Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Doty B.A. Ojwach"'
Autor:
Daniel M. Muema, Ngomu A. Akilimali, Okechukwu C. Ndumnego, Sipho S. Rasehlo, Raveshni Durgiah, Doty B.A. Ojwach, Nasreen Ismail, Mary Dong, Amber Moodley, Krista L. Dong, Zaza M. Ndhlovu, Jenniffer M. Mabuka, Bruce D. Walker, Jaclyn K. Mann, Thumbi Ndung’u
Publikováno v:
BMC Medicine, Vol 18, Iss 1, Pp 1-17 (2020)
Abstract Introduction Immunological damage in acute HIV infection (AHI) may predispose to detrimental clinical sequela. However, studies on the earliest HIV-induced immunological changes are limited, particularly in sub-Saharan Africa. We assessed th
Externí odkaz:
https://doaj.org/article/12144ae325134e809d1d43e98283a822
Publikováno v:
Virology
Identification of viral immune escape mutations that compromise HIV’s ability to replicate may aid rational attenuation-based vaccine design. Previously we reported amino acids associated with altered viral replication capacity (RC) from a sequence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::905260513daa3ab42f602eb72109d219
https://hdl.handle.net/21.11116/0000-0007-B03A-1
https://hdl.handle.net/21.11116/0000-0007-B03A-1
Autor:
Okechukwu C. Ndumnego, Doty B.A. Ojwach, Sipho S. Rasehlo, Mary Dong, Nasreen Ismail, Ngomu Akeem Akilimali, Thumbi Ndung'u, Jenniffer M. Mabuka, Raveshni Durgiah, Amber Moodley, Bruce D. Walker, Krista L. Dong, Jaclyn K. Mann, Zaza M. Ndhlovu, Daniel M. Muema
Publikováno v:
BMC Medicine
BMC Medicine, Vol 18, Iss 1, Pp 1-17 (2020)
BMC Medicine, Vol 18, Iss 1, Pp 1-17 (2020)
Introduction Immunological damage in acute HIV infection (AHI) may predispose to detrimental clinical sequela. However, studies on the earliest HIV-induced immunological changes are limited, particularly in sub-Saharan Africa. We assessed the plasma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96caf44ece9c239d0a8890e91c5be99d
http://europepmc.org/articles/PMC7093991
http://europepmc.org/articles/PMC7093991
Autor:
Zabrina L. Brumme, Doty B.A. Ojwach, Mark A. Brockman, Jaclyn K. Mann, Vladimir Novitsky, Daniel MacMillan, Tarylee Reddy, Thumbi Ndung'u
Publikováno v:
Journal of Virology. 93
Volume 92, no. 19, e00811-18, 2018, [https://doi.org/10.1128/JVI.00811-18][1]. Page 15, Acknowledgments, line 15: The following sentence should be added after “KwaZulu-Natal”: “J.K.M. received additional funding from the Poliomyelitis Research
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6024553743efa8d9cd0498b351eb678
https://doi.org/10.1128/jvi.01924-18
https://doi.org/10.1128/jvi.01924-18
Autor:
Zabrina L. Brumme, Vladimir Novitsky, Tarylee Reddy, Mark A. Brockman, Thumbi Ndung'u, Jaclyn K. Mann, Doty B.A. Ojwach, Daniel MacMillan
Publikováno v:
Journal of Virology
CD8(+) T cell-mediated escape mutations in Gag can reduce HIV-1 replication capacity (RC) and alter disease progression, but less is known about immune-mediated attenuation in other HIV-1 proteins. We generated 487 recombinant viruses encoding RT-int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb4517a22da18ae1cbaff9ead9e0a83c
https://europepmc.org/articles/PMC6146804/
https://europepmc.org/articles/PMC6146804/
Autor:
Muema, Daniel M., Ngomu A. Akilimali, Okechukwu C. Ndumnego, Sipho S. Rasehlo, Raveshni Durgiah, Doty B.A. Ojwach, Ismail, Nasreen, Dong, Mary, Moodley, Amber, Dong, Krista L., Ndhlovu, Zaza M., Jenniffer M. Mabuka, Walker, Bruce D., Mann, Jaclyn K., Ndung’u, Thumbi
Additional file 2: Supplementary figure 1. Viral load and CD4+ T cell kinetics in participants for whom cytokines were measured. A. Viral loads kinetics in untreated participants (N = 12). B. Viral load kinetics in ART early-treated participants (N =
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37846dcdbe4c70089ec7b5a3aa2b3b57
Autor:
Muema, Daniel M., Ngomu A. Akilimali, Okechukwu C. Ndumnego, Sipho S. Rasehlo, Raveshni Durgiah, Doty B.A. Ojwach, Ismail, Nasreen, Dong, Mary, Moodley, Amber, Dong, Krista L., Ndhlovu, Zaza M., Jenniffer M. Mabuka, Walker, Bruce D., Mann, Jaclyn K., Ndung’u, Thumbi
Additional file 4: Supplementary figure 3. Set point viral loads are inversely associated with set point CD4+ T cell counts in untreated individuals. A. Correlation between peak viral loads and nadir CD4+ T cell counts. B. Correlation between set poi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::961fafc3cfbb1d0801aad728305bdb37
Autor:
Muema, Daniel M., Ngomu A. Akilimali, Okechukwu C. Ndumnego, Sipho S. Rasehlo, Raveshni Durgiah, Doty B.A. Ojwach, Ismail, Nasreen, Dong, Mary, Moodley, Amber, Dong, Krista L., Ndhlovu, Zaza M., Jenniffer M. Mabuka, Walker, Bruce D., Mann, Jaclyn K., Ndung’u, Thumbi
Additional file 2: Supplementary figure 1. Viral load and CD4+ T cell kinetics in participants for whom cytokines were measured. A. Viral loads kinetics in untreated participants (N = 12). B. Viral load kinetics in ART early-treated participants (N =
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca089c57fe7c4dbe2991b2b0b78c5198
Autor:
Muema, Daniel M., Ngomu A. Akilimali, Okechukwu C. Ndumnego, Sipho S. Rasehlo, Raveshni Durgiah, Doty B.A. Ojwach, Ismail, Nasreen, Dong, Mary, Moodley, Amber, Dong, Krista L., Ndhlovu, Zaza M., Jenniffer M. Mabuka, Walker, Bruce D., Mann, Jaclyn K., Ndung’u, Thumbi
Additional file 3: Supplementary figure 2. Presence of attenuating polymorphisms predicts replication capacity of transmitted/founder viruses. A. Similarity of transmitted/founder viruses to the consensus sequence. B. Phylogenetic tree of the transmi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba5de2e32ad194504e021ddbeee35fc8
Autor:
Muema, Daniel M., Ngomu A. Akilimali, Okechukwu C. Ndumnego, Sipho S. Rasehlo, Raveshni Durgiah, Doty B.A. Ojwach, Ismail, Nasreen, Dong, Mary, Moodley, Amber, Dong, Krista L., Ndhlovu, Zaza M., Jenniffer M. Mabuka, Walker, Bruce D., Mann, Jaclyn K., Ndung’u, Thumbi
Additional file 5: Supplementary figure 4. Hyperacute HIV infection is associated with dysregulation of proportions of blood lymphoid and myeloid cells. A. Monocytes percentages. B. Total lymphocytes percentages. C. Eosinophils percentages. D. Basoph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42332ce2df6c389809280fbd9bdd2b66