Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Double, John"'
Autor:
Puri, Rajiv, Palit, V., Loadman, Paul, Flannigan, G. Michael, Shah, T.K., Choudry, G.A., Basu, Saurajyoti, Double, John A., Lenaz, G., Chawla, S., Beer, M., Kalken, C.V., de Boer, R., Beijnen, J.H., Twelves, Christopher J., Phillips, Roger M.
The quinone based bioreductive drug apaziquone (EO9) failed to demonstrate efficacy in previous phase II studies following intravenous administration. We determined the dose of apaziquone that can be safely administered intravesically and explored it
Externí odkaz:
http://hdl.handle.net/10454/4150
Autor:
Hasan, J., Shnyder, Steven, Clamp, A.R., McGown, A.T., Bicknell, R., Presta, M., Bibby, Michael C., Double, John A., Craig, S., Leeming, D., Stevenson, K., Gallagher, J.T., Jayson, G.C.
Background: In previous experiments, we showed that heparin oligosaccharides inhibit the angiogenic cytokine fibroblast growth factor-2. Here, we present the first in vivo study of size-fractionated heparin oligosaccharides in four models of angiogen
Externí odkaz:
http://hdl.handle.net/10454/3089
Autor:
Gibson, Paul, Gill, Jason H., Khan, Parveen A., Seargent, Jill M., Martin, Sandie W., Batman, Philip A., Griffith, John, Bradley, C., Double, John A., Bibby, Michael C., Loadman, Paul
The cytochrome P450 family of enzymes is involved in the Phase I metabolism of a wide variety of compounds. Although generally involved with detoxification, overexpression of one family member, cytochrome P450 1B1 (CYP1B1), has been associated with h
Externí odkaz:
http://hdl.handle.net/10454/4043
Autor:
Choudry, Guzanfar A., Hamilton Stewart, P.A., Double, John A., Krul, M.R.L., Naylor, Brian, Flannigan, G. Michael, Shah, Tariq K., Phillips, Roger M.
The indolequinone EO9 demonstrated good preclinical activity but failed to show clinical efficacy against a range of tumours following intravenous drug administration. A significant factor in EO9's failure in the clinic has been attributed to its rap
Externí odkaz:
http://hdl.handle.net/10454/3889
Autor:
Akhtar, Saghir *, Hughes, Marcus D., Khan, Alim, Bibby, Mike, Hussain, Majad, Nawaz, Qamar, Double, John, Sayyed, Pakeeza
Publikováno v:
In Advanced Drug Delivery Reviews 2000 44(1):3-21
Publikováno v:
Telomeres & Telomerase; 2002, p209-216, 8p
Autor:
Walker, John M., Double, John A., Thompson, Michael J., Naasani, Imad, Yamori, Takao, Tsuruo, Takashi
Publikováno v:
Telomeres & Telomerase; 2002, p197-207, 11p
Autor:
Walker, John M., Double, John A., Thompson, Michael J., Gourdeau, Henriette, Speevak, Marsha D., Jetté, Lucie, Chevrette, Mario
Publikováno v:
Telomeres & Telomerase; 2002, p173-195, 23p
Publikováno v:
Telomeres & Telomerase; 2002, p165-171, 7p