Výsledky vyhledávání

Akademický článek

Neural Wiskott-Aldrich syndrome protein modulates Wnt signaling and is required for hair follicle cycling in mice

Autor: Lyubimova, A., Garber, J.J., Upadhyay, G., Sharov, A.A., Anastasoaie, F., Yajnik, V., Cotsarelis, G., Dotto, G.P., Botchkarev, Vladimir A., Snapper, S.B.

The Rho family GTPases Cdc42 and Rac1 are critical regulators of the actin cytoskeleton and are essential for skin and hair function. Wiskott-Aldrich syndrome family proteins act downstream of these GTPases, controlling actin assembly and cytoskeleta

Externí odkaz: http://hdl.handle.net/10454/6073

Zobrazit plný text záznamu

Akademický článek

Bone morphogenetic protein signaling regulates size of hair follicles and modulates the expression of cell cycle-associated genes.

Autor: Sharov, A.A., Sharova, T.Y., Mardaryev, Andrei N., Tommasi di Vignano, A., Atoyan, R., Weiner, L., Yang, Shi, Brissette, J.L., Dotto, G.P., Botchkarev, Vladimir A.

Bone morphogenetic protein (BMP) signaling is involved in the regulation of a large variety of developmental programs, including those controlling organ sizes. Here, we show that transgenic (TG) mice overexpressing the BMP antagonist noggin (promoter

Externí odkaz: http://hdl.handle.net/10454/3789

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

To be or not to be: The second law of thermodynamics and the flow of life and death

Autor: Dotto, G.P.

Publikováno v: EMBO reports, vol. 21, no. 7, pp. e50861

Hamlet's question is the artist's expression of the meaning of life. The second law of thermodynamics is the physicist's equivalent.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1900::30382e82b11cf3166ccb5f1e42dd6066
https://serval.unil.ch/notice/serval:BIB_FA2DAEC7AE2D

Zobrazit plný text záznamu

Conjectures, refutations and the search for truths: Science, symbolic truths and the devil

Autor: Dotto, G.P.

Publikováno v: EMBO reports, vol. 21, no. 2, pp. e49924

In times of fake news, post-truths and post-science, the principles of science can inform all kinds of inquiries into the true nature of reality.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1900::8cf88b371824f5213dd2cfabec03d92a
https://serval.unil.ch/resource/serval:BIB_4D4D3BF285B8.P001/REF.pdf

Zobrazit plný text záznamu

Autophagy Controls CSL/RBPJκ Stability through a p62/SQSTM1-Dependent Mechanism

Autor: Goruppi, S., Jo, S.H., Laszlo, C., Clocchiatti, A., Neel, V., Dotto, G.P.

Publikováno v: Cell Reports, Vol 24, Iss 12, Pp 3108-3114.e4 (2018)
Cell reports
Cell reports, vol. 24, no. 12, pp. 3108-3114.e4

SUMMARY Cancer-associated fibroblasts (CAFs) are important at all tumor stages. CSL/RBPJκ suppresses the gene expression program leading to CAF activation and associated metabolic reprogramming, as well as autophagy. Little is known about CSL protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::493d3eb1ed2b475a83c6c858442350fd
http://www.sciencedirect.com/science/article/pii/S2211124718313147

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Sex Hormones and Anticancer Immunity

Autor: Özdemir, B.C., Dotto, G.P.

Publikováno v: Clinical cancer research, vol. 25, no. 15, pp. 4603-4610

The impact of sex hormones on anticancer immunity deserves attention due to the importance of the immune system in cancer therapy and the recognition of sex differences in immunity. Cancer is ultimately the result of failed immune surveillance, and t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1900::700ba962f5477cb921749cd8613b2c27
https://serval.unil.ch/notice/serval:BIB_2A2BB09AAB25

Zobrazit plný text záznamu

Sexual dimorphism in cancer

Autor: Clocchiatti, A., Cora, E., Zhang, Y., Dotto, G.P.

Publikováno v: Nature Reviews. Cancer, vol. 16, no. 5, pp. 330-339

The incidence of many types of cancer arising in organs with non-reproductive functions is significantly higher in male populations than in female populations, with associated differences in survival. Occupational and/or behavioural factors are well-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1900::f58c1759138660283311b80adbc95a22
https://serval.unil.ch/notice/serval:BIB_393065D9F168

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Vyhledávací nástroje:

Upřesnit hledání