Zobrazeno 1 - 10
of 241
pro vyhledávání: '"Douglas A Gray"'
Autor:
Katherine V Clark-Knowles, Xiaohong He, Karen Jardine, Josée Coulombe, Danielle Dewar-Darch, Annabelle Z Caron, Douglas A Gray, Michael W McBurney
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173002 (2017)
The SIRT1 protein deacetylase is reported to have a remarkably wide spectrum of biological functions affecting such varied processes as aging, cancer, metabolism, neurodegeneration and immunity. However, the SIRT1 literature is also full of contradic
Externí odkaz:
https://doaj.org/article/eea5c16680974a76a38d73f40805ccdc
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73631 (2013)
Progress in the development of therapeutic interventions to treat or slow the progression of Alzheimer's disease has been hampered by lack of efficacy and unforeseen side effects in human clinical trials. This setback highlights the need for new appr
Externí odkaz:
https://doaj.org/article/8caadb27d5ab41cb97fdeff47d23c4c2
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 9 (2010)
Expanded polyglutamine (polyQ) proteins are known to be the causative agents of a number of human neurodegenerative diseases but the molecular basis of their cytoxicity is still poorly understood. PolyQ tracts may impede the activity of the proteasom
Externí odkaz:
https://doaj.org/article/5199f506c9a84b09a689c68127b84375
Publikováno v:
PLoS ONE, Vol 3, Iss 5, p e2130 (2008)
The signaling pathways that may modulate the pathogenesis of diseases induced by expanded polyglutamine proteins are not well understood.Herein we demonstrate that expanded polyglutamine protein cytotoxicity is mediated primarily through activation o
Externí odkaz:
https://doaj.org/article/ad94c4a9d94048d2bce1d708c0b8826b
Autor:
Roland K Chiu, Jan Brun, Chantal Ramaekers, Jan Theys, Lin Weng, Philippe Lambin, Douglas A Gray, Bradly G Wouters
Publikováno v:
PLoS Genetics, Vol 2, Iss 7, p e116 (2006)
Eukaryotic cells possess several mechanisms to protect the integrity of their DNA against damage. These include cell-cycle checkpoints, DNA-repair pathways, and also a distinct DNA damage-tolerance system that allows recovery of replication forks blo
Externí odkaz:
https://doaj.org/article/a679c8b2bd1c4debbb8b9f12ed02ea33
Autor:
Victoria Allen, Josée Coulombe, Huijun Zhao, Lauren M. Kreps, David P. Cook, Benjamin Pryce, Mark Clemons, Barbara C. Vanderhyden, Douglas A. Gray, Christina L. Addison
Publikováno v:
British Journal of Cancer. 127:56-68
Background Invasive lobular carcinoma (ILC) is the second most common type of breast cancer. As few tools exist to study ILC metastasis, we isolated ILC cells with increased invasive properties to establish a spontaneously metastasising xenograft mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aab56f45f3ac64df7e81a9611f579a07
https://doi.org/10.1038/s41416-022-01778-7
https://doi.org/10.1038/s41416-022-01778-7
Autor:
Barbara C. Vanderhyden, Mary K. Senterman, Dominique Trudel, Bryan Lo, Sangeeta Murugkar, Robert W. Boyd, Douglas A. Gray, Katey J. Rayner, Jeremy Upham, Amanda Forsyth, Christian H. Allen, Feryel Azzi, Brendan S. Kelly, David P. Cook, Curtis W. McCloskey
Non-significant alteration in the immune and stromal landscape of the ovarian cortex with metformin use.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71934fdf63ce0801227f709be0558404
https://doi.org/10.1158/1078-0432.22474446
https://doi.org/10.1158/1078-0432.22474446
Autor:
Barbara C. Vanderhyden, Mary K. Senterman, Dominique Trudel, Bryan Lo, Sangeeta Murugkar, Robert W. Boyd, Douglas A. Gray, Katey J. Rayner, Jeremy Upham, Amanda Forsyth, Christian H. Allen, Feryel Azzi, Brendan S. Kelly, David P. Cook, Curtis W. McCloskey
Supplementary Data File S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02ceba622152fa0b19f5f992d0c46504
https://doi.org/10.1158/1078-0432.22474443.v1
https://doi.org/10.1158/1078-0432.22474443.v1
Autor:
Barbara C. Vanderhyden, Mary K. Senterman, Dominique Trudel, Bryan Lo, Sangeeta Murugkar, Robert W. Boyd, Douglas A. Gray, Katey J. Rayner, Jeremy Upham, Amanda Forsyth, Christian H. Allen, Feryel Azzi, Brendan S. Kelly, David P. Cook, Curtis W. McCloskey
Supplementary Legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00a2aee711b884010750b86ea2980f89
https://doi.org/10.1158/1078-0432.22474437
https://doi.org/10.1158/1078-0432.22474437
Autor:
Barbara C. Vanderhyden, Mary K. Senterman, Dominique Trudel, Bryan Lo, Sangeeta Murugkar, Robert W. Boyd, Douglas A. Gray, Katey J. Rayner, Jeremy Upham, Amanda Forsyth, Christian H. Allen, Feryel Azzi, Brendan S. Kelly, David P. Cook, Curtis W. McCloskey
Purpose:The ovarian cancer risk factors of age and ovulation are curious because ovarian cancer incidence increases in postmenopausal women, long after ovulations have ceased. To determine how age and ovulation underlie ovarian cancer risk, we assess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5940c935ec37ba9ba41a77e7ff2dce1
https://doi.org/10.1158/1078-0432.c.6528786.v1
https://doi.org/10.1158/1078-0432.c.6528786.v1