Capturing Dynamic Assembly of Nanoscale Proteins During Network Formation.

Autor: Hughes MDG; School of Physics and Astronomy, Faculty of Engineering and Physical Sciences, University of Leeds, Leeds, LS2 9JT, UK., Cook KR; School of Physics and Astronomy, Faculty of Engineering and Physical Sciences, University of Leeds, Leeds, LS2 9JT, UK., Cussons S; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK.; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK., Boroumand A; School of Physics and Astronomy, Faculty of Engineering and Physical Sciences, University of Leeds, Leeds, LS2 9JT, UK., Tyler AII; School of Food Science and Nutrition, Faculty of Environment, University of Leeds, Leeds, LS2 9JT, UK., Head D; School of Computer Science, Faculty of Engineering and Physical Sciences, University of Leeds, Leeds, LS2 9JT, UK., Brockwell DJ; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK.; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK., Dougan L; School of Physics and Astronomy, Faculty of Engineering and Physical Sciences, University of Leeds, Leeds, LS2 9JT, UK.; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK.

Publikováno v: Small (Weinheim an der Bergstrasse, Germany) [Small] 2024 Nov 12, pp. e2407090. Date of Electronic Publication: 2024 Nov 12.

Methanol-water solutions: a bi-percolating liquid mixture

Autor: Dougan, L., Bates, S. P., Hargreaves, R., Fox, J. P., Crain, J., Finney, J. L., Reat, V., Soper, A. K.

Publikováno v: J Chem Phys 121(13) (2004) 6456-6462

An extensive series of neutron diffraction experiments and molecular dynamics simulations has shown that mixtures of methanol and water exhibit extended structures in solution despite the components being fully miscible in all proportions. Of particu

Externí odkaz: http://arxiv.org/abs/cond-mat/0412436

Trimethylamine-N-oxide depletes urea in a peptide solvation shell.

Autor: Nasralla M; School of Physics and Astronomy, University of Leeds, Leeds LS2 9JT, United Kingdom., Laurent H; School of Physics and Astronomy, University of Leeds, Leeds LS2 9JT, United Kingdom., Alderman OLG; Disordered Materials Group, ISIS Neutron and Muon Source, Rutherford Appleton Laboratory, Didcot OX11 0QX, United Kingdom., Headen TF; Disordered Materials Group, ISIS Neutron and Muon Source, Rutherford Appleton Laboratory, Didcot OX11 0QX, United Kingdom., Dougan L; School of Physics and Astronomy, University of Leeds, Leeds LS2 9JT, United Kingdom.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Apr 02; Vol. 121 (14), pp. e2317825121. Date of Electronic Publication: 2024 Mar 27.

Building block aspect ratio controls assembly, architecture, and mechanics of synthetic and natural protein networks.

Autor: Hughes MDG; School of Physics and Astronomy, Faculty of Engineering and Physical Sciences, University of Leeds, Leeds, UK., Cussons S; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK.; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK., Hanson BS; School of Physics and Astronomy, Faculty of Engineering and Physical Sciences, University of Leeds, Leeds, UK., Cook KR; School of Physics and Astronomy, Faculty of Engineering and Physical Sciences, University of Leeds, Leeds, UK., Feller T; Leeds Institute of Cardiovascular and Metabolic Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, UK., Mahmoudi N; ISIS Neutron and Muon Spallation Source, STFC Rutherford Appleton Laboratory, Oxfordshire, UK., Baker DL; School of Physics and Astronomy, Faculty of Engineering and Physical Sciences, University of Leeds, Leeds, UK., Ariëns R; Leeds Institute of Cardiovascular and Metabolic Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, UK., Head DA; School of Computing, Faculty of Engineering and Physical Science, University of Leeds, Leeds, UK., Brockwell DJ; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK.; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK., Dougan L; School of Physics and Astronomy, Faculty of Engineering and Physical Sciences, University of Leeds, Leeds, UK. L.Dougan@leeds.ac.uk.; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK. L.Dougan@leeds.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2023 Sep 11; Vol. 14 (1), pp. 5593. Date of Electronic Publication: 2023 Sep 11.

Modeling the mechanical stiffness of pancreatic ductal adenocarcinoma

Autor: Kpeglo, D, Hughes, MDG, Dougan, L, Haddrick, M, Knowles, MA, Evans, SD, Peyman, SA

Publikováno v: Matrix Biology Plus. 14:100109

Despite improvements in the understanding of disease biology, pancreatic ductal adenocarcinoma (PDAC) remains the most malignant cancer of the pancreas. PDAC constitutes ∼95% of all pancreatic cancers, and it is highly resistant to therapeutics. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49d43d87e70e50b0e7d127d4d16cc924
https://doi.org/10.1016/j.mbplus.2022.100109