Zobrazeno 1 - 10
of 2 032
pro vyhledávání: '"Douek P"'
Variant-proof high affinity ACE2 antagonist limits SARS-CoV-2 replication in upper and lower airways
Autor:
Matthew Gagne, Barbara J. Flynn, Christopher Cole Honeycutt, Dillon R. Flebbe, Shayne F. Andrew, Samantha J. Provost, Lauren McCormick, Alex Van Ry, Elizabeth McCarthy, John-Paul M. Todd, Saran Bao, I-Ting Teng, Shir Marciano, Yinon Rudich, Chunlin Li, Shilpi Jain, Bushra Wali, Laurent Pessaint, Alan Dodson, Anthony Cook, Mark G. Lewis, Hanne Andersen, Jiří Zahradník, Mehul S. Suthar, Martha C. Nason, Kathryn E. Foulds, Peter D. Kwong, Mario Roederer, Gideon Schreiber, Robert A. Seder, Daniel C. Douek
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract SARS-CoV-2 has the capacity to evolve mutations that escape vaccine- and infection-acquired immunity and antiviral drugs. A variant-agnostic therapeutic agent that protects against severe disease without putting selective pressure on the vir
Externí odkaz:
https://doaj.org/article/398a2dfd9ac6483f881f1a81f6f17840
Autor:
Jason Gorman, Crystal Sao-Fong Cheung, Zhijian Duan, Li Ou, Maple Wang, Xuejun Chen, Cheng Cheng, Andrea Biju, Yaping Sun, Pengfei Wang, Yongping Yang, Baoshan Zhang, Jeffrey C. Boyington, Tatsiana Bylund, Sam Charaf, Steven J. Chen, Haijuan Du, Amy R. Henry, Tracy Liu, Edward K. Sarfo, Chaim A. Schramm, Chen-Hsiang Shen, Tyler Stephens, I-Ting Teng, John-Paul Todd, Yaroslav Tsybovsky, Raffaello Verardi, Danyi Wang, Shuishu Wang, Zhantong Wang, Cheng-Yan Zheng, Tongqing Zhou, Daniel C. Douek, John R. Mascola, David D. Ho, Mitchell Ho, Peter D. Kwong
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Lassa virus (LASV) infection is expanding outside its traditionally endemic areas in West Africa, posing a pandemic biothreat. LASV-neutralizing antibodies, moreover, have proven difficult to elicit. To gain insight into LASV neutralization,
Externí odkaz:
https://doaj.org/article/83f13599c74f445ebfcd24f0985fef96
Autor:
Chaim A. Schramm, Damee Moon, Lowrey Peyton, Noemia S. Lima, Christian Wake, Kristin L. Boswell, Amy R. Henry, Farida Laboune, David Ambrozak, Samuel W. Darko, I-Ting Teng, Kathryn E. Foulds, Andrea Carfi, Darin K. Edwards, Peter D. Kwong, Richard A. Koup, Robert A. Seder, Daniel C. Douek
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract As SARS-CoV-2 variants continue evolving, testing updated vaccines in non-human primates remains important for guiding human clinical practice. To date, such studies have focused on antibody titers and antigen-specific B and T cell frequenci
Externí odkaz:
https://doaj.org/article/5c17ee640e21465b8f13ef277281b87f
Autor:
Hai Nguyen-Tran, Alicen B. Spaulding, Kevin Messacar, Matthew R. Vogt, Perdita Permaul, Daniel C. Douek, Abe Mittelman, Careese Thompson, Sandy Grubbs, Christine Magana, Michelle L. Hernandez
Publikováno v:
Contemporary Clinical Trials Communications, Vol 41, Iss , Pp 101351- (2024)
Recruitment and retention are challenges for prospective pediatric cohort studies, particularly those involving serial venipunctures. We investigated factors underlying enrollment and retention in the Pandemic Response Repository through Microbial an
Externí odkaz:
https://doaj.org/article/f9adc2d5ad3641468473023c275c2978
Publikováno v:
Pathogens and Immunity, Vol 9, Iss 1 (2024)
It is widely acknowledged that HIV infection results in disruption of the gut’s mucosal integrity partly due a profound loss of gastrointestinal CD4+ T cells that are targets of the virus. In addition, systemic inflammation and immune activation th
Externí odkaz:
https://doaj.org/article/5d948931ec8a4ec8ade62933c20a8b4a
Autor:
Sang Woo Park, Kevin Messacar, Daniel C. Douek, Alicen B. Spaulding, C. Jessica E. Metcalf, Bryan T. Grenfell
Publikováno v:
Epidemics, Vol 46, Iss , Pp 100736- (2024)
Recent outbreaks of enterovirus D68 (EV-D68) infections, and their causal linkage with acute flaccid myelitis (AFM), continue to pose a serious public health concern. During 2020 and 2021, the dynamics of EV-D68 and other pathogens have been signific
Externí odkaz:
https://doaj.org/article/d8304b757a3a49cd8546a22a0c838893
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Humans have intensively sailed the Mediterranean and European Atlantic waters throughout history, from the upper Paleolithic until today and centuries of human seafaring have established complex coastal and cross-seas navigation networks. Hi
Externí odkaz:
https://doaj.org/article/c6eb0a4011964be38c26183d94b747ef
Autor:
Erlich, Yaniv, Douek, Daniel
SARS-CoV-2 is the third betacoronavirus to enter the human population in the past 20 years, revealing a concerning pattern. Clearly, preventing a future pandemic from such viruses is a critical priority. Previous studies have shown that shRNAs can be
Externí odkaz:
http://arxiv.org/abs/2107.01208
Autor:
Kalani Ratnasiri, Hong Zheng, Jiaying Toh, Zhiyuan Yao, Veronica Duran, Michele Donato, Mario Roederer, Megha Kamath, John-Paul M. Todd, Matthew Gagne, Kathryn E. Foulds, Joseph R. Francica, Kizzmekia S. Corbett, Daniel C. Douek, Robert A. Seder, Shirit Einav, Catherine A. Blish, Purvesh Khatri
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113706- (2024)
Summary: Viral pandemics and epidemics pose a significant global threat. While macaque models of viral disease are routinely used, it remains unclear how conserved antiviral responses are between macaques and humans. Therefore, we conducted a cross-s
Externí odkaz:
https://doaj.org/article/be8e0d27559e4d5bb6abb11d7c732b41
Publikováno v:
Canadian Jewish Studies, Vol 36 (2024)
Externí odkaz:
https://doaj.org/article/58b3407d28404deea154a7f099372b40