Early-stage lung cancer is driven by a transitional cell state dependent on a KRAS-ITGA3-SRC axis.

Autor: Moye AL; Stem Cell Program and Divisions of Hematology/Oncology and Pulmonary Medicine, Boston Children's Hospital, Boston, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA., Dost AF; Stem Cell Program and Divisions of Hematology/Oncology and Pulmonary Medicine, Boston Children's Hospital, Boston, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Hubrecht Institute, Oncode Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), Utrecht, The Netherlands., Ietswaart R; Department of Genetics, Harvard Medical School, Boston, MA, USA., Sengupta S; Stem Cell Program and Divisions of Hematology/Oncology and Pulmonary Medicine, Boston Children's Hospital, Boston, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA., Ya V; Stem Cell Program and Divisions of Hematology/Oncology and Pulmonary Medicine, Boston Children's Hospital, Boston, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA., Aluya C; Stem Cell Program and Divisions of Hematology/Oncology and Pulmonary Medicine, Boston Children's Hospital, Boston, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA., Fahey CG; Stem Cell Program and Divisions of Hematology/Oncology and Pulmonary Medicine, Boston Children's Hospital, Boston, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Harvard University and Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Louie SM; Stem Cell Program and Divisions of Hematology/Oncology and Pulmonary Medicine, Boston Children's Hospital, Boston, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA., Paschini M; Stem Cell Program and Divisions of Hematology/Oncology and Pulmonary Medicine, Boston Children's Hospital, Boston, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA., Kim CF; Stem Cell Program and Divisions of Hematology/Oncology and Pulmonary Medicine, Boston Children's Hospital, Boston, MA, USA. carla.kim@childrens.harvard.edu.; Harvard Stem Cell Institute, Cambridge, MA, USA. carla.kim@childrens.harvard.edu.; Department of Genetics, Harvard Medical School, Boston, MA, USA. carla.kim@childrens.harvard.edu.

Publikováno v: The EMBO journal [EMBO J] 2024 Jul; Vol. 43 (14), pp. 2843-2861. Date of Electronic Publication: 2024 May 16.

Single-cell and spatial transcriptome characterize coinhibitory cell-cell communications during histological progression of lung adenocarcinoma.

Autor: Judong Luo, Qianman Gao, Meihua Wang, Hui Liu, Hong Zhu

Publikováno v: Frontiers in Immunology; 2024, p1-15, 15p

Targeting the Hippo/YAP/TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers.

Autor: Howard, Alexander¹ (AUTHOR), Bojko, Jodie¹ (AUTHOR), Flynn, Benjamin¹ (AUTHOR), Bowen, Sophie¹ (AUTHOR), Jungwirth, Ute^1,2 (AUTHOR), Walko, Gernot^1,2 (AUTHOR) g.walko@bath.ac.uk

Publikováno v: Experimental Dermatology. Oct2022, Vol. 31 Issue 10, p1477-1499. 23p.

Functional interaction between endothelin-1 and ZEB1/YAP signaling regulates cellular plasticity and metastasis in high-grade serous ovarian cancer.

Autor: Sestito, Rosanna¹ (AUTHOR), Tocci, Piera¹ (AUTHOR), Roman, Celia¹ (AUTHOR), Di Castro, Valeriana¹ (AUTHOR), Bagnato, Anna¹ (AUTHOR) annateresa.bagnato@ifo.it

Publikováno v: Journal of Experimental & Clinical Cancer Research (17569966). 4/28/2022, Vol. 41, p1-15. 15p.

A non-canonical repressor function of JUN restrains YAP activity and liver cancer growth.

Autor: Kurlishchuk Y; Transcriptional Control of Tissue Homeostasis Lab, Leibniz Institute on Aging, Fritz Lipmann Institute e.V., Beutenbergstr. 11, 07745, Jena, Germany., Cindric Vranesic A; Transcriptional Control of Tissue Homeostasis Lab, Leibniz Institute on Aging, Fritz Lipmann Institute e.V., Beutenbergstr. 11, 07745, Jena, Germany., Jessen M; Transcriptional Control of Tissue Homeostasis Lab, Leibniz Institute on Aging, Fritz Lipmann Institute e.V., Beutenbergstr. 11, 07745, Jena, Germany., Kipping A; Transcriptional Control of Tissue Homeostasis Lab, Leibniz Institute on Aging, Fritz Lipmann Institute e.V., Beutenbergstr. 11, 07745, Jena, Germany., Ritter C; Transcriptional Control of Tissue Homeostasis Lab, Leibniz Institute on Aging, Fritz Lipmann Institute e.V., Beutenbergstr. 11, 07745, Jena, Germany., Kim K; Transcriptional Control of Tissue Homeostasis Lab, Leibniz Institute on Aging, Fritz Lipmann Institute e.V., Beutenbergstr. 11, 07745, Jena, Germany., Cramer P; Transcriptional Control of Tissue Homeostasis Lab, Leibniz Institute on Aging, Fritz Lipmann Institute e.V., Beutenbergstr. 11, 07745, Jena, Germany., von Eyss B; Transcriptional Control of Tissue Homeostasis Lab, Leibniz Institute on Aging, Fritz Lipmann Institute e.V., Beutenbergstr. 11, 07745, Jena, Germany. bjoern.voneyss@leibniz-fli.de.

Publikováno v: The EMBO journal [EMBO J] 2024 Oct; Vol. 43 (20), pp. 4578-4603. Date of Electronic Publication: 2024 Aug 29.