Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Douglas, Funk"'
Publikováno v:
Neuropharmacology. 215
The neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) modulates fundamental motivational processes, and the neurochemical and behavioural effects of drugs of abuse. Recently, attention has focused on the role of 5-HT acting via 5-HT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad2781e92ccd5a12b3fb115b0adc0abb
https://pubmed.ncbi.nlm.nih.gov/35644487
https://pubmed.ncbi.nlm.nih.gov/35644487
Publikováno v:
Behavioural Brain Research. 434:114032
Noradrenaline and alpha-2 receptors are implicated in the neuroadaptive changes in alcohol dependence leading to increased alcohol seeking. Preclinical methods often used to induce dependence, such as alcohol vapor, require long exposure periods. Ano
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc94880619da3721bce595299404356
https://doi.org/10.1016/j.bbr.2022.114032
https://doi.org/10.1016/j.bbr.2022.114032
Autor:
Anh D. Lê, Alexandrine L. Martel, Leila Mousavifar, Jordan D. Lewicky, Hoang-Thanh Le, Thi M.-D. Nguyen, René Roy, Douglas Funk, Nya L. Fraleigh, Peter W. Schiller
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 15
International Journal of Molecular Sciences, Vol 22, Iss 7996, p 7996 (2021)
Volume 22
Issue 15
International Journal of Molecular Sciences, Vol 22, Iss 7996, p 7996 (2021)
Peptide therapeutics offer numerous advantages in the treatment of diseases and disorders of the central nervous system (CNS). However, they are not without limitations, especially in terms of their pharmacokinetics where their metabolic lability and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c96bed9f96be01a94d61a9d016a901c6
Publikováno v:
Neuropsychopharmacology. 43:1859-1866
Dependence on drugs has enduring effects on drug intake and relapse. The role of choice in enhanced susceptibility to drug use in drug dependence has been little studied. Here we determine the effects of alcohol dependence on the choice between alcoh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dc11df323dbd66ec9ad1803556c4c00
https://doi.org/10.1038/s41386-018-0101-1
https://doi.org/10.1038/s41386-018-0101-1
Publikováno v:
International Journal of Neuropsychopharmacology
Background Stress is associated with relapse to alcohol seeking during abstinence, but the processes underlying this relationship are poorly understood. Noradrenaline is a key transmitter in stress responses and in stress-induced drug seeking. The al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99ee8d10609128f783e92917860abe98
https://doi.org/10.1093/ijnp/pyz049
https://doi.org/10.1093/ijnp/pyz049
Publikováno v:
Neuropharmacology. 148
Alcohol dependence and stress are associated with relapse to alcohol during abstinence, but the underlying mechanisms are poorly understood. Kappa opioid receptors (KOR) are involved in alcohol reward and in the effects of stress. Previously, in non-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a70ddaa82e2550fe43207df5912860bc
https://pubmed.ncbi.nlm.nih.gov/30659838
https://pubmed.ncbi.nlm.nih.gov/30659838
Publikováno v:
Neuropsychopharmacology. 41:335-356
In human addicts, drug relapse and craving are often provoked by stress. Since 1995, this clinical scenario has been studied using a rat model of stress-induced reinstatement of drug seeking. Here, we first discuss the generality of stress-induced re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c717d131b4f34cc5a215f9daab78c07a
https://doi.org/10.1038/npp.2015.142
https://doi.org/10.1038/npp.2015.142
Publikováno v:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 43(4)
κ-Opioid receptors (KORs) and their endogenous ligand dynorphin are involved in stress-induced alcohol seeking but the mechanisms involved are largely unknown. We previously showed that systemic injections of the KOR agonist U50,488, which induce st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5f3ffef802bbe068bc03548ea7616a7
https://pubmed.ncbi.nlm.nih.gov/28589966
https://pubmed.ncbi.nlm.nih.gov/28589966
Role of the kappa-opioid receptor system in stress-induced reinstatement of nicotine seeking in rats
Publikováno v:
Behavioural Brain Research. 265:188-197
Rationale The correlation between stress and smoking is well established. The mechanisms that underlie this relationship are, however, unclear. Recent data suggest that the kappa-opioid system is involved in the mediation of negative affective states
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2449817fef4cba25377ad9283c51bb15
https://doi.org/10.1016/j.bbr.2014.02.029
https://doi.org/10.1016/j.bbr.2014.02.029
Publikováno v:
Brain and Behavior
Introduction Stress is related to heavy alcohol use and relapse in alcoholics. Using the reinstatement model, we have shown that corticotropin-releasing factor (CRF) underlies stress-induced relapse to alcohol seeking in laboratory rodents. Little is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35732c56304aa54ed551f2f0684b1af7
http://europepmc.org/articles/PMC4055186
http://europepmc.org/articles/PMC4055186