Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Douglas Bevan"'
Autor:
Allan D'Arcy, Nikolaus Schiering, Cary Fridrich, Yu-Hsin Chiu, Donglei Liu, Micah Hollis-Symynkywicz, Edwige Lorthiois, Hyungchul Kim, Darija Dedic, Richard Sedrani, Rose Mo, Solene Dussauge, Calhoun Amy, Stefanie Harlfinger, Treeve Currie, Simon Ruedisser, Lionel Muller, Rohit Duvadie, Ulrich Hassiepen, Adelaide Druet, Louise Kirman, Jason Elliott, Kenji Namoto, Gabriela Monnet, Francesca Perruccio, Paul Ramage, Eva Altmann, David Louis Feldman, Fabien Tritsch, Xueming Huang, Joerg Berghausen, Tanzina Fazal, Richard Zessis, James Roache, Eric T Williams, Christopher M. Adams, Wilhelm A. Weihofen, Viktor Hornak, Peter Delgado, Peter Hoffmann, David Barnes-Seeman, Douglas Bevan, ShuangXi Wang, Hong Liu, Martin Renatus, Celine Dentel, Corinne Durand, Juergen Klaus Maibaum, Guiqing Liang, Kamal Fettis, Gordon Turner, Rajeshri Ganesh Karki, Loren Lindsley, Julie Lachal, Andreas Hein
Publikováno v:
Journal of medicinal chemistry. 63(15)
The serine protease Factor XI (FXI) is a prominent drug target as it holds promise to deliver efficacious anti-coagulation without an enhanced risk of major bleeds. Several efforts have been described targeting the active form of the enzyme, FXIa. He
Autor:
Kien T. Nguyen, Chester A. Metcalf, Douglas Bevan, Jan Antoinette C. Romero, Bin Wang, Dominic Ryan, Jing Zhang, Jared Silverman, Felix Epie, Anu Daniel, Nicole M. Carter, Terence Moy, Yanzhi Zhang, Jason B. Cross, Ajit Chavan, Lippa Blaise S, Qingyi Yang, Katherine M. Poutsiaka, Joseph Shotwell, Roland E. Dolle, Brian Chamberlain, Xin Zhang
Publikováno v:
Journal of Medicinal Chemistry. 58:8503-8512
The emergence and spread of multidrug resistant bacteria are widely believed to endanger human health. New drug targets and lead compounds exempt from cross-resistance with existing drugs are urgently needed. We report on the discovery of azaindole u
Discovery of Pyrazolopyridones as a Novel Class of Gyrase B Inhibitors Using Structure Guided Design
Autor:
Jan Antoinette C. Romero, Michael F. Mesleh, Douglas Bevan, Joseph Shotwell, Ole A. Andersen, Kien T. Nguyen, Bin Wang, Jing Zhang, Katherine M. Poutsiaka, Qingyi Yang, Anu Daniel, Brian Chamberlain, Lippa Blaise S, Nicole M. Carter, Roland E. Dolle, Terence Moy, Chester A. Metcalf, Jason B. Cross, John J. Barker, M. Dominic Ryan, Jared Silverman, Felix Epie
The ATPase subunit of DNA gyrase B is an attractive antibacterial target due to high conservation across bacteria and the essential role it plays in DNA replication. A novel class of pyrazolopyridone inhibitors was discovered by optimizing a fragment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::461bdfd2f15b29c8a0f1afd5fa1ba2d4
https://europepmc.org/articles/PMC4834655/
https://europepmc.org/articles/PMC4834655/
Autor:
Anu Daniel, Chester A. Metcalf, Qingyi Yang, Roland E. Dolle, Jared Silverman, Felix Epie, Anu Arya, Jan Antoinette C. Romero, Kien T. Nguyen, Lippa Blaise S, Terence Moy, Yuchuan Wu, Jason B. Cross, Dominic Ryan, Joseph Shotwell, Douglas Bevan, Brian Chamberlain, Jing Zhang, Nicole M. Carter, Vipul Kumar, Bin Wang, Katherine M. Poutsiaka
Publikováno v:
ACS medicinal chemistry letters. 6(10)
Antibacterials with a novel mechanism of action offer a great opportunity to combat widespread antimicrobial resistance. Bacterial DNA Gyrase is a clinically validated target. Through physiochemical property optimization of a pyrazolopyridone hit, a
Autor:
Jing Zhang, Qingyi Yang, Jason B. Cross, Jan AntoinetteC. Romero, Katherine M. Poutsiaka, Felix Epie, Douglas Bevan, Bin Wang, Yanzhi Zhang, Ajit Chavan, Xin Zhang, Terence Moy, Anu Daniel, Kien Nguyen, Brian Chamberlain, Nicole Carter, Joseph Shotwell, Jared Silverman, Chester A. Metcalf, Dominic Ryan
Publikováno v:
Journal of Medicinal Chemistry; Nov2015, Vol. 58 Issue 21, p8503-8512, 10p