Zobrazeno 1 - 10
of 9 143
pro vyhledávání: '"Double strand break"'
Publikováno v:
Успехи молекулярной онкологии, Vol 11, Iss 3, Pp 8-23 (2024)
Disruption of mechanisms that maintain genome stability is an essential factor of tumor progression. Accordingly, predisposition to the development of neoplasms is often associated with germline mutations in genes involved in DNA damage detection and
Externí odkaz:
https://doaj.org/article/5e40f409f8c042eaabb4eac49d3d4a98
Publikováno v:
Aging and Cancer, Vol 5, Iss 3, Pp 62-69 (2024)
ABSTRACT Background DNA double‐strand breaks are known to be the most lethal kind of DNA damage as they cause genomic instability. Visualization and quantification of these breaks are possible via staining of the phosphorylated histone H2A variant
Externí odkaz:
https://doaj.org/article/df242f7b3cf6407baf8fc3898067f0cf
Autor:
Felix Y Zhou, David P Waterman, Marissa Ashton, Suhaily Caban-Penix, Gonen Memisoglu, Vinay V Eapen, James E Haber
Publikováno v:
eLife, Vol 13 (2024)
Cells evoke the DNA damage checkpoint (DDC) to inhibit mitosis in the presence of DNA double-strand breaks (DSBs) to allow more time for DNA repair. In budding yeast, a single irreparable DSB is sufficient to activate the DDC and induce cell cycle ar
Externí odkaz:
https://doaj.org/article/e9d05221d44d4a67a23d1c8f1550e0c7
Autor:
Tomoya Suzuki, Ryoya Tetsuka, Atsuya Iwasaki, Tsutomu Shimura, Ryoichi Hirayama, Asako J Nakamura
Publikováno v:
Advances in Redox Research, Vol 13, Iss , Pp 100114- (2024)
In contemporary society, humans are susceptible to various radiation-borne hazards, including exposure to therapeutic modalities using low-linear energy transfer (low-LET) radiations (X-rays and γ-rays), natural high-LET radiation sourced from cosmi
Externí odkaz:
https://doaj.org/article/ca2779aec2444d428c3cf67194b142ea
Publikováno v:
Nucleus, Vol 15, Iss 1 (2024)
DNA double-strand break (DSB) is the most dangerous type of DNA damage, which may lead to cell death or oncogenic mutations. Homologous recombination (HR) and nonhomologous end-joining (NHEJ) are two typical DSB repair mechanisms. Recently, many stud
Externí odkaz:
https://doaj.org/article/7751d5556522435ca788274cdf66af7c
Publikováno v:
Neurobiology of Disease, Vol 201, Iss , Pp 106675- (2024)
α-synuclein (αSyn) is a presynaptic and nuclear protein that aggregates in important neurodegenerative diseases such as Parkinson's Disease (PD), Parkinson's Disease Dementia (PDD) and Lewy Body Dementia (LBD). Our past work suggests that nuclear
Externí odkaz:
https://doaj.org/article/21878170bbf543eb8878f2c707f5951b
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background Inherited variations in DNA double-strand break (DSB) repair pathway are known to influence ovarian cancer occurrence, progression and treatment response. Despite its significance, survival-associated genetic variants within the D
Externí odkaz:
https://doaj.org/article/44b311a2d8f540fdb61b03090e943cce
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Background The repair of peripheral nerve injury poses a clinical challenge, necessitating further investigation into novel therapeutic approaches. In recent years, bone marrow mesenchymal stromal cell (MSC)-derived mitochondrial transfer ha
Externí odkaz:
https://doaj.org/article/0adb62b5cd9c4000b36847779653c98d
Akademický článek
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Publikováno v:
Frontiers in Epigenetics and Epigenomics, Vol 2 (2024)
Histone post-translational modifications and variants play crucial roles in the adaptability of chromatin structure, facilitating rapid responses necessary for biological processes such as transcription, replication, and DNA damage signaling. Notably
Externí odkaz:
https://doaj.org/article/e82cdfecb18a40bd8dd8a5c462e1c11b