Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Douglas Nixon"'
Autor:
Douglas Nixon, Nicholas Dopkins
Publikováno v:
Trends in Microbiology. 31:430-431
Retroviral DNA induces the production of interferons. A new study by Yoh et al. showed that the host factor 'PQBP1' primes immune-recognition of retroviral DNA by recruiting the cytosolic DNA scavenger 'cGAS' to the HIV-1 capsid. Their findings suppo
Publikováno v:
Trends in microbiology. 30(9)
The microbiota is a collective of microorganisms whose composition is intimately linked with human health and disease. Emerging evidence demonstrates that endogenous retroviruses facilitate crosstalk between the host and microbiota to fundamentally s
Autor:
Douglas Nixon, Miguel de Mulder Rougvie, Roy Gulick, Timothy Wilkin, Rodrigo Duarte, Bruno Lima, Dennis C. Copertino Jr.
COVID-19 is the disease caused by SARS-CoV-2, and has led to over 250,000 deaths by May 2020. Urgent studies to identify new antiviral drugs, repurpose existing drugs, or identify those drugs that can specifically target the overactive immune respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::310e172d1813ed8517cec6610c514919
https://doi.org/10.26434/chemrxiv.12250199
https://doi.org/10.26434/chemrxiv.12250199
Autor:
Blake Gurfein, Andrew Stamm, Peter Bacchetti, Mary Dallman, Nachiket Nadkarni, Jeffrey Milush, Chadi Touma, Rupert Palme, Jan Pieter Konsman, Michael Acree, Mary Premenko-Lanier, Nicolas Darcel, Frederick Hecht, Douglas Nixon
Publikováno v:
European Journal of Psychotraumatology, Vol 3, Iss 0, Pp 1-1 (2012)
Chronic stress is associated with negative health outcomes and is linked with neuroendocrine changes, suppressed immunity, and central nervous system neuropathology. While human studies have illustrated the benefits of stress reduction, mechanistic u
Externí odkaz:
https://doaj.org/article/b6237b6613e64b4d9fde223f30ca72b2
Publikováno v:
European Journal of Psychotraumatology, Vol 3, Iss 0, Pp 1-1 (2012)
Chronic psychological stress increases inflammation, providing a mechanism for the elevated risk of infectious, autoimmune and cardiovascular diseases in chronically stressed persons. While the HPA axis plays an important role in mediating the link b
Externí odkaz:
https://doaj.org/article/cd80f00034674e64ac555b41b0978d1b
Autor:
Namita Kumari, Miguel de Mulder, Javed Khan, Asrar Ahmad, Songping Wang, Hatajai Lassiter, Nathan Smith, Nowah Kokou Apeadoufia Afangbedji, Andrey Ivanov, Mitsu Shah, Sharmin Diaz, Sohail Rana, Douglas Nixon, Sergei Nekhai
Publikováno v:
Blood. 132:2337-2337
BACKGROUND: Human immunodeficiency virus type 1 (HIV-1) replication is controlled by host intrinsic antiviral restriction factors some of which are counteracted by HIV-1 accessory proteins. We recently showed that ex vivo HIV-1 infection is suppresse
Publikováno v:
Scopus-Elsevier
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::45776f3cef0759e284080b9ff0ef85ed
https://ora.ox.ac.uk/objects/uuid:b96de880-763e-47fa-8e3a-15b4a0069660
https://ora.ox.ac.uk/objects/uuid:b96de880-763e-47fa-8e3a-15b4a0069660
Publikováno v:
The Journal of Immunology. 194:73.2-73.2
Role of CD8 T cells in immunoprotection against Toxoplasma gondii infection is well established. However, in an encephalitis model, CD8 immunity is functionally impaired (immune exhaustion), leading to reactivation of latent infection. Studies from o
Autor:
Devi SenGupta, Susan Ribeiro, Henri-Alexandre Michaud, Liyen Loh, Ravi Tandon, R. Jones, Keith Garrison, Vanessa York, Edecio Cunha-Neto, Mario Ostrowski, Christopher Pilcher, Frederick Hecht, Jeff Martin, Steven Deeks, Peter Hunt, Douglas Nixon
Publikováno v:
The Journal of Immunology. 190:118.21-118.21
The transcriptional silence of human endogenous retroviruses (HERV) can be disrupted in HIV-1 infection. We have reported that the strength of the HERV-specific CD8+ T cell response predicts lower HIV-1 viral load in untreated adults. To determine wh
Autor:
Martin Ivarsson, Liyen Loh, Nicole Marquardt, Niklas Björkström, Magnus Westgren, Douglas Nixon, Jakob Michaelsson
Publikováno v:
The Journal of Immunology. 190:52.46-52.46
Little is known about the human fetal immune system, but it has for long been considered as immature and unresponsive. Here we have investigated the development and function of human fetal natural killer (NK) cells. Using advanced flow cytometry, the