Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Doug Burdette"'
Autor:
Sameer C. Dhamne, Meera E. Modi, Audrey Gray, Simone Bonazzi, Lucas Craig, Elizabeth Bainbridge, Lahin Lalani, Chloe E. Super, Samantha Schaeffer, Ketthsy Capre, Danuta Lubicka, Guiqing Liang, Doug Burdette, Stephanie M. McTighe, Sarika Gurnani, Sheryl Anne D. Vermudez, Daniel Curtis, Christopher J. Wilson, Mustafa Q. Hameed, Angelica D'Amore, Alexander Rotenberg, Mustafa Sahin
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 10, Iss 10, Pp 1790-1801 (2023)
Abstract Objective Tuberous sclerosis complex (TSC) is a neurodevelopmental disorder caused by autosomal‐dominant pathogenic variants in either the TSC1 or TSC2 gene, and it is characterized by hamartomas in multiple organs, such as skin, kidney, l
Externí odkaz:
https://doaj.org/article/5e6e60c1d4644ed1b4ab20f434f5f54a
Autor:
Bin Ma, Urjana Poreci, Luisette Delva, Fengmei Zhang, Hao Tang, Tonika Bohnert, Patricia Schroeder, Richard Grater, Sudarshan Kapadnis, Kris King, Michael Mingueneau, Marc Hoemberger, Evelyne Polack, Brian T. Hopkins, Prince Robin, Chris Rowbottom, Robert Meissner, Eris Bame, Joseph C Santoro, Paramasivam Murugan, Allie M Roach, Claire M. Metrick, Kevin L. Otipoby, Eric Tien, Josh Johnson, Douglas Donaldson, Joseph P. Lyssikatos, Doug Burdette, Tom Magee, Carrie Boiselle, Chungang Gu, Mukesh Lulla, Bekim Bajrami, Jeremy C. Burns, Cheryl Black, Marx Isaac
Publikováno v:
Journal of medicinal chemistry. 65(2)
Multiple Sclerosis is a chronic autoimmune neurodegenerative disorder of the central nervous system (CNS) that is characterized by inflammation, demyelination, and axonal injury leading to permeant disability. In the early stage of MS, inflammation i
Autor:
Noel Marie-France Thomsen, Simone Bonazzi, Stephanie M. McTighe, Guiqing Liang, Danuta Lubicka, Sarah Salas, Jill Nunez, Franco Lombardo, Rajeshri Ganesh Karki, Audrey Gray, Stefan Peukert, Doug Burdette, Jean-Cosme Dodart, Leon Murphy, Grazia Piizzi, Carleton Goold, Labbe-Giguere Nancy, Erin P. Keaney, Jonathan D. Biag, Christine D. Wilson, Aakruti Gorde, Lawrence G. Hamann, Yingchuan Sun, Lin Deng, Hasnain A. Malik, Daniel Curtis, Shanming Liu
Publikováno v:
Journal of medicinal chemistry. 63(3)
Recent clinical evaluation of everolimus for seizure reduction in patients with tuberous sclerosis complex (TSC), a disease with overactivated mechanistic target of rapamycin (mTOR) signaling, has demonstrated the therapeutic value of mTOR inhibitors
Publikováno v:
Drug Metabolism and Pharmacokinetics. 35:S23-S24
Autor:
Jashvant D. Unadkat, Bhagwat Prasad, Guangqing Xiao, Raymond Evers, W. Griffith Humphreys, Christopher Rowbottom, Cornelis E. C. A. Hop, Doug Burdette, Xiaoyan Chu, Tot Bui Nguyen, Yurong Lai, Laurent Salphati, Sarah Billington
Publikováno v:
Clinical pharmacology and therapeutics. 106(1)
For in vitro to in vivo extrapolation (IVIVE) of brain distribution of drugs that are transported at the human blood-brain barrier (BBB), it is important to quantify the interindividual and regional variability of drug transporter abundance at this b
Autor:
Alicia Pietrasiewicz, Taras Tuczkewycz, Sudarshan Kapadnis, Richard Grater, Christopher Rowbottom, Daniel Qiu, Doug Burdette, Elvana Viezaj
Publikováno v:
Drug Metabolism and Pharmacokinetics. 35:S62
Autor:
Hilkka I. Kenttämaa, Ryan J. Eismin, Minli Zhang, Ye Wu, Rebecca Urbanek, Doug Burdette, Hui Xiong
Publikováno v:
Drug Metabolism and Disposition. 43:358-366
2-Aminothiazolobenzazepine (2-ATBA), 7-[(1-methyl-1H-pyrazol-4-yl)methyl]-6,7,8,9-tetrahydro-5H-[1,3]thiazolo[4,5-h][3]benzazepin-2-amine, is a D2 partial agonist that has demonstrated antipsychotic effects in a rodent in vivo efficacy model. The met
Publikováno v:
Drug Metabolism and Disposition. 39:302-311
Studies on the biotransformation of isoxazole rings have shown that molecules containing a C3-substituted isoxazole or a 1,2-benzisoxazole can undergo a two-electron reductive ring cleavage to form an imine. In the absence of a C3 substituent, the is
Publikováno v:
Drug Metabolism and Disposition. 38:1767-1778
Multiple GSH adducts of the oxidative products of nomifensine (M1-M9) in human hepatocytes and liver microsomes have been identified recently. The current study reports three new types of monooxygenated metabolites of nomifensine identified in human
Publikováno v:
Drug Metabolism and Disposition. 38:46-60
8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline maleate (nomifensine), an antidepressant drug, was withdrawn from the market because of increased incidence of hemolytic anemia, as well as kidney and liver toxicity. Although the nature of the