Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Doug, Falls"'
Autor:
Mathew M. Mulhern, Yau Yi Lau, Hing L. Sham, Zhi Su, Gang Zhao, Brian A. Droz, Xiaojun Wang, Kennan C. Marsh, Seble Wagaw, Christine A. Collins, Jennifer L. Freeman, Michael E. Brune, Nelson Grihalde, Rajesh R. Iyengar, Kenneth M. Engstrom, Gilbert Diaz, Regina M. Reilly, Lynch John K, Matthew M. Ravn, David W A Beno, Philip R. Kym, Ju Gao, Sevan Brodjian, H. Doug Falls, Brian D. Dayton, Martin J. Voorbach, Dennis G Fry, Andrew J. Souers, Andrew S. Judd
Publikováno v:
Journal of medicinal chemistry. 51(3)
A highly potent and selective DGAT-1 inhibitor was identified and used in rodent models of obesity and postprandial chylomicron excursion to validate DGAT-1 inhibition as a novel approach for the treatment of metabolic diseases. Specifically, compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c61d8d74e1723130c95fb0f63edbf2df
https://pubmed.ncbi.nlm.nih.gov/18183944
https://pubmed.ncbi.nlm.nih.gov/18183944
Autor:
Ruth L. Martin, Andrew S. Judd, Sevan Brodjian, Dariusz Wodka, Gilbert Diaz, Lynch John K, Philip R. Kym, Sandra Leitza, Hing L. Sham, Freeman Jennifer C, Mathew M. Mulhern, Gang Zhao, Andrew J. Souers, Christine A. Collins, Sue Swanson, Brian D. Dayton, Rajesh R. Iyengar, Kathryn Houseman, Regina M. Reilly, H. Doug Falls, Ju Gao, Zhi Su
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(4)
The optimization of potent MCHr1 antagonist 1 with respect to improving its in vitro profile by replacement of the 3,4-methylenedioxy phenyl (piperonyl) moiety led to the discovery of 19, a compound that showed excellent MCHr1 binding and functional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da59a1aec9dcf44b88c4d0066d18ebcd
https://pubmed.ncbi.nlm.nih.gov/17234405
https://pubmed.ncbi.nlm.nih.gov/17234405
Autor:
Dariusz Wodka, David W A Beno, Rajesh R. Iyengar, Kennan C. Marsh, Freeman Jennifer C, Michael E. Brune, Lynch John K, James J. Napier, Brian D. Dayton, Andrew S. Judd, Regina M. Reilly, Gilbert Diaz, Mathew M. Mulhern, H. Doug Falls, Chong J. Chen, Andrew J. Souers, Gang Zhao, Brian A. Droz, Philip R. Kym, Christine A. Collins, Lisa E. Hernandez, Ju Gao, Eugene N. Bush, Hing L. Sham, Victoria Knourek-Segel, Sevan Brodjian, Robin Shapiro
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(4)
The incorporation of constrained tertiary amines into an existing class of N-benzyl-4-aminopiperidinyl chromone-based MCHr1 antagonists led to the identification of a series of chiral racemic compounds that displayed good to excellent functional pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5521fb8d892849699b9685c0e7e09a09
https://pubmed.ncbi.nlm.nih.gov/17188866
https://pubmed.ncbi.nlm.nih.gov/17188866
Autor:
Iyengar, Rajesh R., Lynch, John K., Mulhern, Mathew M., Judd, Andrew S., Freeman, Jennifer C., Gao, Ju, Souers, Andrew J., Zhao, Gang, Wodka, Dariusz, Doug Falls, H., Brodjian, Sevan, Dayton, Brian D., Reilly, Regina M., Swanson, Sue, Su, Zhi, Martin, Ruth L., Leitza, Sandra T., Houseman, Kathryn A., Diaz, Gilbert, Collins, Christine A., Sham, Hing L., Kym, Philip R.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 2007 17(4):874-878
Autor:
Gang Zhao, Martin Voorbach, H. Doug Falls, Brian Droz, Sevan Brodjian, Yau Yi Lau, Rajesh R. Iyengar, Ju Gao, Andrew S. Judd, Seble H. Wagaw, Matthew M. Ravn, Kenneth M. Engstrom, John K. Lynch, Mathew M. Mulhern, Jennifer Freeman, Brian D. Dayton, Xiaojun Wang, Nelson Grihalde, Dennis Fry, David W. A. Beno
Publikováno v:
Journal of Medicinal Chemistry; Jan2008, Vol. 51 Issue 3, p380-383, 4p
Autor:
Wel, Lin Chun, Masaki, Nakane, Mike, Stashko, Doug, Falls, Jane, Kuk, Loan, Miller, Ruth, Huang, Curtis, Tyree, N, Miner Jeffrey, John, Rosen, R, Kym Philip, J, Coghlan Mike, George, Carter, C, Lane Ben
Publikováno v:
Molecular Pharmacology; August 2002, Vol. 62 Issue: 2 p297-303, 7p