Antiretroviral Drug Repositioning for Glioblastoma.

Autor: Rivas SR; Surgical Neurology Branch, National Institute of Neurological Diseases and Stroke, Bethesda, MD 20892, USA.; Section of Virology and Immunotherapy, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA., Mendez Valdez MJ; Section of Virology and Immunotherapy, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA., Chandar JS; Section of Virology and Immunotherapy, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA., Desgraves JF; Section of Virology and Immunotherapy, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA., Lu VM; Section of Virology and Immunotherapy, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA., Ampie L; Surgical Neurology Branch, National Institute of Neurological Diseases and Stroke, Bethesda, MD 20892, USA., Singh EB; Section of Virology and Immunotherapy, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA., Seetharam D; Section of Virology and Immunotherapy, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA., Ramsoomair CK; Section of Virology and Immunotherapy, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA., Hudson A; Section of Virology and Immunotherapy, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA., Ingle SM; Section of Virology and Immunotherapy, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA., Govindarajan V; Section of Virology and Immunotherapy, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA., Doucet-O'Hare TT; Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA., DeMarino C; Surgical Neurology Branch, National Institute of Neurological Diseases and Stroke, Bethesda, MD 20892, USA., Heiss JD; Surgical Neurology Branch, National Institute of Neurological Diseases and Stroke, Bethesda, MD 20892, USA., Nath A; Surgical Neurology Branch, National Institute of Neurological Diseases and Stroke, Bethesda, MD 20892, USA., Shah AH; Section of Virology and Immunotherapy, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

Publikováno v: Cancers [Cancers (Basel)] 2024 Apr 30; Vol. 16 (9). Date of Electronic Publication: 2024 Apr 30.

Human endogenous retrovirus K contributes to a stem cell niche in glioblastoma.

Autor: Shah AH; University of Miami School of Medicine, Department of Neurosurgery, Miami, Florida, USA., Rivas SR; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, USA., Doucet-O'Hare TT; Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA., Govindarajan V; University of Miami School of Medicine, Department of Neurosurgery, Miami, Florida, USA., DeMarino C; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, USA., Wang T; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, USA., Ampie L; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, USA., Zhang Y; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, USA., Banasavadi-Siddegowda YK; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, USA., Walbridge S; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, USA., Maric D; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, USA., Garcia-Montojo M; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, USA., Suter RK; Georgetown University, Bioinformatics Section, Washington, DC, USA., Lee MH; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, USA., Zaghloul KA; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, USA., Steiner J; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, USA., Elkahloun AG; Cancer Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, USA., Chandar J; University of Miami School of Medicine, Department of Neurosurgery, Miami, Florida, USA., Seetharam D; University of Miami School of Medicine, Department of Neurosurgery, Miami, Florida, USA., Desgraves J; University of Miami School of Medicine, Department of Neurosurgery, Miami, Florida, USA., Li W; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, USA., Johnson K; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, USA., Ivan ME; University of Miami School of Medicine, Department of Neurosurgery, Miami, Florida, USA., Komotar RJ; University of Miami School of Medicine, Department of Neurosurgery, Miami, Florida, USA., Gilbert MR; Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA., Heiss JD; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, USA., Nath A; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, USA.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2023 Jul 03; Vol. 133 (13). Date of Electronic Publication: 2023 Jul 03.

The Role of HERV-K in Cancer Stemness.

Autor: Rivas SR; Surgical Neurology Branch, National Institute of Neurological Diseases and Stroke, Bethesda, MD 20892, USA., Valdez MJM; Section of Virology and Immunotherapy, Department of Neurosurgery, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Govindarajan V; Section of Virology and Immunotherapy, Department of Neurosurgery, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Seetharam D; Section of Virology and Immunotherapy, Department of Neurosurgery, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Doucet-O'Hare TT; Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA., Heiss JD; Surgical Neurology Branch, National Institute of Neurological Diseases and Stroke, Bethesda, MD 20892, USA., Shah AH; Section of Virology and Immunotherapy, Department of Neurosurgery, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA.

Publikováno v: Viruses [Viruses] 2022 Sep 12; Vol. 14 (9). Date of Electronic Publication: 2022 Sep 12.

A multiparametric pharmacogenomic strategy for drug repositioning predicts therapeutic efficacy for glioblastoma cell lines.

Autor: Shah AH; Department of Neurological Surgery, Sylvester Comprehensive Cancer Center, Miami, Florida, USA., Suter R; Department of Neurological Surgery, Sylvester Comprehensive Cancer Center, Miami, Florida, USA., Gudoor P; Department of Neurological Surgery, Sylvester Comprehensive Cancer Center, Miami, Florida, USA., Doucet-O'Hare TT; Neuro-Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA., Stathias V; Department of Molecular and Cellular Pharmacology, University of Miami, Miami, Florida, USA., Cajigas I; Department of Neurological Surgery, Sylvester Comprehensive Cancer Center, Miami, Florida, USA., de la Fuente M; Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA., Govindarajan V; Department of Neurological Surgery, Sylvester Comprehensive Cancer Center, Miami, Florida, USA., Morell AA; Department of Neurological Surgery, Sylvester Comprehensive Cancer Center, Miami, Florida, USA., Eichberg DG; Department of Neurological Surgery, Sylvester Comprehensive Cancer Center, Miami, Florida, USA., Luther E; Department of Neurological Surgery, Sylvester Comprehensive Cancer Center, Miami, Florida, USA., Lu VM; Department of Neurological Surgery, Sylvester Comprehensive Cancer Center, Miami, Florida, USA., Heiss J; Surgical Neurology Division, NINDS National Institute of Health, Bethesda, Maryland, USA., Komotar RJ; Department of Neurological Surgery, Sylvester Comprehensive Cancer Center, Miami, Florida, USA., Ivan ME; Department of Neurological Surgery, Sylvester Comprehensive Cancer Center, Miami, Florida, USA., Schurer S; Department of Neurological Surgery, Sylvester Comprehensive Cancer Center, Miami, Florida, USA., Gilbert MR; Neuro-Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA., Ayad NG; Department of Neurological Surgery, Sylvester Comprehensive Cancer Center, Miami, Florida, USA.

Publikováno v: Neuro-oncology advances [Neurooncol Adv] 2021 Dec 31; Vol. 4 (1), pp. vdab192. Date of Electronic Publication: 2021 Dec 31 (Print Publication: 2022).

SMARCB1 deletion in atypical teratoid rhabdoid tumors results in human endogenous retrovirus K (HML-2) expression.

Autor: Doucet-O'Hare TT; Section of Infection of the Nervous System, Disorders and Stroke (NINDS), National Institute of Neurological, National Institutes of Health (NIH), Bldg 10; Room 7C-103; 10 Center Drive, Bethesda, MD, 20892, USA., DiSanza BL; Section of Infection of the Nervous System, Disorders and Stroke (NINDS), National Institute of Neurological, National Institutes of Health (NIH), Bldg 10; Room 7C-103; 10 Center Drive, Bethesda, MD, 20892, USA., DeMarino C; Section of Infection of the Nervous System, Disorders and Stroke (NINDS), National Institute of Neurological, National Institutes of Health (NIH), Bldg 10; Room 7C-103; 10 Center Drive, Bethesda, MD, 20892, USA., Atkinson AL; Section of Infection of the Nervous System, Disorders and Stroke (NINDS), National Institute of Neurological, National Institutes of Health (NIH), Bldg 10; Room 7C-103; 10 Center Drive, Bethesda, MD, 20892, USA., Rosenblum JS; Neuro-Oncology Branch, National Cancer Institute (NCI), Bethesda, USA., Henderson LJ; Section of Infection of the Nervous System, Disorders and Stroke (NINDS), National Institute of Neurological, National Institutes of Health (NIH), Bldg 10; Room 7C-103; 10 Center Drive, Bethesda, MD, 20892, USA., Johnson KR; Bioinformatics Section, National Institute of Neurological Disorders and Stroke, Bethesda, USA., Kowalak J; Clinical Proteomics Unit, National Cancer Institute (NCI), Bethesda, USA., Garcia-Montojo M; Section of Infection of the Nervous System, Disorders and Stroke (NINDS), National Institute of Neurological, National Institutes of Health (NIH), Bldg 10; Room 7C-103; 10 Center Drive, Bethesda, MD, 20892, USA., Allen SJ; Department of Pathology, St. Jude's Children's Research Hospital, Memphis, USA., Orr BA; Department of Pathology, St. Jude's Children's Research Hospital, Memphis, USA., Santi M; Department of Pathology, Perelman School of Medicine, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA., Wang T; Neural Differentiation Unit, Translational Neuroscience Center, NINDS, Bethesda, NIHMD, USA., Fathi S; Section of Infection of the Nervous System, Disorders and Stroke (NINDS), National Institute of Neurological, National Institutes of Health (NIH), Bldg 10; Room 7C-103; 10 Center Drive, Bethesda, MD, 20892, USA., Lee MH; Section of Infection of the Nervous System, Disorders and Stroke (NINDS), National Institute of Neurological, National Institutes of Health (NIH), Bldg 10; Room 7C-103; 10 Center Drive, Bethesda, MD, 20892, USA., Sampson K; Section of Infection of the Nervous System, Disorders and Stroke (NINDS), National Institute of Neurological, National Institutes of Health (NIH), Bldg 10; Room 7C-103; 10 Center Drive, Bethesda, MD, 20892, USA., Li W; Section of Infection of the Nervous System, Disorders and Stroke (NINDS), National Institute of Neurological, National Institutes of Health (NIH), Bldg 10; Room 7C-103; 10 Center Drive, Bethesda, MD, 20892, USA., Zhuang Z; Neuro-Oncology Branch, National Cancer Institute (NCI), Bethesda, USA., Nath A; Section of Infection of the Nervous System, Disorders and Stroke (NINDS), National Institute of Neurological, National Institutes of Health (NIH), Bldg 10; Room 7C-103; 10 Center Drive, Bethesda, MD, 20892, USA. Avindra.nath@nih.gov.

Publikováno v: Scientific reports [Sci Rep] 2021 Jun 18; Vol. 11 (1), pp. 12893. Date of Electronic Publication: 2021 Jun 18.