Zobrazeno 1 - 1
of 1
pro vyhledávání: '"Doug J. Minick"'
Autor:
Philip Alan Skone, Iain Uings, Davina Humphreys, Diane M. Coe, George Hardy, Simon J. F. Macdonald, Doug J. Minick, Richard Loiseau, Haydn Terence Jones, Iain M. McLay, David House, Derek A. Demaine, Michael John Johnston, Graham G. A. Inglis, Margaret Clackers
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:4737-4745
Starting from an established series of non-steroidal glucocorticoid receptor (GR) agonists, a large array was designed where a metabolically labile benzoxazinone moiety was replaced. Initial hits bound to GR but lacked agonist activity. Following two