Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Doug W Smith"'
Publikováno v:
Frontiers in Pharmacology, Vol 3 (2012)
Complex neuroadaptations within key nodes of the brain’s ‘reward circuitry’ are thought to underpin long-term vulnerability to relapse. A more comprehensive understanding of the molecular and cellular signalling events that subserve relapse vul
Externí odkaz:
https://doaj.org/article/be199d0b6ec14a85ae40a7f7f093a745
Publikováno v:
Brain and Behavior, Vol 13, Iss 8, Pp n/a-n/a (2023)
Abstract Introduction The efferent vestibular system (EVS) is a feedback circuit thought to modulate vestibular afferent activity by inhibiting type II hair cells and exciting calyx‐bearing afferents in the peripheral vestibular organs. In a previo
Externí odkaz:
https://doaj.org/article/7dabe2408144455dbdc792d9e34bb3eb
Autor:
Lauren A Poppi, Mark J Bigland, Ethan T Cresswell, Hessam Tabatabaee, David Lorincz, Hannah R Drury, Robert J Callister, Joseph C Holt, Rebecca Lim, Alan M Brichta, Doug W Smith
Publikováno v:
The Journals of Gerontology: Series A.
Cholinergic circuits in the central nervous system are vulnerable to age-related functional decline, but it is not known if aging impacts cholinergic signaling in the vestibular sensory organs, which are critically important to balance maintenance an
Autor:
Annie-Louise Robson, Paul C. Dastoor, Jamie Flynn, William Palmer, Antony Martin, Doug W. Smith, Ameha Woldu, Susan Hua
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
There are currently a number of imaging techniques available for evaluating the morphology of liposomes and other nanoparticles, with each having its own advantages and disadvantages that should be considered when interpreting data. Controlling and v
Externí odkaz:
https://doaj.org/article/07d5670724124c16988aba35eff8aa14
Autor:
J. Mayhew, Ethan T Cresswell, Brett A. Graham, Robert J. Callister, Doug W. Smith, Mitchell J Cummins
Publikováno v:
Mol Pain
Clinically, pain has an uneven incidence throughout lifespan and impacts more on the elderly. In contrast, preclinical models of pathological pain have typically used juvenile or young adult animals to highlight the involvement of glial populations,
Autor:
Patricia T. Michie, Paul A. Tooney, Mark J. Bigland, Ryan J. Duchatel, Deborah M. Hodgson, Lauren Harms, Crystal L. Meehan, Doug W. Smith, Phillip Jobling, Frederick R. Walker
Publikováno v:
Psychiatry Research. 266:175-185
Animal models of maternal immune activation study the effects of infection, an environmental risk factor for schizophrenia, on brain development. Microglia activation and cytokine upregulation may have key roles in schizophrenia neuropathology. We hy
Autor:
Simon Keely, Daniel J. McIlroy, Philip M. Hansbro, Zsolt J. Balogh, Natalie Lott, Doug W. Smith, Kyra Minahan
Publikováno v:
Journal of Trauma and Acute Care Surgery. 85:354-358
© 2018 Wolters Kluwer Health, Inc. All rights reserved. BACKGROUND Cell-free mitochondrial DNA (mtDNA) is proinflammatory and has been detected in high concentrations in trauma patients' plasma. Deoxyribonuclease (DNAse) is the free plasma enzyme re
Autor:
Murray J. Cairns, Morgan H. James, Guy E. Hawkins, Christopher V. Dayas, Andrew Heathcote, Doug W. Smith, Rikki K. Quinn, Amanda L. Brown
Publikováno v:
Addiction Biology. 23:631-642
MicroRNAs (miRNAs) within the ventral and dorsal striatum have been shown to regulate addiction-relevant behaviours. However, it is unclear how cocaine experience alone can alter the expression of addiction-relevant miRNAs within striatal subregions.
Autor:
Alan M. Brichta, Eugene Nalivaiko, Doug W. Smith, Lauren Ashlee Poppi, Ethan T Cresswell, Longlong Tu, John A. Rudd
Publikováno v:
Physiology & Behavior. 174:114-119
Hypothermic responses accompany motion sickness in humans and can be elicited by provocative motion in rats. We aimed to determine the potential role in these responses of the efferent cholinergic vestibular innervation. To this end, we used knockout
Publikováno v:
Molecular Pain
A well-recognized relationship exists between aging and increased susceptibility to chronic pain conditions, underpinning the view that pain signaling pathways differ in aged individuals. Yet despite the higher prevalence of altered pain states among