Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Douglas A Kuntz"'
Autor:
Mark F. Mabanglo, Brian Wilson, Mahmoud Noureldin, Serah W. Kimani, Ahmed Mamai, Chiara Krausser, Héctor González-Álvarez, Smriti Srivastava, Mohammed Mohammed, Laurent Hoffer, Manuel Chan, Jamie Avrumutsoae, Alice Shi Ming Li, Taraneh Hajian, Sarah Tucker, Stuart Green, Magdalena Szewczyk, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar, Suzanne Ackloo, Peter Loppnau, Yanjun Li, Almagul Seitova, Taira Kiyota, Jue George Wang, Gilbert G. Privé, Douglas A. Kuntz, Bhashant Patel, Vaibhavi Rathod, Anand Vala, Bhimsen Rout, Ahmed Aman, Gennady Poda, David Uehling, Jailall Ramnauth, Levon Halabelian, Richard Marcellus, Rima Al-awar, Masoud Vedadi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Proteolysis-targeting chimeras (PROTACs) have been explored for the degradation of drug targets for more than two decades. However, only a handful of E3 ligase substrate receptors have been efficiently used. Downregulation and mutation of th
Externí odkaz:
https://doaj.org/article/3472b510aaa44f048ba5f7afe215f30a
Autor:
Michael R Marit, Manprit Chohan, Natasha Matthew, Kai Huang, Douglas A Kuntz, David R Rose, Dwayne L Barber
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43437 (2012)
The non-receptor tyrosine kinase JAK2 is implicated in a group of myeloproliferative neoplasms including polycythemia vera, essential thrombocythemia, and primary myelofibrosis. JAK2-selective inhibitors are currently being evaluated in clinical tria
Externí odkaz:
https://doaj.org/article/71edbe4ec5af46f3bd7c1c259ac9a289
Autor:
Teklab Gebregiworgis, Jonathan Yui-Lai Chan, Douglas A. Kuntz, Gilbert G. Privé, Christopher B. Marshall, Mitsuhiko Ikura
Publikováno v:
European Journal of Cell Biology, Vol 103, Iss 2, Pp 151414- (2024)
The RAS isoforms (KRAS, HRAS and NRAS) have distinct cancer type-specific profiles. NRAS mutations are the second most prevalent RAS mutations in skin and hematological malignancies. Although RAS proteins were considered undruggable for decades, isof
Externí odkaz:
https://doaj.org/article/3a8df14dd4c348f6b90cd509a98b511e
Autor:
Ahmed Mamai, Anh M. Chau, Brian J. Wilson, Iain D. Watson, Babu B. Joseph, Pandiaraju R. Subramanian, Monzur M. Morshed, Justin A. Morin, Michael A. Prakesch, Tianbao Lu, Pete Connolly, Douglas A. Kuntz, Neil C. Pomroy, Gennady Poda, Kong Nguyen, Richard Marcellus, Graig Strathdee, Brigitte Theriault, Ratheesh Subramaniam, Mohammed Mohammed, Ayome Abibi, Manuel Chan, Jeffrey Winston, Taira Kiyota, Elijus Undzys, Ahmed Aman, Nigel Austin, Marc Du Jardin, Kathryn Packman, Ulrike Phillippar, Riccardo Attar, James Edwards, Jeff O’Meara, David E. Uehling, Rima Al-awar, Gilbert G. Privé, Methvin B. Isaac
Publikováno v:
ACS Medicinal Chemistry Letters. 14:199-210
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7baafefe694004e06c601f99ee7e496
https://doi.org/10.1021/acsmedchemlett.2c00502
https://doi.org/10.1021/acsmedchemlett.2c00502
Autor:
Yuan Gao, Douglas A. Kuntz, Dongxin Ma, Mikhail Askerka, Andrew Johnston, Gilbert G. Privé, Edward H. Sargent, Petar Todorović, Jeffrey Kirman
Publikováno v:
Matter. 2:938-947
Summary Perovskites have seen significant research interest in the last decade. As ternary and quaternary compounds, their chemical space is exceptionally large, yet perovskite development has been limited to a restricted set of chemical constituents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f90636bdfd0ed2e816bf51cb366ec723
https://doi.org/10.1016/j.matt.2020.02.012
https://doi.org/10.1016/j.matt.2020.02.012
Autor:
Husna Anwar, Andrew Johnston, Suhas Mahesh, Kamalpreet Singh, Zhibo Wang, Douglas A. Kuntz, Isaac Tamblyn, Oleksandr Voznyy, Gilbert G. Privé, Edward H. Sargent
Publikováno v:
ACS central science. 8(5)
High-throughput experimentation (HTE) seeks to accelerate the exploration of materials space by uniting robotics, combinatorial methods, and parallel processing. HTE is particularly relevant to metal halide perovskites (MHPs), a diverse class of opto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e377ea894cb23fcb71ae75e57145b1f
https://pubmed.ncbi.nlm.nih.gov/35647281
https://pubmed.ncbi.nlm.nih.gov/35647281
Autor:
Ben J, Eves, Teklab, Gebregiworgis, Geneviève M C, Gasmi-Seabrook, Douglas A, Kuntz, Gilbert G, Privé, Christopher B, Marshall, Mitsuhiko, Ikura
Publikováno v:
Journal of Molecular Biology. 434:167527
Ral Guanine Nucleotide Dissociation Stimulator Like 1 (RGL1) is a RAS effector protein that activates Ral GTPase by stimulating nucleotide exchange. Most structures of RAS-effector complexes are for the HRAS isoform; relatively few KRAS-effector stru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::049303c8369f9b2d22ab65b8f3c7eeca
https://doi.org/10.1016/j.jmb.2022.167527
https://doi.org/10.1016/j.jmb.2022.167527
Autor:
Tristan M G Kenney, Douglas A. Kuntz, Luke Whitesell, Paul T Marcyk, Alice Xue, Gilbert G. Privé, Emmanuelle V. LeBlanc, Noelle S. Williams, Lauren E. Brown, Stephen Bengtson, David S. Huang, Leah E. Cowen, Richard Trilles, Francisco Ortiz, Nicole Robbins, Damian J. Krysan
Publikováno v:
J Med Chem
The essential eukaryotic chaperone Hsp90 regulates the form and function of diverse client proteins, many of which govern thermotolerance, virulence, and drug resistance in fungal species. However, use of Hsp90 inhibitors as antifungal therapeutics h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51437590f15295e1392ea1f21207b793
https://pubmed.ncbi.nlm.nih.gov/33444025
https://pubmed.ncbi.nlm.nih.gov/33444025
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 74:a405-a405
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b23c0ab2dbd453eb9cd969828dc83890
https://doi.org/10.1107/s0108767318095958
https://doi.org/10.1107/s0108767318095958
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:2829-2835
The syntheses of an isomer of kotalanol, a naturally occurring glucosidase inhibitor, and of kotalanol itself are described. The target compounds were synthesized by nucleophilic attack of PMB-protected 1,4-anhydro-4-thio- d -arabinitol at the least
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c2f46a1874bf3337b34a7a9d78f51b
https://doi.org/10.1016/j.bmc.2010.03.027
https://doi.org/10.1016/j.bmc.2010.03.027