Zobrazeno 1 - 10
of 276
pro vyhledávání: '"Double stranded RNA (dsRNA)"'
Publikováno v:
RNA Biology, Vol 21, Iss 1, Pp 1128-1145 (2024)
The process of adenosine deaminase (ADAR)-catalyzed double-stranded RNA (dsRNA) Adenosine-to-Inosine (A-to-I) editing is essential for the correction of pathogenic mutagenesis, as well as the regulation of gene expression and protein function in mamm
Externí odkaz:
https://doaj.org/article/4a1b72ecf5134bf284860c9dc7d95ab4
Autor:
Robin Lenk, Werner Kleindienst, Gábor Tamás Szabó, Markus Baiersdörfer, Gábor Boros, Jason M. Keller, Azita J. Mahiny, Irena Vlatkovic
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
The success of messenger (m)RNA-based vaccines against SARS-CoV-2 during the COVID-19 pandemic has led to rapid growth and innovation in the field of mRNA-based therapeutics. However, mRNA production, whether in small amounts for research or large-sc
Externí odkaz:
https://doaj.org/article/6215054dbc15478d878da43bdd41b024
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Background In all organisms, the innate immune system defends against pathogens through basal expression of molecules that provide critical barriers to invasion and inducible expression of effectors that combat infection. The adenosine deami
Externí odkaz:
https://doaj.org/article/a704ed3a390c4da78923190a8ad2a70a
Autor:
Carlos F. Estevez-Castro, Murillo F. Rodrigues, Antinéa Babarit, Flávia V. Ferreira, Elisa G. de Andrade, Eric Marois, Rodrigo Cogni, Eric R. G. R. Aguiar, João T. Marques, Roenick P. Olmo
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-20 (2024)
Abstract Background Mosquito borne viruses, such as dengue, Zika, yellow fever and Chikungunya, cause millions of infections every year. These viruses are mostly transmitted by two urban-adapted mosquito species, Aedes aegypti and Aedes albopictus. A
Externí odkaz:
https://doaj.org/article/ee5a87bf4bc848d481097ff4e59ad9ab
Publikováno v:
Tikrit Journal for Agricultural Sciences, Vol 24, Iss 2 (2024)
The hypothesized role of stress-inducible heat shock proteins is to act as a buffer against environmental variations and affect fitness in suboptimal conditions. Our study examining the functions of heat shock protein 27 (Hsp27) in the eggs of the Me
Externí odkaz:
https://doaj.org/article/752da213c398475f95fded6318b84275
Autor:
Dharia Sara Silas, Bindiya Juneja, Keerat Kaur, Muralikrishna Narayanareddy Gari, Yingjian You, Youmi Moon, Yizhuo Chen, Srishti Arora, Johanna Hansen, Kathir Muthusamy, Yue Fu, Nisha Palackal, Erica A. Pyles
Publikováno v:
Pharmaceutics, Vol 16, Iss 9, p 1227 (2024)
Background: In vitro-transcribed (IVT) mRNA has been established as a promising platform for therapeutics and vaccine development. Double-stranded RNA (dsRNA) is a major impurity of IVT mRNA and can trigger unfavored immune responses, potentially cau
Externí odkaz:
https://doaj.org/article/3c9a6241abe84136aea0e57880826076
Publikováno v:
RNA Biology, Vol 19, Iss 1, Pp 841-851 (2022)
Germline-encoded pattern recognition receptors [PRRs] in mammalian cells function in the detection of molecular patterns associated with pathogen invasion or cellular damage. A PRR subset is activated by the atypical presence and location of double-s
Externí odkaz:
https://doaj.org/article/f32e651f511045e4b32efa355397da89
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