Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Douglas S. Auld"'
Autor:
Shafqat A. Khan, Kyoung-mi Park, Laura A. Fischer, Chen Dong, Tenzin Lungjangwa, Marta Jimenez, Dominick Casalena, Brian Chew, Sabine Dietmann, Douglas S. Auld, Rudolf Jaenisch, Thorold W. Theunissen
Publikováno v:
Cell Reports, Vol 35, Iss 11, Pp 109233- (2021)
Summary: Naive human embryonic stem cells (hESCs) have been isolated that more closely resemble the pre-implantation epiblast compared to conventional “primed” hESCs, but the signaling principles underlying these discrete stem cell states remain
Externí odkaz:
https://doaj.org/article/0ab0294c046a4f59a6b32af4c1a272a8
Autor:
Keene L. Abbott, Ahmed Ali, Dominick Casalena, Brian T. Do, Raphael Ferreira, Jaime H. Cheah, Christian K. Soule, Amy Deik, Tenzin Kunchok, Daniel R. Schmidt, Steffen Renner, Sophie E. Honeder, Michelle Wu, Sze Ham Chan, Tenzin Tseyang, Daniel Greaves, Peggy P. Hsu, Christopher W. Ng, Chelsea J. Zhang, Ali Farsidjani, Iva Monique T. Gramatikov, Nicholas J. Matheson, Caroline A. Lewis, Clary B. Clish, Matthew G. Rees, Jennifer A. Roth, Lesley Mathews Griner, Alexander Muir, Douglas S. Auld, Matthew G. Vander Heiden
SUMMARYA challenge for screening new candidate drugs to treat cancer is that efficacy in cell culture models is not always predictive of efficacy in patients. One limitation of standard cell culture is a reliance on non-physiological nutrient levels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::121795f51a2d3bf410bf9d8120ac9c3b
https://doi.org/10.1101/2023.02.25.529972
https://doi.org/10.1101/2023.02.25.529972
Autor:
Nathan P. Coussens, Bridget K. Wagner, Douglas S. Auld, Jonathan R. Thielman, Jayme L. Dahlin
Publikováno v:
SLAS Discovery. 26:1280-1290
Compound-dependent assay interferences represent a continued burden in drug and chemical probe discovery. The open-source National Institutes of Health/National Center for Advancing Translational S...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0a96f504b7fb41fd8d913a52068dd68
https://doi.org/10.1177/24725552211026239
https://doi.org/10.1177/24725552211026239
Autor:
Sarine, Markossian, Kyle R, Brimacombe, G Sitta, Sittampalam, Abigail, Grossman, Nathan P, Coussens, James, Inglese, Douglas S, Auld, William, Chin, Christopher P, Austin, Matthew D, Hall
Publikováno v:
Nature reviews. Drug discovery. 21(12)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c81e7d1bcd68d2a81f64e42abf6154bb
https://pubmed.ncbi.nlm.nih.gov/36253455
https://pubmed.ncbi.nlm.nih.gov/36253455
Autor:
J. Willem M. Nissink, Jonathan B. Baell, Francis S. Willard, Ina Rothenaigner, Jonathan Z. Sexton, Douglas S. Auld, Jayme L. Dahlin, John Strelow, Michael A. Walters, Bruce K. Hua, Steve Haney, Lori Ferrins, Jarrod Walsh, Bridget K. Wagner, Jonathan A. Lee, Kamyar Hadian
Publikováno v:
Cell Chem. Bio. 28, 356-370 (2021)
Cell Chem Biol
Cell Chem Biol
Compounds that exhibit assay interference or undesirable mechanisms of bioactivity (“nuisance compounds”) are routinely encountered in cellular assays, including phenotypic and high-content screening assays. Much is known regarding compound-depen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f70a37970ff95ac15de8c8aee188c39
https://doi.org/10.1016/j.chembiol.2021.01.021
https://doi.org/10.1016/j.chembiol.2021.01.021
Autor:
Sonia M Vallabh, Arthur J. Campbell, Jayme L. Dahlin, Michael F. Mesleh, Kong T. Nguyen, Dominick Casalena, S. Kirk Wright, Dmitry L. Usanov, Christopher T. Lemke, Jamie A. Moroco, Joshua R. Sacher, Andrew G. Reidenbach, Murugappan Sathappa, Om K. Shrestha, Eric Vallabh Minikel, Jenna B. Yehl, Douglas S. Auld, Stuart L. Schreiber, V.L. Rangel, Alix I. Chan, Rishi N. Shah, Maria Cristina Nonato, David R. Liu, Florence F. Wagner, Alison Leed, Virendar K. Kaushik
Publikováno v:
J Biol Chem
Prion disease is a rapidly progressive neurodegenerative disorder caused by misfolding and aggregation of the prion protein (PrP), and there are currently no therapeutic options. PrP ligands could theoretically antagonize prion formation by protectin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec8fc34d169f5f23f5d3171c3a119372
https://doi.org/10.1074/jbc.ra120.014905
https://doi.org/10.1074/jbc.ra120.014905
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100896-(2021)
STAR Protocols
STAR Protocols
Summary Identification of selective deubiquitinase (DUB) inhibitors is critical for probe development to further understand and explore DUB biological function. Here, we detail the optimization and deployment of an in vitro fluorogenic ubiquitin-rhod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db58c22daa9efd51188bf70070b0527f
http://www.sciencedirect.com/science/article/pii/S266616672100602X
http://www.sciencedirect.com/science/article/pii/S266616672100602X
Autor:
Marta Jimenez, Ayse Okesli-Armlovich, Chaitan Khosla, Douglas S. Auld, Michael C. Bassik, Amita Gupta, Qi Liu
Publikováno v:
Bioorg Med Chem Lett
Clinically relevant inhibitors of dihydroorotate dehydrogenase (DHODH), a rate-limiting enzyme in mammalian de novo pyrimidine synthesis, have strong antiviral and anticancer activity in vitro. However, they are ineffective in vivo due to efficient u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469b722d9e42ed555458321675b6cf86
https://doi.org/10.1016/j.bmcl.2019.08.010
https://doi.org/10.1016/j.bmcl.2019.08.010
Publikováno v:
Frontiers in Pharmacology, Vol 5 (2014)
The wealth of bioactivity information now available on low-molecular weight compounds has enabled a paradigm shift in chemical biology and early phase drug discovery efforts. Traditionally chemical libraries have been most commonly employed in screen
Externí odkaz:
https://doaj.org/article/78c62af790e348b2991fc244e27c740f
Autor:
Dominick Casalena, Sabine Dietmann, Kyoung-mi Park, Tenzin Lungjangwa, Marta Jimenez, Laura A. Fischer, Chen Dong, Brian Chew, Thorold W. Theunissen, Douglas S. Auld, Shafqat Ali Khan, Rudolf Jaenisch
Publikováno v:
Cell Reports, Vol 35, Iss 11, Pp 109233-(2021)
Cell reports
Cell reports
SUMMARY Naive human embryonic stem cells (hESCs) have been isolated that more closely resemble the pre-implantation epiblast compared to conventional “primed” hESCs, but the signaling principles underlying these discrete stem cell states remain i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bad4035b5a01b85f286396f11c29de11
http://www.sciencedirect.com/science/article/pii/S2211124721005921
http://www.sciencedirect.com/science/article/pii/S2211124721005921