Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Douglas A, Keller"'
Autor:
Douglas A. Keller, Arianna Bassan, Alexander Amberg, Leigh Ann Burns Naas, Jon Chambers, Kevin Cross, Frances Hall, Gloria D. Jahnke, Amarjit Luniwal, Serena Manganelli, Jordi Mestres, Amy L. Mihalchik-Burhans, David Woolley, Raymond R. Tice
Publikováno v:
Frontiers in Toxicology, Vol 5 (2023)
In silico toxicology protocols are meant to support computationally-based assessments using principles that ensure that results can be generated, recorded, communicated, archived, and then evaluated in a uniform, consistent, and reproducible manner.
Externí odkaz:
https://doaj.org/article/662e50fa83754807891531c6e030ecd7
Autor:
Bruce A. Corliss, Leon J. Delalio, T. C. Stevenson Keller, Alexander S. Keller, Douglas A. Keller, Bruce H. Corliss, Jody M. Beers, Shayn M. Peirce, Brant E. Isakson
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Frigid temperatures of the Southern Ocean are known to be an evolutionary driver in Antarctic fish. For example, many fish have reduced red blood cell (RBC) concentration to minimize vascular resistance. Via the oxygen-carrying protein hemoglobin, RB
Externí odkaz:
https://doaj.org/article/c29f96a691244be9b8e6b1c946d50eab
Autor:
Jean-Charles Gautier, Myrtle Davis, Douglas A. Keller, Niresh Hariparsad, Jonathan A. Phillips, Radhakrishna Sura, Taraka Sai Pavan Grandhi, Terry R. Van Vleet
Publikováno v:
Lab on a Chip. 20:468-476
The human kidney contains approximately one million nephrons. As the functional unit of the kidney, the nephron affords an opportunity to approximate the kidney at a microphysiological scale. Recent emergence of physiologically accurate human tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de840a616151794554b2a7cfe1beb0ca
https://doi.org/10.1039/c9lc00925f
https://doi.org/10.1039/c9lc00925f
Autor:
Lila Ramaiah, Douglas A. Keller, Michael Merz, David Brott, Silvia Lentini, Lucas Westcott‐Baker, Paul B. Watkins, Shashi K. Ramaiah, David L. Bourdet, Ann Marie Stanley, Rachel J. Church, Sharin E. Roth, Ajit Dash, Philip J. Sherratt, Mark I. Avigan, John Marcinak
Publikováno v:
Clinical Pharmacology and Therapeutics
The diagnosis and management of drug-induced liver injury (DILI) remains a challenge in clinical trials in drug development. The qualification of emerging biomarkers capable of predicting DILI soon after the initiation of treatment, differentiating D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b75b21112abd059a7095cf1e95b7259e
http://europepmc.org/articles/PMC7006882
http://europepmc.org/articles/PMC7006882
Autor:
Allison Laura Choy, Douglas A. Keller, Matthew F. Peters, Carmen Pin, Kyle L. Kolaja, Radhakrishna Sura, Lorna Ewart, Peggy Guzzie-Peck, Clay W Scott, Derek J. Leishman, Annie Moisan
Publikováno v:
Lab on a chip. 20(7)
Drug-induced gastrointestinal toxicities (DI-GITs) are among the most common adverse events in clinical trials. High prevalence of DI-GIT has persisted among new drugs due in part to the lack of robust experimental tools to allow early detection or t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e320538b399417dfcaef5a1cd406a78a
https://pubmed.ncbi.nlm.nih.gov/32129356
https://pubmed.ncbi.nlm.nih.gov/32129356
Autor:
Douglas A. Keller, Brian R. Berridge, Ananthsrinivas Chakilam, Yvonne Will, Monicah A. Otieno, Kristin M. Fabre, David B. Duignan, Yvonne P. Dragan, Lorna Ewart, Terry R. Van Vleet, Danilo A. Tagle, Claire G. Jeong, Jinping Gan, Peggy Guzzie-Peck, Jonathan A. Phillips, Jeetu Eswaraka, Sonia M. de Morais, David E. Watson, Radhakrishna Sura, William R Proctor
Publikováno v:
Experimental Biology and Medicine. 242:1579-1585
Tissue chips are poised to deliver a paradigm shift in drug discovery. By emulating human physiology, these chips have the potential to increase the predictive power of preclinical modeling, which in turn will move the pharmaceutical industry closer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3128a14f0b4ce35a220ee4e7ecd5eeff
https://doi.org/10.1177/1535370217715441
https://doi.org/10.1177/1535370217715441
Autor:
Monicah A. Otieno, Peggy Guzzie-Peck, Thomas W. Jones, Robert J Schulingkamp, Sherry J. Morgan, Ray Kemper, Douglas A. Keller, Jessica Couch
Publikováno v:
Toxicologic Pathology. 45:372-380
An Innovation and Quality (IQ) Consortium focus group conducted a cross-company survey to evaluate current practices and perceptions around the use of animal models of disease (AMDs) in nonclinical safety assessment of molecules in clinical developme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f55e3d71fe05117175c74da158f90bcc
https://doi.org/10.1177/0192623317701004
https://doi.org/10.1177/0192623317701004
Autor:
Adrian Roth, Douglas A. Keller, Philip Hewitt, Andreas Baudy, Terry R. Van Vleet, Radhakrishna Sura, Monicah A. Otieno, Jinping Gan, William R Proctor
Publikováno v:
Lab on a chip. 20(2)
The liver is critical to consider during drug development because of its central role in the handling of xenobiotics, a process which often leads to localized and/or downstream tissue injury. Our ability to predict human clinical safety outcomes with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aad20b0de1b57f15d2012f4870b6fafb
https://pubmed.ncbi.nlm.nih.gov/31799979
https://pubmed.ncbi.nlm.nih.gov/31799979
Autor:
Thomas W. Jones, Timothy K. Hart, Maggie Liu, Michael W. Bolt, Donna Dambach, Vivek J. Kadambi, Douglas A. Keller, Thomas M. Monticello, David M. Potter
Publikováno v:
Toxicology and applied pharmacology. 334
The contribution of animal testing in drug development has been widely debated and challenged. An industry-wide nonclinical to clinical translational database was created to determine how safety assessments in animal models translate to First-In-Huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a10754d05264b32b6de539a9df6b09
https://pubmed.ncbi.nlm.nih.gov/28893587
https://pubmed.ncbi.nlm.nih.gov/28893587
Autor:
Sherry J, Morgan, Jessica, Couch, Peggy, Guzzie-Peck, Douglas A, Keller, Ray, Kemper, Monicah A, Otieno, Robert J, Schulingkamp, Thomas W, Jones
Publikováno v:
Toxicologic pathology. 45(3)
An Innovation and Quality (IQ) Consortium focus group conducted a cross-company survey to evaluate current practices and perceptions around the use of animal models of disease (AMDs) in nonclinical safety assessment of molecules in clinical developme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bb33947cabcec10854013c397ee335c4
https://pubmed.ncbi.nlm.nih.gov/28351296
https://pubmed.ncbi.nlm.nih.gov/28351296