Zobrazeno 1 - 10
of 3 884
pro vyhledávání: '"Double-strand break repair"'
Publikováno v:
Успехи молекулярной онкологии, Vol 11, Iss 3, Pp 8-23 (2024)
Disruption of mechanisms that maintain genome stability is an essential factor of tumor progression. Accordingly, predisposition to the development of neoplasms is often associated with germline mutations in genes involved in DNA damage detection and
Externí odkaz:
https://doaj.org/article/5e40f409f8c042eaabb4eac49d3d4a98
Publikováno v:
Neurobiology of Disease, Vol 201, Iss , Pp 106675- (2024)
α-synuclein (αSyn) is a presynaptic and nuclear protein that aggregates in important neurodegenerative diseases such as Parkinson's Disease (PD), Parkinson's Disease Dementia (PDD) and Lewy Body Dementia (LBD). Our past work suggests that nuclear
Externí odkaz:
https://doaj.org/article/21878170bbf543eb8878f2c707f5951b
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background Inherited variations in DNA double-strand break (DSB) repair pathway are known to influence ovarian cancer occurrence, progression and treatment response. Despite its significance, survival-associated genetic variants within the D
Externí odkaz:
https://doaj.org/article/44b311a2d8f540fdb61b03090e943cce
Publikováno v:
Frontiers in Epigenetics and Epigenomics, Vol 2 (2024)
Histone post-translational modifications and variants play crucial roles in the adaptability of chromatin structure, facilitating rapid responses necessary for biological processes such as transcription, replication, and DNA damage signaling. Notably
Externí odkaz:
https://doaj.org/article/e82cdfecb18a40bd8dd8a5c462e1c11b
Autor:
Mingyang Li, Genbao Shao
Publikováno v:
Antioxidants, Vol 13, Iss 11, p 1337 (2024)
Oxidative stress, driven by reactive oxygen species (ROS) such as hydrogen peroxide (H2O2), induces DNA double-strand breaks (DSBs) that compromise genomic integrity. The DNA Damage Response (DDR), primarily mediated by ATM and ATR kinases, is crucia
Externí odkaz:
https://doaj.org/article/4a3a3576e52f443cbe3da40b2db3e55a
The role of DNA double-strand break repair defects in the pathogenesis of neurodegenerative diseases
Publikováno v:
生物医学转化, Vol 4, Iss 2, Pp 31-41 (2023)
DNA double-strand break repair (DSBR) plays an important role in maintaining genome stability and cell survival. DSBR are predominately accomplished by two pathways: Homologous Recombination (HR) and Non-homologous End Joining (NHEJ), and both pathwa
Externí odkaz:
https://doaj.org/article/c4f19ad5c06f4bbbb8c4ed9ced05a093
Publikováno v:
Cancer Biology & Therapy, Vol 24, Iss 1 (2023)
Hepatocellular carcinoma (HCC) is one of the most common types of malignant tumors with increasing incidence rates and high mortality rates. The currently available methods for treating HCC include surgery, radiotherapy or chemotherapy, but all of th
Externí odkaz:
https://doaj.org/article/355daf3ee6844353ae498d5642c1ee3a
Autor:
Chiaki Kinoshita, Yoshimasa Takizawa, Mika Saotome, Shun Ogino, Hitoshi Kurumizaka, Wataru Kagawa
Publikováno v:
FEBS Open Bio, Vol 13, Iss 3, Pp 408-418 (2023)
The human RAD52 protein, which forms an oligomeric ring structure, is involved in DNA double‐strand break repair. The N‐terminal half of RAD52 is primarily responsible for self‐oligomerisation and DNA binding. Crystallographic studies have reve
Externí odkaz:
https://doaj.org/article/b7da9833a3ae4018be877cbb8df200dd
Autor:
Olsen MB, Huse C, Sousa MMLD, Murphy SL, Sarno A, Obermann TS, Yang K, Holter JC, Jørgensen MJ, Christensen EE, Wang W, Ji P, Heggelund L, Hoel H, Dyrhol-Riise AM, Gregersen I, Aukrust P, Bjørås M, Halvorsen B, Dahl TB
Publikováno v:
Journal of Inflammation Research, Vol Volume 15, Pp 6629-6644 (2022)
Maria Belland Olsen,1,2 Camilla Huse,1,2 Mirta Mittelstedt Leal de Sousa,3,4 Sarah Louise Murphy,1,2 Antonio Sarno,3,5 Tobias Sebastian Obermann,3 Kuan Yang,1 Jan Cato Holter,2,6 Marte Jøntvedt Jørgensen,2,7 Erik Egeland Christensen,2,7 Wei Wang,3
Externí odkaz:
https://doaj.org/article/f13c0e2d10f345eaabdb17061ea53946
Autor:
Nadia Vertti-Quintero, Ethan Levien, Lucie Poggi, Ariel Amir, Guy-Franck Richard, Charles N. Baroud
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-17 (2022)
Abstract Background Double-strand break repair (DSBR) is a highly regulated process involving dozens of proteins acting in a defined order to repair a DNA lesion that is fatal for any living cell. Model organisms such as Saccharomyces cerevisiae have
Externí odkaz:
https://doaj.org/article/cc8a768518374721880ab711674c5086