nicole C. Barbarich-Marsteller, Mark D. Underwood
Publikováno v:
International Journal of Eating Disorders. 46:737-746
Objective Activity-based anorexia is a translational rodent model that results in severe weight loss, hyperactivity, and voluntary self-starvation. The goal of our investigation was to identify vulnerable and resistant phenotypes of activity-based an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a2a0a6b99d8960423f254912f7c8b05
https://doi.org/10.1002/eat.22149
https://doi.org/10.1002/eat.22149
Autor:
John K. Robinson, Iordanis Gravanis, Stella E. Tsirka, Stephen L. Dewey, Douglas A. Marsteller, Konstantinos Pothakos
Publikováno v:
Brain Research. 1326:135-142
Tissue Plasminogen Activator (tPA) is a serine protease expressed in different areas of the mammalian brain. It has been used clinically to dissolve clots and shown to have a role in neurodegeneration. Early studies suggested that tPA plays an import
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::747809f98cf210dc44eac09de32cf696
https://doi.org/10.1016/j.brainres.2009.12.095
https://doi.org/10.1016/j.brainres.2009.12.095
Autor:
Laxminarayan G. Hegde, Mary W. Walker, Vrej Jubian, Mariusz Papp, Mohammad R. Marzabadi, Douglas A. Craig, Christophe P. G. Gerald, David H. Overstreet, Silke Miller, Gamini Chandrasena, Huailing Zhong, Toni D. Wolinsky, Douglas A. Marsteller, Xinyan Huang
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 328:900-911
Neuropeptide Y (NPY) regulates physiological processes via receptor subtypes (Y1, Y2, Y4, Y5, and y6). The Y5 receptor is well known for its role in appetite. Based on expression in the limbic system, we hypothesized that the Y5 receptor might also m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::152b8da161e9f077a50457dd9cc641dc
https://doi.org/10.1124/jpet.108.144634
https://doi.org/10.1124/jpet.108.144634
Publikováno v:
Psychopharmacology. 168:339-343
gamma-Vinyl GABA (GVG) irreversibly inhibits GABA-transaminase. This non-receptor mediated inhibition requires de novo synthesis for restoration of functional GABA catabolism.Given its preclinical success for treating substance abuse and the increase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7a2a7b0a1ecede9d69713466bb11b3c
https://doi.org/10.1007/s00213-003-1446-6
https://doi.org/10.1007/s00213-003-1446-6
Autor:
Charles R. Ashby, Samuel J. Gatley, Andrew N. Gifford, Madina R. Gerasimov, Stephen L. Dewey, Wynne K. Schiffer, Pauline Carter, David Alexoff, Stephen A. Vitkun, Colleen Shea, Payton King, Victor Garza, Douglas A. Marsteller, Jean Logan, Richard A. Ferrieri
Publikováno v:
Life Sciences. 70:2811-2828
Inhalant abuse is a rapidly growing health problem particularly among adolescents. Yet we know little about the neural mechanisms underlying the abuse liability of inhalants, particularly when compared to other addictive drugs. Specifically, our unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11f8338f2f2b426fa904addad15ed054
https://doi.org/10.1016/s0024-3205(02)01542-4
https://doi.org/10.1016/s0024-3205(02)01542-4
Autor:
Madina R. Gerasimov, Wynne K. Schiffer, Stephen L. Dewey, Charles R. Ashby, Lauren Hofmann, David Alexoff, Douglas A. Marsteller, Jonathan D. Brodie
Publikováno v:
Neuropsychopharmacology. 25:704-712
To explore the role of endogenous GABA in NMDA antagonist induced dopamine (DA) release, we used in vivo microdialysis to study the effects of pretreatment with gamma-vinyl GABA (GVG) on phencyclidine (PCP)-induced DA release in terminal regions of m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::102412866b94b5a165e8e1fa4ee2d872
https://doi.org/10.1016/s0893-133x(01)00268-8
https://doi.org/10.1016/s0893-133x(01)00268-8
Autor:
Mary W, Walker, Toni D, Wolinsky, Vrej, Jubian, Gamini, Chandrasena, Huailing, Zhong, Xinyan, Huang, Silke, Miller, Laxminarayan G, Hegde, Douglas A, Marsteller, Mohammad R, Marzabadi, Mariusz, Papp, David H, Overstreet, Christophe P G, Gerald, Douglas A, Craig
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 328(3)
Neuropeptide Y (NPY) regulates physiological processes via receptor subtypes (Y(1), Y(2), Y(4), Y(5), and y(6)). The Y(5) receptor is well known for its role in appetite. Based on expression in the limbic system, we hypothesized that the Y(5) recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bfa69ad7a4e42927a9fa0893ce2c8929
https://pubmed.ncbi.nlm.nih.gov/19098165
https://pubmed.ncbi.nlm.nih.gov/19098165
Autor:
Christophe P.G. Gerald, Chad J. Swanson, Ron Kong, Douglas A. Craig, Douglas A. Marsteller, Manuel Cajina
Publikováno v:
European journal of pharmacology. 602(1)
Antidepressant treatment of two or more weeks in rats has been shown to enhance the locomotor-stimulating effects of dopamine D 2 /D 3 receptor agonists. This action has been attributed to an increased sensitivity of postsynaptic dopamine receptors i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5caf28b4be0809b192f0bebfc189eb2b
https://pubmed.ncbi.nlm.nih.gov/19027732
https://pubmed.ncbi.nlm.nih.gov/19027732