Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Doug J. Jolly"'
Autor:
Maria Rodriguez-Aguirre, Harry E. Gruber, Doug J. Jolly, Leah Mitchell, Michael A. Vogelbaum, Timothy F. Cloughesy, Danilella Bota, Steven N. Kalkanis, Tom Mikkelsen, Tobias Walbert, Linda M. Liau, Derek Ostertag, Jolene Shorr
Publikováno v:
Neuro-Oncology. 19:vi265-vi266
Toca 511 (vocimagene amiretroprepvec) is an investigational, conditionally lytic, retroviral replicating vector that encodes an optimized yeast cytosine deaminase (CD) gene. The CD gene converts the prodrug, Toca FC (investigational, extended-release
Autor:
Dan Pertschuk, Michael A. Vogelbaum, Joan M. Robbins, David Piccioni, Stephen Bloomfield, Christine Pan, Santosh Kesari, Steven N. Kalkanis, E. Antonio Chiocca, Greg Foltz, Timothy F. Cloughesy, Derek Ostertag, Joseph Landolfi, J. Bradley Elder, Carlos E. Ibanez, Doug J. Jolly, Tom Mikkelsen, Linda M. Liau, Clark C. Chen
INTRODUCTION: Recurrent high grade glioma (rHGG) remains one of the most deadly cancers. Investigational agents Toca 511, a retroviral replicating vector, and Toca FC (extended-release 5-FC) are used in combination to target residual tumor at the tim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f45a7163216364e228962f4f01e40cfb
https://europepmc.org/articles/PMC4218255/
https://europepmc.org/articles/PMC4218255/
Autor:
Helmuth H. G. van Es, Joseph Zabner, Paul B. McCray, Doug J. Jolly, Vladimir Slepushkin, Mordechai Bodner, Guoshun Wang, Patricia A. Thomas, Beverly L. Davidson
Publikováno v:
The Journal of Gene Medicine. 1:22-30
Background Cell proliferation, vector titer and accessibility of target cells represent hurdles for efficient gene transfer to lung epithelia in vivo using recombinant murine leukemia (MuLV)-based retroviruses. We tested the hypothesis that the pulmo
Autor:
Carlos E. Ibanez, Gerhard Bauer, Donald B. Kohn, Doug J. Jolly, Sybille L. Sauter, Penelope Valdez, C. Robert Rice
Publikováno v:
Europe PubMed Central
ResearcherID
ResearcherID
Using retroviral supernatants derived from the amphotropic murine packaging cell line PA317 and the amphotropic canine packaging cell line (DA), cord blood and mobilized peripheral blood CD34+ cells were transduced with the vector LN (neomycin resist
Autor:
Sunil Chada, Beverly L. Davidson, Joel N. Kline, Joseph Zabner, Guoshun Wang, Paul B. McCray, Doug J. Jolly, Steven M. W. Chang
Publikováno v:
Human Gene Therapy. 8:1087-1093
Gene transfer with integrating vectors such as recombinant retrovirus has the potential to correct inherited lung diseases permanently. As a gene therapy target, the pulmonary epithelium presents several challenges to vector delivery in vivo. Many of
Autor:
Steven N. Kalkanis, J. Bradley Elder, Timothy F. Cloughesy, Tom Mikkelsen, Alice Chu, Jamey Skillings, Joan M. Robbins, Santosh Kesari, Derek Ostertag, Clark C. Chen, Mary Rose Keller, Joseph Landolfi, Doug J. Jolly, Michael A. Vogelbaum
Publikováno v:
Neuro-Oncology. 17:v216.1-v216
Autor:
Manish K. Aghi, Derek Ostertag, J. Bradley Elder, Michael A. Vogelbaum, Charles Cobbs, Santosh Kesari, Andreas Niethammer, Doug J. Jolly, Tom Mikkelsen, Alice Chu, Samuel Singer, Mary Rose Keller, Joan M. Robbins, Joseph Landolfi, Timothy F. Cloughesy
Publikováno v:
Neuro-Oncology. 17:v108.1-v108
Investigational Toca 511, a retroviral replicating vector, and Toca FC (extended-release flucytosine) are used in combination to target recurrent high grade glioma at resection by transducing the tumor with the gene encoding cytosine deaminase, conve
Autor:
Nancy Sajjadi, Tammi Howard, Wilson Edwards, Doug J. Jolly, Edgar Kamantigue, Steven Mento, Sunil Chada
Publikováno v:
Human Gene Therapy. 5:693-699
A murine retroviral vector encoding the human immunodeficiency virus type 1 (HIV-1) env and rev genes can be used to induce cytotoxic T lymphocyte responses. Immune responses can be induced by an ex vivo treatment, in which autologous cells are trans
Autor:
Tom Mikkelsen, Harry E. Gruber, Steven N. Kalkanis, Joan M. Robbins, Derek Ostertag, Dan Pertschuk, Doug J. Jolly, Tiffany T. Huang
Publikováno v:
Neuro-Oncology. 16:v15-v15
INTRODUCTION: Toca 511 (vocimagene amiretrorepvec) is an investigational retroviral replicating vector (RRV) that encodes the transgene cytosine deaminase (CD). Subsequent oral administration of investigational extended-release 5-FC (Toca FC) results
Autor:
Sue Koop, Doug J. Jolly, Kenneth Cornetta, Yi Xu, Holger Roehl, Aparna Jasti, Lisa Duffy, Lakshmi Sastry
Publikováno v:
Human gene therapy. 16(10)
The product-enhanced reverse transcriptase (PERT) assay has been used to detect reverse transcriptase (RT) activity associated with retroviruses. Although the PERT assay has been proposed as a method for detection of replication-competent retrovirus