Výsledky vyhledávání - "Doug A Brooks"

Akademický článek

Low dose aspirin prevents endothelial dysfunction in the aorta and foetal loss in pregnant mice infected with influenza A virus

Autor: Madison Coward-Smith, Stella Liong, Osezua Oseghale, Jonathan R. Erlich, Mark A. Miles, Felicia Liong, Kurt Brassington, Steven Bozinovski, Ross Vlahos, Robert D. Brooks, Doug A. Brooks, John J. O’Leary, Stavros Selemidis

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

Influenza A virus (IAV) infection in pregnancy resembles a preeclamptic phenotype characterised by vascular dysfunction and foetal growth retardation. Given that low dose aspirin (ASA) is safe in pregnancy and is used to prevent preeclampsia, we inve

Externí odkaz: https://doaj.org/article/3fc0146337bf43658a35e6dc48143063

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Akademický článek

Ex vivo expansion of circulating tumour cells (CTCs)

Autor: Bashir M. Mohamed, Mark P. Ward, Mark Bates, Cathy D. Spillane, Tanya Kelly, Cara Martin, Michael Gallagher, Sheena Heffernan, Lucy Norris, John Kennedy, Feras Abu Saadeh, Noreen Gleeson, Doug A. Brooks, Robert D. Brooks, Stavros Selemidis, Sharon O’Toole, John J. O’Leary

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)

Abstract Circulating tumour cells (CTCs) are a critical intermediate step in the process of cancer metastasis. The reliability of CTC isolation/purification has limited both the potential to report on metastatic progression and the development of CTC

Externí odkaz: https://doaj.org/article/8a0eceb23e854e889f86fef99c3b1ed3

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Akademický článek

TLR7 promotes chronic airway disease in RSV-infected mice

Autor: Mark A. Miles, Stella Liong, Felicia Liong, Madison Coward-Smith, Gemma S. Trollope, Osezua Oseghale, Jonathan R. Erlich, Robert D. Brooks, Jessica M. Logan, Shane Hickey, Hao Wang, Steven Bozinovski, John J. O’Leary, Doug A. Brooks, Stavros Selemidis

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Respiratory syncytial virus (RSV) commonly infects the upper respiratory tract (URT) of humans, manifesting with mild cold or flu-like symptoms. However, in infants and the elderly, severe disease of the lower respiratory tract (LRT) often occurs and

Externí odkaz: https://doaj.org/article/e057fb9f2c4a48098536263b49a04f2f

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Akademický článek

TLR9 Monotherapy in Immune-Competent Mice Suppresses Orthotopic Prostate Tumor Development

Autor: Mark A. Miles, Raymond Luong, Eunice E. To, Jonathan R. Erlich, Stella Liong, Felicia Liong, Jessica M. Logan, John O’Leary, Doug A. Brooks, Stavros Selemidis

Publikováno v: Cells, Vol 13, Iss 1, p 97 (2024)

Prostate cancer is ranked second in the world for cancer-related deaths in men, highlighting the lack of effective therapies for advanced-stage disease. Toll-like receptors (TLRs) and immunity have a direct role in prostate cancer pathogenesis, but T

Externí odkaz: https://doaj.org/article/61917abee6a14a65a0c6708159efdbcf

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Akademický článek

Therapeutic Targeting of Endosome and Mitochondrial Reactive Oxygen Species Protects Mice From Influenza Virus Morbidity

Autor: Eunice E. To, Jonathan R. Erlich, Felicia Liong, Stella Liong, Raymond Luong, Osezua Oseghale, Mark A. Miles, Paris C. Papagianis, Kylie M. Quinn, Steven Bozinovski, Ross Vlahos, Robert D. Brooks, John J. O’Leary, Doug A. Brooks, Stavros Selemidis

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

There is an urgent need to develop effective therapeutic strategies including immunomodulators to combat influenza A virus (IAV) infection. Influenza A viruses increase ROS production, which suppress anti-viral responses and contribute to pathologica

Externí odkaz: https://doaj.org/article/a98e506ed5024879a44e694c00bb87b9

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Akademický článek

Influenza Virus Infection during Pregnancy as a Trigger of Acute and Chronic Complications

Autor: Osezua Oseghale, Ross Vlahos, John J. O’Leary, Robert D. Brooks, Doug A. Brooks, Stella Liong, Stavros Selemidis

Publikováno v: Viruses, Vol 14, Iss 12, p 2729 (2022)

Influenza A virus (IAV) infection during pregnancy disrupts maternal and fetal health through biological mechanisms, which are to date poorly characterised. During pregnancy, the viral clearance mechanisms from the lung are sub-optimal and involve hy

Externí odkaz: https://doaj.org/article/eefc3e35ffb24c8fb47a010b18d1df82

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Akademický článek

Glycolysis and the Pentose Phosphate Pathway Promote LPS-Induced NOX2 Oxidase- and IFN-β-Dependent Inflammation in Macrophages

Autor: Jonathan R. Erlich, Eunice E. To, Raymond Luong, Felicia Liong, Stella Liong, Osezua Oseghale, Mark A. Miles, Steven Bozinovski, Robert D. Brooks, Ross Vlahos, Stanley Chan, John J. O’Leary, Doug A. Brooks, Stavros Selemidis

Publikováno v: Antioxidants, Vol 11, Iss 8, p 1488 (2022)

Macrophages undergo a metabolic switch from oxidative phosphorylation to glycolysis when exposed to gram-negative bacterial lipopolysaccharide (LPS), which modulates antibacterial host defence mechanisms. Here, we show that LPS treatment of macrophag

Externí odkaz: https://doaj.org/article/83b0f2bd21c8471894b47e8cff871b29

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Akademický článek

Identification of Novel miRNAs Involved in Cardiac Repair Following Infarction in Fetal and Adolescent Sheep Hearts

Autor: Mitchell C. Lock, Ross L. Tellam, Jack R. T. Darby, Jia Yin Soo, Doug A. Brooks, Mike Seed, Joseph B. Selvanayagam, Janna L. Morrison

Publikováno v: Frontiers in Physiology, Vol 11 (2020)

AimsAnimal models have been used to show that there are critical molecular mechanisms that can be activated to induce myocardial repair at specific times in development. For example, specific miRNAs are critical for regulating the response to myocard

Externí odkaz: https://doaj.org/article/216866ef0c1f406893f32f76643d5263

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