Zobrazeno 1 - 10
of 253
pro vyhledávání: '"Douglas, Thorburn"'
Autor:
Surain B. Roberts, Woo Jin Choi, Lawrence Worobetz, Catherine Vincent, Jennifer A. Flemming, Angela Cheung, Karim Qumosani, Mark Swain, Dusanka Grbic, Hin Hin Ko, Kevork M. Peltekian, Lusine Abrahamyan, Monika Saini, Kattleya Tirona, Bishoi Aziz, Ellina Lytvyak, Pietro Invernizzi, Cyriel Y. Ponsioen, Tony Bruns, Nora Cazzagon, Keith Lindor, George N. Dalekos, Nikolaos K. Gatselis, Xavier Verhelst, Annarosa Floreani, Christophe Corpechot, Marlyn J. Mayo, Cynthia Levy, Maria-Carlota Londoño, Pier M. Battezzati, Albert Pares, Frederik Nevens, Adriaan van der Meer, Kris V. Kowdley, Palak J. Trivedi, Ana Lleo, Douglas Thorburn, Marco Carbone, Nazia Selzner, Aliya F. Gulamhusein, Harry LA. Janssen, Aldo J. Montano-Loza, Andrew L. Mason, Gideon M. Hirschfield, Bettina E. Hansen
Publikováno v:
JHEP Reports, Vol 6, Iss 10, Pp 101168- (2024)
Background & Aims: Biochemical response to ursodeoxycholic acid (UDCA) therapy is associated with good prognosis in people living with primary biliary cholangitis (PBC). Biochemical response is typically assessed early in disease and it is not known
Externí odkaz:
https://doaj.org/article/8d1c44ac78ae4a3ebc2eca8571c39ace
Autor:
Maria C. van Hooff, Rozanne C. de Veer, Vincent Karam, Rene Adam, Pavel Taimr, Wojciech G. Polak, Hasina Pashtoun, Sarwa Darwish Murad, Christophe Corpechot, Darius Mirza, Michael Heneghan, Peter Lodge, Gabriel C. Oniscu, Douglas Thorburn, Michael Allison, Herold J. Metselaar, Caroline M. den Hoed, Adriaan J. van der Meer, Gabriel Oniscu, Johann Pratschke, Derek Manas, William Bennet, Pal-Dag Line, Emir Hot, Krzysztof Zieniewicz, Bo Goran Ericzon, Jiri Fronek, Jurgen L. Klempnauer, Allan Rasmussen, Renato Romagnoli, Petr Nemec, Arno Nordin, Andreas Paul, Paolo De Simone, R.J. Porte, Gabriela Berlakovich, Daniel Cherqui, Jacques Pirenne, Etienne Sokal, Giorgio Rossi, Daniel Candinas, Philippe Bachellier, Oleg Rummo, Karim Boudjema, Anna Mrzljak, Olivier Soubrane, Herold Metselaar, Stefan Schneeberger, Francis Navarro, Thierry Berney, Christophe Duvoux, Michele Colledan, Luciano De Carlis, Olivier Boillot, Jean Hardwigsen, Francois Rene Pruvot, Bertrand Suc, Marco Vivarelli, Pierre Alain Clavien, Hauke Lang, Maciej Kosieradzki, Frederik Berrevoet, Bruno Heyd, Matteo Cescon, Laurence Chiche, Eberhard Kochs, Umberto Baccarani, Olivier Detry, Michael Bartels, Massimo Rossi, Olivier Scatton, Vasileios Papanikolaou, Ian Alwayn, Peter Schemmer, N. Senninger, Christian Ducerf, Fabrizio Di Benedetto, Giuseppe Tisone, Silvio Nadalin, Zoltan Mathe, Marija Ribnikar, Utz Settmacher, Thomas Becker, Nuno Silva, Jorge Daniel, Irinel Popescu, Valerio Lucidi, Wolf O. Bechstein, Thomas Decaens, Jean Gugenheim, Salvatore Gruttadauria, Frausto Zamboni, Murat Zeytunlu, Jorg C. Kalff, Toomas Vali, Yaman Tokat, Ernst Klar, Julius Janek, Murat Kilic, Krum Katzarov, Lutz Fisher, Emmanuel Buc, Marco Castagneto, Tarkan Unek, Lubomir Spassov, Dirk Stippel, Christiane Bruns, Hans Schlitt, Ephrem Salame, Piotr Kalicinski, Koray Acarli
Publikováno v:
JHEP Reports, Vol 6, Iss 8, Pp 101100- (2024)
Background & Aims: Tacrolimus has been associated with recurrence of primary biliary cholangitis (PBC) after liver transplantation (LT), which in turn may reduce survival. This study aimed to assess the association between the type of calcineurin inh
Externí odkaz:
https://doaj.org/article/c0595d19bc354a8797ef79da5ed77889
Autor:
Louisa Stern, Constantin Schmidt, Lorenz Kocheise, Vincent Joerg, Christian Casar, Aurélie Walter, Joost P.H. Drenth, Maria Papp, Nikolaos K. Gatselis, Kalliopi Zachou, Matthias Pinter, Bernhard Scheiner, Arndt Vogel, Martha M. Kirstein, Fabian Finkelmeier, Oliver Waidmann, Arndt Weinmann, Piotr Milkiewicz, Douglas Thorburn, Neil Halliday, Ana Lleo, Samuel Huber, George N. Dalekos, Ansgar W. Lohse, Henning Wege, Johann von Felden, Kornelius Schulze
Publikováno v:
Annals of Hepatology, Vol 29, Iss 6, Pp 101534- (2024)
Introduction and Objectives: Autoimmune liver diseases (AILD) are rare causes hepatocellular carcinoma (HCC), and data on the efficacy and tolerability of anti-tumor therapies are scarce. This pan-European study aimed to assess outcomes in AILD-HCC p
Externí odkaz:
https://doaj.org/article/9c261054dc5f449a8a3e5789575e6dbb
Autor:
Gideon M. Hirschfield, Katherine Arndtz, Amanda Kirkham, Yung-Yi Chen, Richard Fox, Anna Rowe, Jessica Douglas-Pugh, Douglas Thorburn, Eleanor Barnes, Guruprasad P. Aithal, Diana Hull, Khushpreet Bhandal, Kathryn Olsen, Paul Woodward, Siân Lax, Philip Newsome, David J. Smith, Antero Kallio, David H. Adams, Victoria Homer, Chris J. Weston
Publikováno v:
Hepatology Communications, Vol 8, Iss 5 (2024)
Background:. Primary sclerosing cholangitis is a progressive inflammatory liver disease characterized by biliary and liver fibrosis. Vascular adhesion protein-1 (VAP-1) is important in the inflammatory process driving liver fibrosis. We evaluated the
Externí odkaz:
https://doaj.org/article/1b222fe6ac3c4e409c92ca04f98f474a
Autor:
Tom Snir, Raanan Greenman, Revital Aricha, Matthew Frankel, John Lawler, Francesca Saffioti, Massimo Pinzani, Douglas Thorburn, Adi Mor, Ilan Vaknin
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 6042 (2024)
Primary sclerosing cholangitis (PSC) is a rare, progressive disease, characterized by inflammation and fibrosis of the bile ducts, lacking reliable prognostic biomarkers for disease activity. Machine learning applied to broad proteomic profiling of s
Externí odkaz:
https://doaj.org/article/5271ba8a16b242f9b53d334799c779c9
Autor:
Nadir Abbas, Rachel Smith, Steven Flack, Vikram Bains, Richard J. Aspinall, Rebecca L. Jones, Laura Burke, Douglas Thorburn, Michael Heneghan, Andrew Yeoman, Joanna Leithead, Conor Braniff, Andrew Robertson, Chris Mitchell, Collette Thain, Robert Mitchell-Thain, David Jones, Palak J. Trivedi, George F. Mells, Laith Alrubaiy
Publikováno v:
JHEP Reports, Vol 6, Iss 1, Pp 100931- (2024)
Background & Aims: Guidelines for the management of primary biliary cholangitis (PBC) were published by the British Society of Gastroenterology in 2018. In this study, we assessed adherence to these guidelines in the UK National Health Service (NHS).
Externí odkaz:
https://doaj.org/article/6638b4d363f44688be9eaf62f1636999
Autor:
Laura Martinez-Gili, Alexandros Pechlivanis, Julie A.K. McDonald, Sofina Begum, Jonathan Badrock, Jessica K. Dyson, Rebecca Jones, Gideon Hirschfield, Stephen D. Ryder, Richard Sandford, Simon Rushbrook, Douglas Thorburn, Simon D. Taylor-Robinson, Mary M.E. Crossey, Julian R. Marchesi, George Mells, Elaine Holmes, David Jones
Publikováno v:
Gut Microbes, Vol 15, Iss 1 (2023)
ABSTRACTPrimary biliary cholangitis (PBC) is a chronic cholestatic liver disease with ursodeoxycholic acid (UDCA) as first-line treatment. Poor response to UDCA is associated with a higher risk of progressing to cirrhosis, but the underlying mechanis
Externí odkaz:
https://doaj.org/article/96120242cd9d46b48c536c4461b39cb1
Autor:
Davide Roccarina, Francesca Saffioti, Matteo Rosselli, Aileen Marshall, Massimo Pinzani, Douglas Thorburn
Publikováno v:
JHEP Reports, Vol 5, Iss 11, Pp 100873- (2023)
Background & Aims: Liver stiffness measurement (LSM) and spleen stiffness measurement (SSM) have been shown to be useful tools for assessing the risk of fibrosis and portal hypertension, respectively. However, data on the accuracy of LSM and SSM meas
Externí odkaz:
https://doaj.org/article/01c884ba5f59477188fb401af7cec99d
Autor:
Raanan Greenman, Michal Segal-Salto, Neta Barashi, Ophir Hay, Avi Katav, Omer Levi, Ilan Vaknin, Revital Aricha, Sarit Aharoni, Tom Snir, Inbal Mishalian, Devorah Olam, Johnny Amer, Ahmad Salhab, Rifaat Safadi, Yaakov Maor, Palak Trivedi, Christopher J. Weston, Francesca Saffioti, Andrew Hall, Massimo Pinzani, Douglas Thorburn, Amnon Peled, Adi Mor
Publikováno v:
JCI Insight, Vol 8, Iss 12 (2023)
ˆCCL24 is a pro-fibrotic, pro-inflammatory chemokine expressed in several chronic fibrotic diseases. In the liver, CCL24 plays a role in fibrosis and inflammation, and blocking CCL24 led to reduced liver injury in experimental models. We studied the
Externí odkaz:
https://doaj.org/article/db72715b10e74e2cbaca199c73a4f4ca
Autor:
Raanan Greenman, Tom Snir, Avi Katav, Revital Aricha, Inbal Mishalian, Ophir Hay, Matthew Frankel, John Lawler, Francesca Saffioti, Massimo Pinzani, Douglas Thorburn, Amnon Peled, Adi Mor, Ilan Vaknin
Publikováno v:
Cells, Vol 13, Iss 3, p 209 (2024)
Primary sclerosing cholangitis (PSC) is an inflammatory and fibrotic biliary disease lacking approved treatment. We studied CCL24, a chemokine shown to be overexpressed in damaged bile ducts, and its involvement in key disease-related mechanisms. Ser
Externí odkaz:
https://doaj.org/article/a1816b5cfdb34b9c952e2116924ccc70