Zobrazeno 1 - 10
of 182
pro vyhledávání: '"Dougald M. Monroe"'
Autor:
Michael T. Stobb, Keith B. Neeves, Dougald M. Monroe, Suzanne S. Sindi, Karin Leiderman, Aaron L. Fogelson
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 8, Iss 7, Pp 102570- (2024)
Background: In healthy individuals, plasma levels of clotting proteins naturally vary within a range of 50% to 150% of their mean values. We do not know how these variations modify thrombin generation. Objectives: To assess the impact of protein leve
Externí odkaz:
https://doaj.org/article/5959f88105c5471ea4dee64b871e704a
Autor:
Cho Yeow Koh, Norrapat Shih, Christina Y. C. Yip, Aaron Wei Liang Li, Weiming Chen, Fathiah S. Amran, Esther Jia En Leong, Janaki Krishnamoorthy Iyer, Grace Croft, Muhammad Ibrahim Bin Mazlan, Yen-Lin Chee, Eng-Soo Yap, Dougald M. Monroe, Maureane Hoffman, Richard C. Becker, Dominique P. V. de Kleijn, Vaishali Verma, Amita Gupta, Vijay K. Chaudhary, A. Mark Richards, R. Manjunatha Kini, Mark Y. Chan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Bleeding complications limits the use of effective antithrombotics therapeutics. Here, the authors developed next-generation direct thrombin inhibitors with low bleeding risks as safe peri-percutaneous coronary intervention anticoagulants when used i
Externí odkaz:
https://doaj.org/article/cad6e99b695d4c66a9002c62027f15b1
Autor:
Michael W. Henderson, Denis F. Noubouossie, Anton Ilich, Kathy J. Wilson, Rafal Pawlinski, Dougald M. Monroe, Nigel S. Key
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 4, Iss 5, Pp 789-798 (2020)
Abstract Mounting evidence suggests that a variety of disease states are pathophysiologically related to activation of the contact system in vivo. The plasma contact system is composed of a cascade of serine proteases initiated by surface activation
Externí odkaz:
https://doaj.org/article/ef9e3503ced04bb0a1cc394be1c50aa8
Publikováno v:
Platelets, Vol 31, Iss 4, Pp 417-422 (2020)
Hemostasis is the normal process that produces a blood clot at a site of vascular injury. Mice are widely used to study hemostasis and abnormalities of blood coagulation because their hemostatic system is similar in most respects to that of humans, a
Externí odkaz:
https://doaj.org/article/ca5571e14903401283fc39f6f97c73a1
Publikováno v:
Advances in Hematology, Vol 2016 (2016)
The goal of these studies was to extensively characterize the first recombinant FIX therapeutic corresponding to the threonine-148 (Thr-148) polymorph, IXINITY (trenonacog alfa [coagulation factor IX (recombinant)]). Gel electrophoresis, circular dic
Externí odkaz:
https://doaj.org/article/2d65397166a646c596e5cbe7ffed7bce
Autor:
Stéphanie E. Reitsma, Lori A. Holle, Emma G. Bouck, Dougald M. Monroe, Alan E. Mast, John Burthem, Paula H.B. Bolton-Maggs, Gillian N. Gidley, Alisa S. Wolberg
Publikováno v:
Journal of Thrombosis and Haemostasis. 21:467-479
Autor:
Mark Y. Chan, Dougald M. Monroe, Norrapat Shih, Richard C. Becker, Aaron Wei Liang Li, Amita Gupta, R. Manjunatha Kini, Esther Jia En Leong, Eng Soo Yap, Janaki Krishnamoorthy Iyer, Vijay K. Chaudhary, Maureane Hoffman, Grace Croft, Yen-Lin Chee, Fathiah S Amran, Muhammad Ibrahim Bin Mazlan, Weiming Chen, A. Mark Richards, Dominique P.V. de Kleijn, Christina Yip, Cho Yeow Koh, Vaishali Verma
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
Despite their limitations, unfractionated heparin (UFH) and bivalirudin remain standard-of-care parenteral anticoagulants for percutaneous coronary intervention (PCI). We discovered novel direct thrombin inhibitors (DTIs) from tick salivary transcrip
Autor:
Dougald M. Monroe, Christine Baird, Julie A. Peterson, Alan E. Mast, Marilyn Manco-Johnson, Michael Stobb, Suzanne Sindi, Aaron L. Fogelson, Karin Leiderman, Keith B. Neeves
Bleeding patterns in people with hemophilia A cannot be predicted solely by factor VIII (FVIII) levels. Some of the variance in bleeding may be attributed to differences in plasma protein composition, and specifically other coagulation factors where
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b97d3c9674ec30f5f333671e7f542535
https://doi.org/10.1101/2022.06.27.496845
https://doi.org/10.1101/2022.06.27.496845
Autor:
Michael W. Henderson, Maureane Hoffman, Thomas Renné, Micah J. Mooberry, Rafal Pawlinski, Anton Ilich, Nigel S. Key, Patrick Ellsworth, Dougald M. Monroe, Denis F. Noubouossie, Ian J. Welsby, Mark Piegore, Sarah Skinner
Publikováno v:
Blood. 135:755-765
Storage lesion–induced, red cell–derived microvesicles (RBC-MVs) propagate coagulation by supporting the assembly of the prothrombinase complex. It has also been reported that RBC-MVs initiate coagulation via the intrinsic pathway. To elucidate t
Autor:
Darón I. Freedberg, David D. Holcomb, Ryan C. Hunt, Kazuyo Takeda, Amy D. Gelinas, Dougald M. Monroe, Puja Nanavaty, Robert Peters, John C. Athey, Zuben E. Sauna, Vijaya L. Simhadri, Aikaterini Alexaki, Nebojsa Janjic, Nobuko Hamasaki-Katagiri, Joseph R. McGill, Michael DiCuccio, Upendra K. Katneni, Jacob Kames, Haim Bar, Anton A. Komar, Gaya K. Hettiarachchi, Brian Lin, Chava Kimchi-Sarfaty
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports
Scientific Reports
Synonymous codons occur with different frequencies in different organisms, a phenomenon termed codon usage bias. Codon optimization, a common term for a variety of approaches used widely by the biopharmaceutical industry, involves synonymous substitu