Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Doug Hussey"'
Autor:
Alan A. Wilson, Nicholaas Paul L.G. Verhoeff, Krista L. Lanctôt, Pablo Rusjan, Nathan Herrmann, Doug Hussey, Nicole Kozloff, Sandra E. Black, Sylvain Houle, Shitij Kapur
Publikováno v:
The American Journal of Geriatric Psychiatry. 15:888-898
Objective The important role of serotonin-1A (5-hydroxytryptamine-1A [5-HT 1A ]) receptors in cognition, behavior, and drug response is increasingly being recognized. Postmortem studies suggest decreased 5-HT 1A receptors in patients with Alzheimer d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::589ad2a4449091ed3a2eab794aa7a9c6
https://doi.org/10.1097/jgp.0b013e3180488325
https://doi.org/10.1097/jgp.0b013e3180488325
Autor:
Patrick McCormick, Sylvain Houle, Doug Hussey, Alan A. Wilson, Nathalie Ginovart, Matthaeus Willeit, Shitij Kapur, Philip Seeman, Armando Garcia
Publikováno v:
Journal of Medicinal Chemistry. 48:4153-4160
In vivo imaging of dopamine D2 receptors with agonist (as opposed to the more commonly employed antagonist) radiotracers could provide important information on the high-affinity (functional) state of the D2 receptor in illnesses such as schizophrenia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2599a7984d697395ddf721ff1c83201
https://doi.org/10.1021/jm050155n
https://doi.org/10.1021/jm050155n
Autor:
Nicolaas P.L.G. Verhoeff, Alan A. Wilson, Shinichiro Takeshita, Liat Trop, Doug Hussey, Kernjit Singh, Hank F. Kung, Mei-Ping Kung, Sylvain Houle
Publikováno v:
American Journal of Geriatric Psychiatry. 12:584-595
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f6470a8ea0ed68edecfbb535b811cd2
https://doi.org/10.1097/00019442-200411000-00004
https://doi.org/10.1097/00019442-200411000-00004
Autor:
Alan A. Wilson, Jeffrey H. Meyer, Andy Cheok, Sandra Sagrati, William Z. Potter, Doug Hussey, Sylvain Houle, Nathalie Ginovart, Edgar P. Spencer, Anna Carella
Publikováno v:
American Journal of Psychiatry. 161:826-835
Minimum therapeutic doses of paroxetine and citalopram produce 80% occupancy for the serotonin (5-HT) transporter (5-HTT). The authors used [(11)C]DASB positron emission tomography to measure occupancies of three other selective serotonin reuptake in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c821588d8c332166278f9123ce3850f1
https://doi.org/10.1176/appi.ajp.161.5.826
https://doi.org/10.1176/appi.ajp.161.5.826
Autor:
Glen B. Baker, Gary Remington, Raman Chirakal, Shitij Kapur, Sylvain Houle, David C. Mamo, Alan A. Wilson, Doug Hussey, José N. Nobrega
Publikováno v:
Synapse. 52:153-162
Clinical effects of antipsychotic drugs are thought to be mediated primarily through antagonism of the dopamine D2 receptors. Recent studies have demonstrated increased aromatic decarboxylase activity following acute administration of dopamine D2 rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af883bc851bcf525441c14d04bc7b86c
https://doi.org/10.1002/syn.20016
https://doi.org/10.1002/syn.20016
Autor:
David Patrick Johnson, José N. Nobrega, Alan A. Wilson, Doug Hussey, David Mozley, Armando Garcia, Sylvain Houle, Nathalie Ginovart, J Meyer
Publikováno v:
Nuclear Medicine and Biology. 30:85-92
The (R,R) and (S,S) enantiomers of 2-[(2-methoxyphenoxy)phenylmethyl]morpholine (MeNER) have been radiolabelled with carbon-11 in good yield and at high specific activity. These radiotracers are close analogues of reboxetine, a potent and selective l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1f336d242bd074d06d5aec283daeced
https://doi.org/10.1016/s0969-8051(02)00420-1
https://doi.org/10.1016/s0969-8051(02)00420-1
Publikováno v:
Synapse. 47:123-133
The in vivo pharmacological profile of [(11)C]-DASB, a new radioligand developed for in vivo imaging of the serotonin transporter (SERT), was evaluated in the cat brain using positron emission tomography (PET). The in vivo distribution of [(11)C]-DAS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b54b0f58bb8cefe639311853ba418ad1
https://doi.org/10.1002/syn.10155
https://doi.org/10.1002/syn.10155
Autor:
Jeffrey H. Meyer, Doug Hussey, Verdell S. Goulding, Alan A. Wilson, Sylvain Houle, Bruce K. Christensen
Publikováno v:
Psychopharmacology. 163:102-105
Bupropion is thought to treat major depression by blocking the dopamine transporter (DAT) because bupropion appears to have a selective affinity for the DAT. The validity of this mechanism has been questioned because the affinity of bupropion for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c515d946a13feccb3f20a621562922c
https://doi.org/10.1007/s00213-002-1166-3
https://doi.org/10.1007/s00213-002-1166-3
Autor:
Johannes Tauscher, Alan A. Wilson, M Lee, Nicolaas Paul L.G. Verhoeff, Sylvain Houle, George Papatheodorou, Shitij Kapur, Doug Hussey
Publikováno v:
Molecular Psychiatry. 7:322-328
The effect of endogenous dopamine (DA) on neostriatal DA D(1) and D(2) receptor binding potentials (D(1)RBP and D(2)RBP, respectively) in vivo was evaluated with positron emission tomography (PET) and the radiotracers [(11)C]SCH23390 and [(11)C]raclo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::025e05976f723e0ca5e992863457be02
https://doi.org/10.1038/sj.mp.4001057
https://doi.org/10.1038/sj.mp.4001057
Autor:
Doug Hussey, Ayal Schaffer, Stephanie Krüger, Sidney H. Kennedy, Alan A. Wilson, Bruce K. Christensen, Sylvain Houle, Candace E. Minifie, Jeffrey H. Meyer, Verdell S. Goulding
Publikováno v:
Neuroreport. 12:4121-4125
Previous studies suggest that there is a dopamine lowering process during major depressive episodes (MDE). To investigate this, we measured the dopamine transporter binding potential (DAT BP) in the striatum of depressed and healthy subjects using [(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5027bb1d175a7e02ced19bf595fd9f52
https://doi.org/10.1097/00001756-200112210-00052
https://doi.org/10.1097/00001756-200112210-00052