Prediction of in vivo developmental toxicity of all-trans-retinoic acid based on in vitro toxicity data and in silico physiologically based kinetic modeling

Autor: Louisse, Jochem, Bosgra, Sieto, Blaauboer, Bas J., Rietjens, Ivonne M. C. M., Verwei, Miriam, LS IRAS Tox CMT/ATX, Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA1

Publikováno v: Archives of Toxicology, 7, 89, 1135-1148
Archives of Toxicology, 89(7), 1135-1148
Archives of Toxicology, 89(7), 1135. Springer Verlag
Archives of Toxicology 89 (2015) 7

The use of laboratory animals for toxicity testing in chemical safety assessment meets increasing ethical, economic and legislative constraints. The development, validation and application of reliable alternatives for in vivo toxicity testing are the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8844d1be7279ffdbbeddeed18998add9
https://dspace.library.uu.nl/handle/1874/327563

Dose-dependent kinetics of inhaled methylethylketone in man

Autor: Juha Liira, Vesa Riihimäki, Gunnar Johanson

Publikováno v: Toxicology letters. 50(2-3)

Physiologically based stimulation of earlier human inhalation exposure to methylethylketone (MEK) at a concentration of 200 ppm for 4 h suggested that the kinetics were dose-dependent. Two male volunteers were therefore exposed to MEK for 4 h at 3 ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c33b272632cdd14be7ca9bbc0d7430
https://pubmed.ncbi.nlm.nih.gov/2309238

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Chloroquine serum concentration and side effects: Evidence for dose-dependent kinetics

Autor: Folke Jansson, Yngve Bergkvist, Laila Hellström, Britta Domeij-Nyberg, Marianne Frisk-Holmberg

Publikováno v: Clinical Pharmacology & Therapeutics. 25:345-350

Serum concentrations of chloroquine were determined fluorometrically in 100 rheumatoid patients who had been treated with 0.25 gm daily for at least 2 mo. The total dose varied between 3.7 and 400 gm. No patient received more than 75 gm annually. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7624956d9fe32b2a8598ad9941dd8800
https://doi.org/10.1002/cpt1979253345

Dose-dependent kinetics of caffeine in rats

Autor: R. Latini, Maurizio Bonati, Silvio Garattini, D. Castelli

Publikováno v: Toxicology Letters. 2:267-270

Caffeine was administered orally to male rats at 3 different doses (1, 10, 100 mg/kg). Plasma and brain concentrations were measured and kinetic parameters calculated. Ratios between doses were much lower than between areas under the curve in plasma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fd56637156bff7efc76d877ffd47fee8
https://doi.org/10.1016/0378-4274(78)90024-3