Gene transcription changes in asthmatic chronic rhinosinusitis with nasal polyps and comparison to those in atopic dermatitis.

Autor: Douglas A Plager, Jane C Kahl, Yan W Asmann, Allan E Nilson, John F Pallanch, Oren Friedman, Hirohito Kita

Publikováno v: PLoS ONE, Vol 5, Iss 7, p e11450 (2010)

BACKGROUND:Asthmatic chronic rhinosinusitis with nasal polyps (aCRSwNP) is a common disruptive eosinophilic disease without effective medical treatment. Therefore, we sought to identify gene expression changes, particularly those occurring early, in

Externí odkaz: https://doaj.org/article/9e755a8f7a444834bf0cc24f4017693a

Pimecrolimus Reduces Eosinophil Activation Associated with Calcium Mobilization

Autor: Yoshinori Matsuwaki, Arvind Madaan, Hirohito Kita, Susan A. Henke, Diane L. Squillace, Ross A. Dierkhising, Douglas A. Plager

Publikováno v: International Archives of Allergy and Immunology. 149:119-126

Background: Pimecrolimus is a calcineurin inhibitor that inhibits T cell and mast cell activation and effectively treats atopic dermatitis. However, its effects on eosinophils, a cell type implicated in allergic disease pathology, are unknown. Theref

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65bd8d04245bbc390048368a73c0b033
https://doi.org/10.1159/000189194

Contributors

Autor: Seema S. Aceves, Ian M. Adcock, N. Franklin Adkinson, Cezmi A. Akdis, Mübeccel Akdis, Keith C. Allen, Andrea J. Apter, Claus Bachert, Katherine J. Baines, Mark Ballow, Peter J. Barnes, Neal P. Barney, Fuad M. Baroody, Heidrun Behrendt, Bruce G. Bender, M. Cecilia Berin, Paul J. Bertics, Thomas Bieber, Leonard Bielory, Judith Black, Bruce S. Bochner, Mark Boguniewicz, Larry Borish, Louis-Philippe Boulet, Jean Bousquet, Joshua A. Boyce, Peter Bradding, Christopher E. Brightling, David H. Broide, Simon G.A. Brown, Rebecca H. Buckley, Janette K. Burgess, A. Wesley Burks, Peter G.J. Burney, Robert K. Bush, William W. Busse, Jeroen Buters, Lien Calus, Carlos A. Camargo, Brendan J. Canning, Thomas B. Casale, Mario Castro, Gülfem E. Çelik, Christina Chambers, Javier Chinen, Anca Mirela Chiriac, Sandra C. Christiansen, Kian Fan Chung, Donald W. Cockcroft, Lauren Cohn, Ellen B. Cook, Jonathan Corren, Adnan Custovic, Pascal Demoly, Dhananjay Desai, Graham Devereux, Thomas Diepgen, Myrna B. Dolovich, David A. Dorward, Jo A. Douglass, Stephen R. Durham, Sandy R. Durrani, Mark S. Dykewicz, Ronald Eccles, Alan M. Edwards, Renata J.M. Engler, Robert E. Esch, Sean B. Fain, Reuben Falkoff, Matthew J. Fenton, Thomas A. Fleisher, Joseph R. Fontana, Michael M. Frank, Anthony J. Frew, Glenn T. Furuta, Holger Garn, Monica L. Gavala, Philippe Gevaert, Viviane Ghanim, Peter G. Gibson, David B.K. Golden, Matthew J. Greenhawt, Anete S. Grumach, Theresa W. Guilbert, Sudhir Gupta, Andrew J. Halayko, Teal S. Hallstrand, Robert G. Hamilton, Hamida Hammad, Trevor T. Hansel, Catherine Hawrylowicz, Michelle L. Hernandez, C. Garren Hester, Jeremy Hirota, Stephen T. Holgate, John W. Holloway, Charles G. Irvin, Richard S. Irwin, Elliot Israel, Daniel J. Jackson, Peter K. Jeffery, Diane F. Jelinek, Richard B. Johnston, Stacie M. Jones, H. William Kelly, John M. Kelso, Stephen F. Kemp, Hirohito Kita, Amy D. Klion, Darryl Knight, Marek L. Kowalski, Cynthia J. Koziol-White, Rakesh K. Kumar, Gideon Lack, Bart N. Lambrecht, Beth L. Laube, Heather K. Lehman, Robert F. Lemanske, Catherine Lemière, Donald Y.M. Leung, Ian P. Lewkowich, James T. Li, Xiu-Min Li, Phillip L. Lieberman, Andrew H. Liu, Clare Lloyd, Christopher D. Lucas, Andrew D. Luster, Eric Macy, J. Mark Madison, Elizabeth C. Matsui, Michael H. Mellon, Dean D. Metcalfe, Zamaneh Mikhak, E.N. Clare Mills, Harold S. Nelson, Sarah K. Nicholas, Rosemary L. Nixon, Anna Nowak-We˛grzyn, Paul M. O'Byrne, Hans C. Oettgen, Robyn E. O'Hehir, Brian G. Oliver, Jordan S. Orange, Dennis R. Ownby, C.P. Page, Reynold A. Panettieri, Hae-Sim Park, Mary E. Paul, Ian D. Pavord, Ruby Pawankar, David B. Peden, R. Stokes Peebles, Stephen P. Peters, Werner J. Pichler, Mark R. Pittelkow, Douglas A. Plager, Thomas A.E. Platts-Mills, Susan L. Prescott, Benjamin A. Raby, Hengameh H. Raissy, Cynthia S. Rand, Anuradha Ray, Harald Renz, Jonathan P. Richardson, Johannes Ring, Clive Robinson, Duncan F. Rogers, Lanny J. Rosenwasser, Adriano G. Rossi, Marc E. Rothenberg, Brian H. Rowe, Sejal Saglani, Sarbjit S. Saini, Hirohisa Saito, Hugh A. Sampson, Mario Sanchez-Borges, Alessandra Sandrini, Guy W. Scadding, Michael Schatz, John T. Schroeder, Malcolm R. Sears, Christine Seroogy, William T. Shearer, James H. Shelhamer, Scott H. Sicherer, F. Estelle R. Simons, Jodie L. Simpson, Jay E. Slater, Peter D. Sly, Philip H. Smith, Michael C. Sneller, Domenico Spina, P. Sriramarao, James L. Stahl, John W. Steinke, Geoffrey A. Stewart, Jeffrey R. Stokes, Kathleen E. Sullivan, Steve L. Taylor, Abba I. Terr, Euan Tovey, Thai Tran, Bradley J. Undem, Peter Valent, Olivier Vandenplas, Stephan von Gunten, Richard W. Weber, Peter F. Weller, Sally E. Wenzel, Gregory J. Wiepz, Marsha Wills-Karp, Robert A. Wood, Leman Yel, Robert S. Zeiger, Jihui Zhang, Bruce L. Zuraw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8dc83bd7dc6bd70bbbb82e6ff0915481
https://doi.org/10.1016/b978-0-323-08593-9.00110-8

A novel human homolog of eosinophil major basic protein

Autor: Gerald J. Gleich, Cheryl R. Adolphson, Douglas A. Plager

Publikováno v: Immunological Reviews. 179:192-202

Summary: Eosinophil major basic protein (MBP) contributes to host defense and disease pathophysiology. Chromosome 11 contains the genes for human MBP1 (hMBP1) and a second novel MBP, hMBP2, in the centromere to 11q12 region. Interestingly, greater si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6a61c65a2c06a496ff8139af3017de6
https://doi.org/10.1034/j.1600-065x.2001.790119.x

Gene transcription abnormalities in canine atopic dermatitis and related human eosinophilic allergic diseases

Autor: Sandra N. Koch, Sheila M. F. Torres, Douglas A. Plager, Hirohito Kita

Publikováno v: Veterinary immunology and immunopathology. 149(1-2)

Canine atopic dermatitis (AD) is clinically similar to human AD, implicating it as a useful model of human eosinophilic allergic disease. To identify cutaneous gene transcription changes in relatively early inflammation of canine AD, microarrays were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aaa8da55ffbf050392e2aae46615eb3
https://pubmed.ncbi.nlm.nih.gov/22749291