Výsledky vyhledávání - "Douglas A Gray"

Akademický článek

Reversible modulation of SIRT1 activity in a mouse strain.

Autor: Katherine V Clark-Knowles, Xiaohong He, Karen Jardine, Josée Coulombe, Danielle Dewar-Darch, Annabelle Z Caron, Douglas A Gray, Michael W McBurney

Publikováno v: PLoS ONE, Vol 12, Iss 3, p e0173002 (2017)

The SIRT1 protein deacetylase is reported to have a remarkably wide spectrum of biological functions affecting such varied processes as aging, cancer, metabolism, neurodegeneration and immunity. However, the SIRT1 literature is also full of contradic

Externí odkaz: https://doaj.org/article/eea5c16680974a76a38d73f40805ccdc

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Akademický článek

Investigating interventions in Alzheimer's disease with computer simulation models.

Autor: Carole J Proctor, Delphine Boche, Douglas A Gray, James A R Nicoll

Publikováno v: PLoS ONE, Vol 8, Iss 9, p e73631 (2013)

Progress in the development of therapeutic interventions to treat or slow the progression of Alzheimer's disease has been hampered by lack of efficacy and unforeseen side effects in human clinical trials. This setback highlights the need for new appr

Externí odkaz: https://doaj.org/article/8caadb27d5ab41cb97fdeff47d23c4c2

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Akademický článek

Experimental and computational analysis of polyglutamine-mediated cytotoxicity.

Autor: Matthew Y Tang, Carole J Proctor, John Woulfe, Douglas A Gray

Publikováno v: PLoS Computational Biology, Vol 6, Iss 9 (2010)

Expanded polyglutamine (polyQ) proteins are known to be the causative agents of a number of human neurodegenerative diseases but the molecular basis of their cytoxicity is still poorly understood. PolyQ tracts may impede the activity of the proteasom

Externí odkaz: https://doaj.org/article/5199f506c9a84b09a689c68127b84375

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Akademický článek

Activation of p38MAPK contributes to expanded polyglutamine-induced cytotoxicity.

Autor: Maria Tsirigotis, R Mitchell Baldwin, Matthew Y Tang, Ian A J Lorimer, Douglas A Gray

Publikováno v: PLoS ONE, Vol 3, Iss 5, p e2130 (2008)

The signaling pathways that may modulate the pathogenesis of diseases induced by expanded polyglutamine proteins are not well understood.Herein we demonstrate that expanded polyglutamine protein cytotoxicity is mediated primarily through activation o

Externí odkaz: https://doaj.org/article/ad94c4a9d94048d2bce1d708c0b8826b

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Akademický článek

Lysine 63-polyubiquitination guards against translesion synthesis-induced mutations.

Autor: Roland K Chiu, Jan Brun, Chantal Ramaekers, Jan Theys, Lin Weng, Philippe Lambin, Douglas A Gray, Bradly G Wouters

Publikováno v: PLoS Genetics, Vol 2, Iss 7, p e116 (2006)

Eukaryotic cells possess several mechanisms to protect the integrity of their DNA against damage. These include cell-cycle checkpoints, DNA-repair pathways, and also a distinct DNA damage-tolerance system that allows recovery of replication forks blo

Externí odkaz: https://doaj.org/article/a679c8b2bd1c4debbb8b9f12ed02ea33

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