Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Douglas, Vollrath"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5299 (2024)
Greg Lemke’s laboratory was one of the pioneers of research into the TAM family of receptor tyrosine kinases (RTKs). Not only was Tyro3 cloned in his laboratory, but his group also extensively studied mice knocked out for individual or various comb
Externí odkaz:
https://doaj.org/article/03ec2d28b0814b34bb11b3ee6dfb288c
Autor:
Jie Ding, Sung-Jin Lee, Lukas Vlahos, Kanako Yuki, Cara C. Rada, Vincent van Unen, Meghah Vuppalapaty, Hui Chen, Asmiti Sura, Aaron K. McCormick, Madeline Tomaske, Samira Alwahabi, Huy Nguyen, William Nowatzke, Lily Kim, Lisa Kelly, Douglas Vollrath, Andrea Califano, Wen-Chen Yeh, Yang Li, Calvin J. Kuo
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Derangements of the blood-brain barrier (BBB) or blood-retinal barrier (BRB) occur in disorders ranging from stroke, cancer, diabetic retinopathy, and Alzheimer’s disease. The Norrin/FZD4/TSPAN12 pathway activates WNT/β-catenin signaling,
Externí odkaz:
https://doaj.org/article/31df630cc0d74d1eb51da2d91c5e7f3c
Autor:
Ke Ning, Mohajeet B. Bhuckory, Chien-Hui Lo, Brent E. Sendayen, Tia J. Kowal, Ming Chen, Ruchi Bansal, Kun-Che Chang, Douglas Vollrath, Nicolas F. Berbari, Vinit B. Mahajan, Yang Hu, Yang Sun
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Primary cilia are conserved organelles that integrate extracellular cues into intracellular signals and are critical for diverse processes, including cellular development and repair responses. Deficits in ciliary function cause multisystemic
Externí odkaz:
https://doaj.org/article/e3cde6ac1f29410caad2250851acad47
Autor:
Tereza Moore, Rolando E Yanes, Melissa A Calton, Douglas Vollrath, Gregory M Enns, Tina M Cowan
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0240517 (2020)
Mitochondrial diseases are a clinically heterogenous group of disorders caused by respiratory chain dysfunction and associated with progressive, multi-systemic phenotype. There is no effective treatment or cure, and no FDA-approved drug for treating
Externí odkaz:
https://doaj.org/article/743c8b3b1cd748f48faba2d1f592c372
Autor:
Inas F. Aboobakar, Tyler G. Kinzy, Yan Zhao, Baojian Fan, Louis R. Pasquale, Ayub Qassim, Antonia Kolovos, Joshua M. Schmidt, Jamie E. Craig, Jessica N. Cooke Bailey, Janey L. Wiggs, R. Rand Allingham, Murray Brilliant, Donald L. Budenz, John H. Fingert, Douglas Gaasterland, Teresa Gaasterland, Jonathan L. Haines, Michael A. Hauser, Richard K. Lee, Paul R. Lichter, Yutao Liu, Syoko Moroi, Jonathan Myers, Margaret Pericak-Vance, Anthony Realini, Doug Rhee, Julia E. Richards, Robert Ritch, Joel S. Schuman, William K. Scott, Kuldev Singh, Arthur J. Sit, Douglas Vollrath, Robert N. Weinreb, Gadi Wollstein, Donald J. Zack
Publikováno v:
Ophthalmology.
Autor:
Jie Ding, Sung-Jin Lee, Lukas Vlahos, Kanako Yuki, Cara C. Rada, Vincent van Unen, Meghah Vuppalapaty, Hui Chen, Asmiti Sura, Aaron K. McCormick, Madeline Tomaske, Samira Alwahabi, Huy Nguyen, William Nowatzke, Lily Kim, Lisa Kelly, Douglas Vollrath, Andrea J. Califano, Wen-Chen Yeh, Yang Li, Calvin J. Kuo
Derangements of the blood-brain barrier (BBB) or blood-retinal barrier (BRB) occur in disorders ranging from stroke, cancer, diabetic retinopathy, and Alzheimer’s disease. The Norrin/FZD4/TSPAN12 pathway activates WNT/β-catenin signaling, which is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19bbbd11a56b64e460faffbbd6fab7fb
https://doi.org/10.1101/2022.10.13.510564
https://doi.org/10.1101/2022.10.13.510564
Publikováno v:
Bio-Protocol, Vol 7, Iss 7 (2017)
The electroretinogram (ERG) is a sensitive and noninvasive method for testing retinal function. In this protocol, we describe a method for performing ERGs in mice. Contact lenses on the mouse cornea measure the electrical response to a light stimulus
Externí odkaz:
https://doaj.org/article/26a376f19d8d443cbabd53fb91c0e8d7
Autor:
Douglas Vollrath, Douglas Yasumura, Gillie Benchorin, Michael T Matthes, Wei Feng, Natalie M Nguyen, Cecilia D Sedano, Melissa A Calton, Matthew M LaVail
Publikováno v:
PLoS Genetics, Vol 11, Iss 12, p e1005723 (2015)
Inherited photoreceptor degenerations (IPDs) are the most genetically heterogeneous of Mendelian diseases. Many IPDs exhibit substantial phenotypic variability, but the basis is usually unknown. Mutations in MERTK cause recessive IPD phenotypes assoc
Externí odkaz:
https://doaj.org/article/19a3a470e84d47019d54bf619c2aa96c
Autor:
Xiantao Sun, Biao Yan, Jiancheng Huang, Guohua Liu, Jianhai Du, Chen Zhao, Chao Jiang, Zhichun Jiang, Shu-Jie Zhang, Shun Gu, Meng Chen, Roxana A. Radu, Xue Chen, Douglas Vollrath
Publikováno v:
Theranostics
Retinal pigment epithelial (RPE) degeneration is potentially involved in the pathogenesis of several retinal degenerative diseases. mTORC1 signaling is shown as a crucial regulator of many biological processes and disease progression. In this study,
Autor:
Jason Miller, Qitao Zhang, Sally Temple, Debra A. Thompson, Douglas Vollrath, Feriel Presswalla, David N. Zacks, Jeffrey H. Stern, Carol Charniga, Robin R. Ali, Melissa A. Calton
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose The accumulation of undigestible autofluorescent material (UAM), termed lipofuscin in vivo, is a hallmark of aged RPE. Lipofuscin derives, in part, from the incomplete degradation of phagocytized photoreceptor outer segments (OS). Whether thi