Zobrazeno 1 - 10
of 369
pro vyhledávání: '"Douglas A Mitchell"'
Autor:
Dipti D Nayak, Andi Liu, Neha Agrawal, Roy Rodriguez-Carerro, Shi-Hui Dong, Douglas A Mitchell, Satish K Nair, William W Metcalf
Publikováno v:
PLoS Biology, Vol 18, Iss 2, p e3000507 (2020)
The enzyme methyl-coenzyme M reductase (MCR) plays an important role in mediating global levels of methane by catalyzing a reversible reaction that leads to the production or consumption of this potent greenhouse gas in methanogenic and methanotrophi
Externí odkaz:
https://doaj.org/article/c5e074b9ed204ef29e0c3b33b2436ccb
Publikováno v:
eLife, Vol 6 (2017)
Methyl-coenzyme M reductase (MCR), found in strictly anaerobic methanogenic and methanotrophic archaea, catalyzes the reversible production and consumption of the potent greenhouse gas methane. The α subunit of MCR (McrA) contains several unusual po
Externí odkaz:
https://doaj.org/article/f26843d3270441ea9267ec95e1747d0b
Autor:
Dinh T. Nguyen, Lingyang Zhu, Danielle L. Gray, Toby J. Woods, Chandrashekhar Padhi, Kristen M. Flatt, Douglas A. Mitchell, Wilfred A. van der Donk
Publikováno v:
ACS Central Science, Vol 10, Iss 5, Pp 1022-1032 (2024)
Externí odkaz:
https://doaj.org/article/863a59fb381046c2bfa098527855dc53
Autor:
Hengqian Ren, Shravan R. Dommaraju, Chunshuai Huang, Haiyang Cui, Yuwei Pan, Marko Nesic, Lingyang Zhu, David Sarlah, Douglas A. Mitchell, Huimin Zhao
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
RiPP discovery has expanded the scope of post-translational modification chemistry, but genome mining of RiPP classes remains an unsolved challenge. Here, the authors employed bioinformatics and synthetic biology approaches to discover and characteri
Externí odkaz:
https://doaj.org/article/f15bf7302e00471cbf0da1d6ede8a7ee
Autor:
Mark C. Walker, Sara M. Eslami, Kenton J. Hetrick, Sarah E. Ackenhusen, Douglas A. Mitchell, Wilfred A. van der Donk
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-17 (2020)
Abstract Background Lanthipeptides belong to the ribosomally synthesized and post-translationally modified peptide group of natural products and have a variety of biological activities ranging from antibiotics to antinociceptives. These peptides are
Externí odkaz:
https://doaj.org/article/decd7fc7c6884972953490f52a0a8638
Autor:
Ashley M. Kretsch, Mayuresh G. Gadgil, Adam J. DiCaprio, Susanna E. Barrett, Bryce L. Kille, Yuanyuan Si, Lingyang Zhu, Douglas A. Mitchell
Publikováno v:
Biochemistry
The RiPP precursor Recognition Element (RRE) is a conserved domain found in many prokaryotic ribosomally synthesized and post-translationally modified peptide (RiPP) biosynthetic gene clusters (BGCs). RREs bind with high specificity and affinity to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed782c606eae86b30c65411d93e39ca4
https://doi.org/10.1021/acs.biochem.2c00700
https://doi.org/10.1021/acs.biochem.2c00700
Autor:
Brandon J. Burkhart, Nidhi Kakkar, Graham A. Hudson, Wilfred A. van der Donk, Douglas A. Mitchell
Publikováno v:
ACS Central Science, Vol 3, Iss 6, Pp 629-638 (2017)
Externí odkaz:
https://doaj.org/article/016abb2db56b48568e2788557924e1a9
Autor:
Dinh T. Nguyen, Tung T. Le, Andrew J. Rice, Graham A. Hudson, Wilfred A. van der Donk, Douglas A. Mitchell
Publikováno v:
Journal of the American Chemical Society. 144:11263-11269
Macrocyclic peptides are sought-after molecular scaffolds for drug discovery, and new methods to access diverse libraries are of increasing interest. Here, we report the enzymatic synthesis of pyridine-based macrocyclic peptides (pyritides) from line
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cbe3bcd6ae62dba70a15bfb0caa3358
https://doi.org/10.1021/jacs.2c02824
https://doi.org/10.1021/jacs.2c02824
Autor:
Timothy W. Precord, Sangeetha Ramesh, Shravan R. Dommaraju, Lonnie A. Harris, Bryce L. Kille, Douglas A. Mitchell
Publikováno v:
ACS Bio & Med Chem Au.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac78013cef4306461a372823c68a7237
https://doi.org/10.1021/acsbiomedchemau.2c00085
https://doi.org/10.1021/acsbiomedchemau.2c00085
Publikováno v:
ACS Bio Med Chem Au
ACS Bio & Med Chem Au, Vol 2, Iss 1, Pp 22-35 (2021)
ACS Bio & Med Chem Au, Vol 2, Iss 1, Pp 22-35 (2021)
The radical SAM superfamily (RSS), arguably the most functionally diverse enzyme superfamily, is also one of the largest with ~700K members currently in the UniProt database. The vast majority of the members have uncharacterized enzymatic activities
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3bb47ceb787926e1ed496babb5e5fe3
https://pubmed.ncbi.nlm.nih.gov/36119373
https://pubmed.ncbi.nlm.nih.gov/36119373